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Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Data Brief. 2016 Feb 22;7:299-310. doi: 10.1016/j.dib.2016.02.036. eCollection 2016 Jun.


Positional proteomics in the era of the human proteome project on the doorstep of precision medicine.

Eckhard U, Marino G, Butler GS, Overall CM.

Biochimie. 2016 Mar;122:110-8. doi: 10.1016/j.biochi.2015.10.018. Epub 2015 Nov 14. Review.


Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Keller UA, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Matrix Biol. 2016 Jan;49:37-60. doi: 10.1016/j.matbio.2015.09.003. Epub 2015 Sep 25.


Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis.

Bellac CL, Dufour A, Krisinger MJ, Loonchanta A, Starr AE, Auf dem Keller U, Lange PF, Goebeler V, Kappelhoff R, Butler GS, Burtnick LD, Conway EM, Roberts CR, Overall CM.

Cell Rep. 2014 Oct 23;9(2):618-32. doi: 10.1016/j.celrep.2014.09.006. Epub 2014 Oct 9.


A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.

Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele RG, Luo H, Granville DJ, Dive V, McManus BM, Overall CM.

Nat Med. 2014 May;20(5):493-502. doi: 10.1038/nm.3508. Epub 2014 Apr 28.


Matrix metalloproteinase processing of signaling molecules to regulate inflammation.

Butler GS, Overall CM.

Periodontol 2000. 2013 Oct;63(1):123-48. doi: 10.1111/prd.12035. Review.


Site specific cleavage mediated by MMPs regulates function of agrin.

Patel TR, Butler G, McFarlane A, Xie I, Overall CM, Stetefeld J.

PLoS One. 2012;7(9):e43669. doi: 10.1371/journal.pone.0043669. Epub 2012 Sep 11.


Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics.

Prudova A, auf dem Keller U, Butler GS, Overall CM.

Mol Cell Proteomics. 2010 May;9(5):894-911. doi: 10.1074/mcp.M000050-MCP201. Epub 2010 Mar 20.


A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products.

auf dem Keller U, Prudova A, Gioia M, Butler GS, Overall CM.

Mol Cell Proteomics. 2010 May;9(5):912-27. doi: 10.1074/mcp.M000032-MCP201. Epub 2010 Mar 20.


Identification of cellular MMP substrates using quantitative proteomics: isotope-coded affinity tags (ICAT) and isobaric tags for relative and absolute quantification (iTRAQ).

Butler GS, Dean RA, Morrison CJ, Overall CM.

Methods Mol Biol. 2010;622:451-70. doi: 10.1007/978-1-60327-299-5_26.


Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting.

Butler GS, Overall CM.

Nat Rev Drug Discov. 2009 Dec;8(12):935-48. doi: 10.1038/nrd2945. Review.


Updated biological roles for matrix metalloproteinases and new "intracellular" substrates revealed by degradomics.

Butler GS, Overall CM.

Biochemistry. 2009 Nov 24;48(46):10830-45. doi: 10.1021/bi901656f. Review.


Matrix metalloproteinase proteomics: substrates, targets, and therapy.

Morrison CJ, Butler GS, Rodríguez D, Overall CM.

Curr Opin Cell Biol. 2009 Oct;21(5):645-53. doi: 10.1016/ Epub 2009 Jul 16. Review.


Membrane protease degradomics: proteomic identification and quantification of cell surface protease substrates.

Butler GS, Dean RA, Smith D, Overall CM.

Methods Mol Biol. 2009;528:159-76. doi: 10.1007/978-1-60327-310-7_12.


Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

Doucet A, Butler GS, Rodríguez D, Prudova A, Overall CM.

Mol Cell Proteomics. 2008 Oct;7(10):1925-51. doi: 10.1074/mcp.R800012-MCP200. Epub 2008 Jul 2. Review.


Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding.

Butler GS, Dean RA, Tam EM, Overall CM.

Mol Cell Biol. 2008 Aug;28(15):4896-914. doi: 10.1128/MCB.01775-07. Epub 2008 May 27.


Protease yoga: extreme flexibility of a matrix metalloproteinase.

Overall CM, Butler GS.

Structure. 2007 Oct;15(10):1159-61. No abstract available.


Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration.

Vergote D, Butler GS, Ooms M, Cox JH, Silva C, Hollenberg MD, Jhamandas JH, Overall CM, Power C.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19182-7. Epub 2006 Dec 5.


Dissecting the role of matrix metalloproteinases (MMP) and integrin alpha(v)beta3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-Type 1-MMP and alpha(v)beta3 are critical.

Nisato RE, Hosseini G, Sirrenberg C, Butler GS, Crabbe T, Docherty AJ, Wiesner M, Murphy G, Overall CM, Goodman SL, Pepper MS.

Cancer Res. 2005 Oct 15;65(20):9377-87.

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