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Results: 1 to 20 of 818


Integrated continuous biomanufacturing: A new paradigm for biopharmaceutical production.

Goudar CT, Titchener-Hooker N, Konstantinov K.

J Biotechnol. 2015 Aug 20. pii: S0168-1656(15)00667-7. doi: 10.1016/j.jbiotec.2015.08.015. [Epub ahead of print] No abstract available.


Best Practices in Alemtuzumab Administration: Practical Recommendations for Infusion in Patients With Multiple Sclerosis.

McEwan L, Caon C, Chieffe C, Mayer L, Saldana-King T, Miller CE.

J Infus Nurs. 2015 Aug 20. [Epub ahead of print]


A breakthrough novel method to resolve the drug and target interference problem in immunogenicity assays.

Zoghbi J, Xu Y, Grabert R, Theobald V, Richards S.

J Immunol Methods. 2015 Aug 6. pii: S0022-1759(15)30030-2. doi: 10.1016/j.jim.2015.08.002. [Epub ahead of print]


Carcinogenicity testing of eliglustat in mice and rats.

Dagher R, Watzinger M, Chevalier G, Thirion-Delalande C, Gervais F, Forster R.

Regul Toxicol Pharmacol. 2015 Jul 30;73(1):401-412. doi: 10.1016/j.yrtph.2015.07.024. [Epub ahead of print]


Reassessing the NTCTCS Staging Systems for Differentiated Thyroid Cancer, Including Age at Diagnosis.

McLeod DS, Jonklaas J, Brierley JD, Ain KB, Cooper DS, Fein HG, Haugen BR, Ladenson PW, Magner J, Ross DS, Skarulis MC, Steward DL, Xing M, Litofsky DR, Maxon HR, Sherman SI.

Thyroid. 2015 Aug 24. [Epub ahead of print]


Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis.

Turner MJ, Pang PT, Chretien N, Havari E, LaMorte MJ, Oliver J, Pande N, Masterjohn E, Carter K, Reczek D, Brondyk W, Roberts BL, Kaplan JM, Siders WM.

J Neuroimmunol. 2015 Aug 15;285:4-12. doi: 10.1016/j.jneuroim.2015.05.018. Epub 2015 May 20.


Development and application of a high-throughput platform for perfusion-based cell culture processes.

Villiger-Oberbek A, Yang Y, Zhou W, Yang J.

J Biotechnol. 2015 Jul 18;212:21-29. doi: 10.1016/j.jbiotec.2015.06.428. [Epub ahead of print]


Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGFβ Activity Within the Marrow Niche.

Smaldone S, Clayton NP, Del Solar M, Pascual-Gonzales G, Cheng SH, Wentworth BM, Schaffler MB, Ramirez F.

J Bone Miner Res. 2015 Jul 18. doi: 10.1002/jbmr.2598. [Epub ahead of print]


Anti-Endosialin Antibody-Drug Conjugate: Potential in Sarcoma and Other Malignancies.

Rouleau C, Gianolio DA, Smale R, Roth SD, Krumbholz R, Harper J, Munroe KJ, Green TL, Horten BC, Schmid SM, Teicher BA.

Mol Cancer Ther. 2015 Jul 16. [Epub ahead of print]


Long-Term Outcomes Following Therapy in Differentiated Thyroid Carcinoma: NTCTCS Registry Analysis 1987-2012.

Carhill AA, Litofsky DR, Ross DS, Jonklaas J, Cooper DS, Brierley JD, Ladenson PW, Ain KB, Fein HG, Haugen BR, Magner J, Skarulis MC, Steward DL, Xing M, Maxon HR, Sherman SI.

J Clin Endocrinol Metab. 2015 Jul 14:JC20151346. [Epub ahead of print]


Utility of capillary microsampling for rat pharmacokinetic studies: Comparison of tail-vein bleed to jugular vein cannula sampling.

Korfmacher W, Luo Y, Ho S, Sun W, Shen L, Wang J, Wu Z, Guo Y, Snow G, O'Shea T.

J Pharmacol Toxicol Methods. 2015 Jul 9;76:7-14. doi: 10.1016/j.vascn.2015.07.001. [Epub ahead of print]


Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial.

Alton EW, Armstrong DK, Ashby D, Bayfield KJ, Bilton D, Bloomfield EV, Boyd AC, Brand J, Buchan R, Calcedo R, Carvelli P, Chan M, Cheng SH, Collie DD, Cunningham S, Davidson HE, Davies G, Davies JC, Davies LA, Dewar MH, Doherty A, Donovan J, Dwyer NS, Elgmati HI, Featherstone RF, Gavino J, Gea-Sorli S, Geddes DM, Gibson JS, Gill DR, Greening AP, Griesenbach U, Hansell DM, Harman K, Higgins TE, Hodges SL, Hyde SC, Hyndman L, Innes JA, Jacob J, Jones N, Keogh BF, Limberis MP, Lloyd-Evans P, Maclean AW, Manvell MC, McCormick D, McGovern M, McLachlan G, Meng C, Montero MA, Milligan H, Moyce LJ, Murray GD, Nicholson AG, Osadolor T, Parra-Leiton J, Porteous DJ, Pringle IA, Punch EK, Pytel KM, Quittner AL, Rivellini G, Saunders CJ, Scheule RK, Sheard S, Simmonds NJ, Smith K, Smith SN, Soussi N, Soussi S, Spearing EJ, Stevenson BJ, Sumner-Jones SG, Turkkila M, Ureta RP, Waller MD, Wasowicz MY, Wilson JM, Wolstenholme-Hogg P; UK Cystic Fibrosis Gene Therapy Consortium.

Lancet Respir Med. 2015 Jul 3. pii: S2213-2600(15)00245-3. doi: 10.1016/S2213-2600(15)00245-3. [Epub ahead of print]


Is Chronic Pain a Disease in Its Own Right? Discussions from a Pre-OMERACT 2014 Workshop on Chronic Pain.

Taylor AM, Phillips K, Taylor JO, Singh JA, Conaghan PG, Choy EH, Tugwell PS, Kaiser U, Strand V, Simon LS, Mease PJ.

J Rheumatol. 2015 Jul 1. pii: jrheum.141328. [Epub ahead of print]


Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations.

Alcalay RN, Levy OA, Waters CC, Fahn S, Ford B, Kuo SH, Mazzoni P, Pauciulo MW, Nichols WC, Gan-Or Z, Rouleau GA, Chung WK, Wolf P, Oliva P, Keutzer J, Marder K, Zhang X.

Brain. 2015 Sep;138(Pt 9):2648-58. doi: 10.1093/brain/awv179. Epub 2015 Jun 27.


CX3CR1 Is Expressed in Differentiated Human Ciliated Airway Cells and Co-Localizes with Respiratory Syncytial Virus on Cilia in a G Protein-Dependent Manner.

Jeong KI, Piepenhagen PA, Kishko M, DiNapoli JM, Groppo RP, Zhang L, Almond J, Kleanthous H, Delagrave S, Parrington M.

PLoS One. 2015 Jun 24;10(6):e0130517. doi: 10.1371/journal.pone.0130517. eCollection 2015.


No evidence for substrate accumulation in Parkinson brains with GBA mutations.

Gegg ME, Sweet L, Wang BH, Shihabuddin LS, Sardi SP, Schapira AH.

Mov Disord. 2015 Jul;30(8):1085-9. doi: 10.1002/mds.26278. Epub 2015 Jun 11.


Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1.

Shen F, Mao L, Zhu W, Lawton MT, Pechan P, Colosi P, Wu Z, Scaria A, Su H.

Gene Ther. 2015 Jun 19. doi: 10.1038/gt.2015.57. [Epub ahead of print]


End-to-end integrated fully continuous production of recombinant monoclonal antibodies.

Godawat R, Konstantinov K, Rohani M, Warikoo V.

J Biotechnol. 2015 Jun 11. pii: S0168-1656(15)30011-0. doi: 10.1016/j.jbiotec.2015.06.393. [Epub ahead of print] No abstract available.


Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis.

Dodge JC, Treleaven CM, Pacheco J, Cooper S, Bao C, Abraham M, Cromwell M, Sardi SP, Chuang WL, Sidman RL, Cheng SH, Shihabuddin LS.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8100-5. doi: 10.1073/pnas.1508767112. Epub 2015 Jun 8.


Successful within-patient dose escalation of olipudase alfa in acid sphingomyelinase deficiency.

Wasserstein MP, Jones SA, Soran H, Diaz GA, Lippa N, Thurberg BL, Culm-Merdek K, Shamiyeh E, Inguilizian H, Cox GF, Puga AC.

Mol Genet Metab. 2015 May 30. pii: S1096-7192(15)30019-6. doi: 10.1016/j.ymgme.2015.05.013. [Epub ahead of print]

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