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Results: 1 to 20 of 89

1.

The 'mitoflash' probe cpYFP does not respond to superoxide.

Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP.

Nature. 2014 Oct 23;514(7523):E12-4. doi: 10.1038/nature13858. No abstract available.

PMID:
25341790
[PubMed - indexed for MEDLINE]
2.

What is an anti-aging treatment?

Gems D.

Exp Gerontol. 2014 Oct;58:14-8. doi: 10.1016/j.exger.2014.07.003. Epub 2014 Jul 11.

PMID:
25017442
[PubMed - in process]
3.

Evolution of sexually dimorphic longevity in humans.

Gems D.

Aging (Albany NY). 2014 Feb;6(2):84-91. Review.

PMID:
24566422
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans.

Riesen M, Feyst I, Rattanavirotkul N, Ezcurra M, Tullet JM, Papatheodorou I, Ziehm M, Au C, Gilliat AF, Hellberg J, Thornton JM, Gems D.

Aging (Albany NY). 2014 Feb;6(2):98-117.

PMID:
24531613
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D.

PLoS Genet. 2014 Feb 6;10(2):e1004109. doi: 10.1371/journal.pgen.1004109. eCollection 2014 Feb.

PMID:
24516399
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Cell-nonautonomous effects of dFOXO/DAF-16 in aging.

Alic N, Tullet JM, Niccoli T, Broughton S, Hoddinott MP, Slack C, Gems D, Partridge L.

Cell Rep. 2014 Feb 27;6(4):608-16. doi: 10.1016/j.celrep.2014.01.015. Epub 2014 Feb 6.

PMID:
24508462
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans.

Estevez AO, Morgan KL, Szewczyk NJ, Gems D, Estevez M.

Neurotoxicology. 2014 Mar;41:28-43. doi: 10.1016/j.neuro.2013.12.012. Epub 2014 Jan 6.

PMID:
24406377
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The mysterious case of the C. elegans gut granule: death fluorescence, anthranilic acid and the kynurenine pathway.

Coburn C, Gems D.

Front Genet. 2013 Aug 7;4:151. doi: 10.3389/fgene.2013.00151. eCollection 2013.

PMID:
23967012
[PubMed]
Free PMC Article
9.

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans.

Coburn C, Allman E, Mahanti P, Benedetto A, Cabreiro F, Pincus Z, Matthijssens F, Araiz C, Mandel A, Vlachos M, Edwards SA, Fischer G, Davidson A, Pryor RE, Stevens A, Slack FJ, Tavernarakis N, Braeckman BP, Schroeder FC, Nehrke K, Gems D.

PLoS Biol. 2013 Jul;11(7):e1001613. doi: 10.1371/journal.pbio.1001613. Epub 2013 Jul 23.

PMID:
23935448
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans.

Cabreiro F, Gems D.

EMBO Mol Med. 2013 Sep;5(9):1300-10. doi: 10.1002/emmm.201100972. Epub 2013 Aug 1. Review.

PMID:
23913848
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D.

Cell. 2013 Mar 28;153(1):228-39. doi: 10.1016/j.cell.2013.02.035.

PMID:
23540700
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Genetics of longevity in model organisms: debates and paradigm shifts.

Gems D, Partridge L.

Annu Rev Physiol. 2013;75:621-44. doi: 10.1146/annurev-physiol-030212-183712. Epub 2012 Nov 26. Review.

PMID:
23190075
[PubMed - indexed for MEDLINE]
13.

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

Gems D, de la Guardia Y.

Antioxid Redox Signal. 2013 Jul 20;19(3):321-9. doi: 10.1089/ars.2012.4840. Epub 2012 Sep 24. Review.

PMID:
22870907
[PubMed - indexed for MEDLINE]
14.

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.

Virk B, Correia G, Dixon DP, Feyst I, Jia J, Oberleitner N, Briggs Z, Hodge E, Edwards R, Ward J, Gems D, Weinkove D.

BMC Biol. 2012 Jul 31;10:67. doi: 10.1186/1741-7007-10-67.

PMID:
22849329
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The second international conference "genetics of aging and longevity".

Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P.

Aging (Albany NY). 2012 May;4(5):305-17. No abstract available.

PMID:
22661237
[PubMed - indexed for MEDLINE]
Free Article
16.

Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans.

Valentini S, Cabreiro F, Ackerman D, Alam MM, Kunze MB, Kay CW, Gems D.

Mech Ageing Dev. 2012 May;133(5):282-90. doi: 10.1016/j.mad.2012.03.003. Epub 2012 Mar 16.

PMID:
22445852
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.

Ackerman D, Gems D.

PLoS Genet. 2012;8(3):e1002498. doi: 10.1371/journal.pgen.1002498. Epub 2012 Mar 1.

PMID:
22396654
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The mystery of C. elegans aging: an emerging role for fat. Distant parallels between C. elegans aging and metabolic syndrome?

Ackerman D, Gems D.

Bioessays. 2012 Jun;34(6):466-71. doi: 10.1002/bies.201100189. Epub 2012 Feb 27. Review.

PMID:
22371137
[PubMed - indexed for MEDLINE]
19.

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D.

Nature. 2011 Sep 21;477(7365):482-5. doi: 10.1038/nature10296.

PMID:
21938067
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage.

Cabreiro F, Ackerman D, Doonan R, Araiz C, Back P, Papp D, Braeckman BP, Gems D.

Free Radic Biol Med. 2011 Oct 15;51(8):1575-82. doi: 10.1016/j.freeradbiomed.2011.07.020. Epub 2011 Jul 31.

PMID:
21839827
[PubMed - indexed for MEDLINE]
Free PMC Article

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