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Items: 1 to 20 of 54

1.

Gene Editing: Practical Application in the Lab.

Geurts AM, Ekker SC.

Hum Gene Ther. 2016 Jun;27(6):417-8. doi: 10.1089/hum.2016.29029.amg. No abstract available.

PMID:
27322167
2.

p66Shc regulates renal vascular tone in hypertension-induced nephropathy.

Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A.

J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.

PMID:
27270176
3.

The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility.

Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ.

J Biol Chem. 2016 Jul 15;291(29):14939-53. doi: 10.1074/jbc.M116.730481. Epub 2016 May 19.

PMID:
27226619
4.

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.

Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E.

Sci Rep. 2016 Feb 26;6:22154. doi: 10.1038/srep22154.

5.

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease.

Rubattu S, Di Castro S, Schulz H, Geurts AM, Cotugno M, Bianchi F, Maatz H, Hummel O, Falak S, Stanzione R, Marchitti S, Scarpino S, Giusti B, Kura A, Gensini GF, Peyvandi F, Mannucci PM, Rasura M, Sciarretta S, Dwinell MR, Hubner N, Volpe M.

J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701.

6.

Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats.

Kaplan K, Echert AE, Massat B, Puissant MM, Palygin O, Geurts AM, Hodges MR.

J Appl Physiol (1985). 2016 May 1;120(9):1070-81. doi: 10.1152/japplphysiol.01015.2015. Epub 2016 Feb 11.

PMID:
26869713
7.

Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome.

Bennett B, Helbling D, Meng H, Jarzembowski J, Geurts AM, Friederich MW, Van Hove JL, Lawlor MW, Dimmock DP.

Free Radic Biol Med. 2016 Mar;92:141-51. doi: 10.1016/j.freeradbiomed.2016.01.001. Epub 2016 Jan 8.

PMID:
26773591
8.

The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction.

Priestley JR, Kautenburg KE, Casati MC, Endres BT, Geurts AM, Lombard JH.

Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4.

PMID:
26637559
9.

Pappa2 is linked to salt-sensitive hypertension in Dahl S rats.

Cowley AW Jr, Yang C, Kumar V, Lazar J, Jacob H, Geurts AM, Liu P, Dayton A, Kurth T, Liang M.

Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3.

PMID:
26534937
10.

Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells.

Hegan PS, Ostertag E, Geurts AM, Mooseker MS.

Cytoskeleton (Hoboken). 2015 Oct;72(10):503-16. doi: 10.1002/cm.21259. Epub 2015 Oct 23.

PMID:
26446290
11.

Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.

Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA.

Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18.

12.

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta.

Endres BT, Staruschenko A, Schulte M, Geurts AM, Palygin O.

J Vis Exp. 2015 Jun 10;(100):e52734. doi: 10.3791/52734.

13.

Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury.

Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang N, Liang M.

Kidney Int. 2015 Oct;88(4):796-803. doi: 10.1038/ki.2015.176. Epub 2015 Jun 24.

14.

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease.

Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H.

Genetics. 2015 Jun;200(2):423-30. doi: 10.1534/genetics.115.176594. Epub 2015 Mar 27.

15.

Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.

Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL.

Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16.

16.

SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.

Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ.

Circ Cardiovasc Genet. 2015 Apr;8(2):294-304. doi: 10.1161/CIRCGENETICS.114.000527. Epub 2015 Jan 27.

17.

Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.

Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ.

Am J Physiol Regul Integr Comp Physiol. 2015 Mar 1;308(5):R379-90. doi: 10.1152/ajpregu.00256.2014. Epub 2014 Dec 24.

18.

Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats.

Geurts AM, Mattson DL, Liu P, Cabacungan E, Skelton MM, Kurth TM, Yang C, Endres BT, Klotz J, Liang M, Cowley AW Jr.

Hypertension. 2015 Feb;65(2):447-55. doi: 10.1161/HYPERTENSIONAHA.114.04179. Epub 2014 Dec 1.

19.

Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.

Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ.

PLoS One. 2014 Nov 14;9(11):e112878. doi: 10.1371/journal.pone.0112878. eCollection 2014.

20.

CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.

Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ.

Cancer Res. 2014 Nov 15;74(22):6419-29. doi: 10.1158/0008-5472.CAN-13-3212. Epub 2014 Aug 29.

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