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Discovery of Innovative Therapies for Rare Immune-Mediated Inflammatory Diseases via Off-Label Prescription of Biologics: The Case of IL-6 Receptor Blockade in Castleman's Disease.

Musters A, Assaf A, Gerlag DM, Tak PP, Tas SW.

Front Immunol. 2015 Dec 11;6:625. doi: 10.3389/fimmu.2015.00625. eCollection 2015. Review.


Serum Vaspin Levels Are Associated with the Development of Clinically Manifest Arthritis in Autoantibody-Positive Individuals.

Maijer KI, Neumann E, Müller-Ladner U, Drop DA, Ramwadhdoebe TH, Choi IY, Gerlag DM, de Hair MJ, Tak PP.

PLoS One. 2015 Dec 15;10(12):e0144932. doi: 10.1371/journal.pone.0144932. eCollection 2015.


Dynamic contrast-enhanced magnetic resonance imaging using pharmacokinetic modeling: Initial experience in early arthritis patients.

Maijer KI, van der Leij C, de Hair MJ, Tas SW, Maas M, Gerlag DM, Tak PP, Lavini C.

Arthritis Rheumatol. 2015 Oct 16. doi: 10.1002/art.39469. [Epub ahead of print]


Does the multi-biomarker disease activity score have diagnostic value in early rheumatoid arthritis and unclassified arthritis?

Maijer KI, Li W, Sasso EH, Gerlag DM, Defranoux NA, Tak PP.

Ann Rheum Dis. 2015 Nov;74(11):2097-9. doi: 10.1136/annrheumdis-2015-207911. Epub 2015 Sep 2. No abstract available.


Prevalence of Anti-Citrullinated Protein Antibodies and IgM Rheumatoid Factor in First-Degree Relatives of Dutch Rheumatoid Arthritis Patients.

Maijer KI, Gerlag DM, Tak PP.

Arthritis Rheumatol. 2015 Dec;67(12):3324-6. doi: 10.1002/art.39412. No abstract available.


Expression of Prostaglandin E2 Enzymes in the Synovium of Arthralgia Patients at Risk of Developing Rheumatoid Arthritis and in Early Arthritis Patients.

de Hair MJ, Leclerc P, Newsum EC, Maijer KI, van de Sande MG, Ramwadhdoebe TH, van Schaardenburg D, van Baarsen LG, Korotkova M, Gerlag DM, Tak PP, Jakobsson PJ.

PLoS One. 2015 Jul 30;10(7):e0133669. doi: 10.1371/journal.pone.0133669. eCollection 2015.


Single-joint Assessment for the Evaluation of Intraarticular Treatment: Responsiveness and Discrimination of the Composite Change Index.

Aalbers CJ, Gerlag DM, Vervoordeldonk MJ, Tak PP, Landewé RB.

J Rheumatol. 2015 Sep;42(9):1672-6. doi: 10.3899/jrheum.140956. Epub 2015 Jul 15.


Nuclear Factor-κB-inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study.

Maijer KI, Noort AR, de Hair MJ, van der Leij C, van Zoest KP, Choi IY, Gerlag DM, Maas M, Tak PP, Tas SW.

J Rheumatol. 2015 Sep;42(9):1573-81. doi: 10.3899/jrheum.150245. Epub 2015 Jul 15.


A clinically based protein discovery strategy to identify potential biomarkers of response to anti-TNF-α treatment of psoriatic arthritis.

Collins ES, Butt AQ, Gibson DS, Dunn MJ, Fearon U, van Kuijk AW, Gerlag DM, Pontifex E, Veale DJ, Tak PP, FitzGerald O, Pennington SR.

Proteomics Clin Appl. 2015 Jun 24. doi: 10.1002/prca.201500051. [Epub ahead of print]


DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis.

Ai R, Whitaker JW, Boyle DL, Tak PP, Gerlag DM, Wang W, Firestein GS.

Arthritis Rheumatol. 2015 Jul;67(7):1978-80. doi: 10.1002/art.39123. No abstract available.


Preclinical inflammatory rheumatic diseases: an overview and relevant nomenclature.

Raza K, Gerlag DM.

Rheum Dis Clin North Am. 2014 Nov;40(4):569-80. doi: 10.1016/j.rdc.2014.07.001. Epub 2014 Sep 2. Review.


Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis.

Ademowo OS, Hernandez B, Collins E, Rooney C, Fearon U, van Kuijk AW, Tak PP, Gerlag DM, FitzGerald O, Pennington SR.

Ann Rheum Dis. 2016 Jan;75(1):234-41. doi: 10.1136/annrheumdis-2014-205417. Epub 2014 Sep 3.


From synovial tissue to peripheral blood: myeloid related protein 8/14 is a sensitive biomarker for effective treatment in early drug development in patients with rheumatoid arthritis.

Choi IY, Gerlag DM, Holzinger D, Roth J, Tak PP.

PLoS One. 2014 Aug 28;9(8):e106253. doi: 10.1371/journal.pone.0106253. eCollection 2014.


Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?

van Baarsen LG, Lebre MC, van der Coelen D, Aarrass S, Tang MW, Ramwadhdoebe TH, Gerlag DM, Tak PP.

Arthritis Res Ther. 2014 Aug 22;16(4):426. doi: 10.1186/s13075-014-0426-z.


Clock gene expression in different synovial cells of patients with rheumatoid arthritis and osteoarthritis.

Becker T, Tohidast-Akrad M, Humpeler S, Gerlag DM, Kiener HP, Zenz P, Steiner G, Ekmekcioglu C.

Acta Histochem. 2014 Sep;116(7):1199-207. doi: 10.1016/j.acthis.2014.07.001. Epub 2014 Aug 7.


Citrullination of epithelial neutrophil-activating peptide 78/CXCL5 results in conversion from a non-monocyte-recruiting chemokine to a monocyte-recruiting chemokine.

Yoshida K, Korchynskyi O, Tak PP, Isozaki T, Ruth JH, Campbell PL, Baeten DL, Gerlag DM, Amin MA, Koch AE.

Arthritis Rheumatol. 2014 Oct;66(10):2716-27. doi: 10.1002/art.38750.


Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis.

Greven DE, Cohen ES, Gerlag DM, Campbell J, Woods J, Davis N, van Nieuwenhuijze A, Lewis A, Heasmen S, McCourt M, Corkill D, Dodd A, Elvin J, Statache G, Wicks IP, Anderson IK, Nash A, Sleeman MA, Tak PP.

Ann Rheum Dis. 2015 Oct;74(10):1924-30. doi: 10.1136/annrheumdis-2014-205234. Epub 2014 Jun 16.


Reply: To PMID 24574210.

de Hair MJ, van de Sande MG, Ramwadhdoebe TH, van der Leij C, Maas M, Hansson M, Klareskog L, Landewé R, Serre G, van Schaardenburg D, Gerlag DM, van Baarsen LG, Tak PP.

Arthritis Rheumatol. 2014 Jun;66(6):1683-4. doi: 10.1002/art.38411. No abstract available.


Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis.

de Hair MJ, van de Sande MG, Ramwadhdoebe TH, Hansson M, Landewé R, van der Leij C, Maas M, Serre G, van Schaardenburg D, Klareskog L, Gerlag DM, van Baarsen LG, Tak PP.

Arthritis Rheumatol. 2014 Mar;66(3):513-22. doi: 10.1002/art.38273.

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