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Results: 1 to 20 of 41

1.

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease.

Qin W, Dion SL, Kutny PM, Zhang Y, Cheng A, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H.

Genetics. 2015 Mar 27. pii: genetics.115.176594. [Epub ahead of print]

2.

Mutation of SH2B3 (LNK), a Genome-Wide Association Study Candidate for Hypertension, Attenuates Dahl Salt-Sensitive Hypertension via Inflammatory Modulation.

Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL.

Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16.

PMID:
25776069
3.

SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.

Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ.

Circ Cardiovasc Genet. 2015 Apr;8(2):294-304. doi: 10.1161/CIRCGENETICS.114.000527. Epub 2015 Jan 27.

PMID:
25628389
4.

Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.

Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ.

Am J Physiol Regul Integr Comp Physiol. 2015 Mar 1;308(5):R379-90. doi: 10.1152/ajpregu.00256.2014. Epub 2014 Dec 24.

PMID:
25540098
5.

Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats.

Geurts AM, Mattson DL, Liu P, Cabacungan E, Skelton MM, Kurth TM, Yang C, Endres BT, Klotz J, Liang M, Cowley AW Jr.

Hypertension. 2015 Feb;65(2):447-55. doi: 10.1161/HYPERTENSIONAHA.114.04179. Epub 2014 Dec 1.

PMID:
25452472
6.

Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.

Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ.

PLoS One. 2014 Nov 14;9(11):e112878. doi: 10.1371/journal.pone.0112878. eCollection 2014.

7.

CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.

Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ.

Cancer Res. 2014 Nov 15;74(22):6419-29. doi: 10.1158/0008-5472.CAN-13-3212. Epub 2014 Aug 29.

PMID:
25172839
8.

Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat.

Endres BT, Priestley JR, Palygin O, Flister MJ, Hoffman MJ, Weinberg BD, Grzybowski M, Lombard JH, Staruschenko A, Moreno C, Jacob HJ, Geurts AM.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18.

9.

HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats.

Jin C, Sun J, Stilphen CA, Smith SM, Ocasio H, Bermingham B, Darji S, Guha A, Patel R, Geurts AM, Jacob HJ, Lambert NA, O'Connor PM.

Hypertension. 2014 Sep;64(3):541-50. doi: 10.1161/HYPERTENSIONAHA.114.03549. Epub 2014 Jun 16.

PMID:
24935944
10.

CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney.

Rudemiller N, Lund H, Jacob HJ, Geurts AM, Mattson DL; PhysGen Knockout Program.

Hypertension. 2014 Mar;63(3):559-64. doi: 10.1161/HYPERTENSIONAHA.113.02191. Epub 2013 Dec 16.

11.

Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase.

Beyer AM, Raffai G, Weinberg BD, Fredrich K, Rodgers MS, Geurts AM, Jacob HJ, Dwinell MR, Lombard JH.

Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H339-47. doi: 10.1152/ajpheart.00619.2012. Epub 2013 Dec 6.

12.

Identifying multiple causative genes at a single GWAS locus.

Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C.

Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4.

13.

Gene targeting in NOD mouse embryos using zinc-finger nucleases.

Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM.

Diabetes. 2014 Jan;63(1):68-74. doi: 10.2337/db13-0192. Epub 2013 Aug 23.

14.

Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics.

Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA.

Neuropharmacology. 2014 Jan;76 Pt B:250-8. doi: 10.1016/j.neuropharm.2013.05.047. Epub 2013 Jun 18.

15.

Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains.

Yang S, Takizawa A, Foeckler J, Zappa A, Gjoka M, Schilling R, Hansen C, Xu H, Kalloway S, Grzybowski M, Davis GD, Jacob HJ, Geurts AM.

Stem Cells Dev. 2013 May 1. doi: 10.1089/scd.2012.0416. Epub 2013 May 1. Retraction in: Stem Cells Dev. 2013 Oct 15;22(20):2813.

PMID:
23635087
16.

Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage.

Mattson DL, Lund H, Guo C, Rudemiller N, Geurts AM, Jacob H.

Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15;304(6):R407-14. doi: 10.1152/ajpregu.00304.2012. Epub 2013 Jan 30.

17.

Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury.

Chen CC, Geurts AM, Jacob HJ, Fan F, Roman RJ.

Physiol Genomics. 2013 Feb 4;45(3):110-8. doi: 10.1152/physiolgenomics.00119.2012. Epub 2012 Dec 18.

18.

Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.

Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowksi M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z.

FASEB J. 2013 Mar;27(3):930-41. doi: 10.1096/fj.12-205526. Epub 2012 Nov 29.

19.

Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension.

Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley AW Jr.

Cell Metab. 2012 Feb 8;15(2):201-8. doi: 10.1016/j.cmet.2012.01.003.

20.

Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells.

Wilber A, Ulloa Montoya F, Hammer L, Moriarity BS, Geurts AM, Largaespada DA, Verfaillie CM, McIvor RS, Lakshmipathy U.

Stem Cells Int. 2011;2011:717069. doi: 10.4061/2011/717069. Epub 2011 Oct 2.

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