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Physiological and pathophysiological role of nonsense-mediated mRNA decay.

Ottens F, Gehring NH.

Pflugers Arch. 2016 Jun;468(6):1013-28. doi: 10.1007/s00424-016-1826-5. Epub 2016 Apr 30. Review.


A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs.

Gromadzka AM, Steckelberg AL, Singh KK, Hofmann K, Gehring NH.

Nucleic Acids Res. 2016 Mar 18;44(5):2348-61. doi: 10.1093/nar/gkw009. Epub 2016 Jan 14.


HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.

Ajamian L, Abel K, Rao S, Vyboh K, García-de-Gracia F, Soto-Rifo R, Kulozik AE, Gehring NH, Mouland AJ.

Biomolecules. 2015 Oct 20;5(4):2808-39. doi: 10.3390/biom5042808.


Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.

Fatscher T, Boehm V, Gehring NH.

Cell Mol Life Sci. 2015 Dec;72(23):4523-44. doi: 10.1007/s00018-015-2017-9. Epub 2015 Aug 18. Review.


mRNA metabolism and neuronal disease.

Linder B, Fischer U, Gehring NH.

FEBS Lett. 2015 Jun 22;589(14):1598-606. doi: 10.1016/j.febslet.2015.04.052. Epub 2015 May 13. Review.


CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes.

Steckelberg AL, Altmueller J, Dieterich C, Gehring NH.

Nucleic Acids Res. 2015 May 19;43(9):4687-700. doi: 10.1093/nar/gkv320. Epub 2015 Apr 13.


The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis.

Stockklausner C, Klotter AC, Dickemann N, Kuhlee IN, Duffert CM, Kerber C, Gehring NH, Kulozik AE.

Blood. 2015 Feb 12;125(7):1159-69. doi: 10.1182/blood-2014-07-587170. Epub 2014 Dec 23.


3' UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons.

Boehm V, Haberman N, Ottens F, Ule J, Gehring NH.

Cell Rep. 2014 Oct 23;9(2):555-68. doi: 10.1016/j.celrep.2014.09.012. Epub 2014 Oct 9.


The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay.

Fatscher T, Boehm V, Weiche B, Gehring NH.

RNA. 2014 Oct;20(10):1579-92. doi: 10.1261/rna.044933.114. Epub 2014 Aug 21.


NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins.

Burgute BD, Peche VS, Steckelberg AL, Glöckner G, Gaßen B, Gehring NH, Noegel AA.

Nucleic Acids Res. 2014 Mar;42(5):3177-93. doi: 10.1093/nar/gkt1311. Epub 2013 Dec 17.


Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2.

Clerici M, Deniaud A, Boehm V, Gehring NH, Schaffitzel C, Cusack S.

Nucleic Acids Res. 2014 Feb;42(4):2673-86. doi: 10.1093/nar/gkt1197. Epub 2013 Nov 23.


Studying the composition of mRNPs in vitro using splicing-competent cell extracts.

Steckelberg AL, Gehring NH.

Methods. 2014 Feb;65(3):342-9. doi: 10.1016/j.ymeth.2013.08.033. Epub 2013 Sep 8.


Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.

Singh KK, Wachsmuth L, Kulozik AE, Gehring NH.

RNA Biol. 2013 Aug;10(8):1291-8. doi: 10.4161/rna.25827. Epub 2013 Jul 23.


Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356× mutation in synapsin I.

Giannandrea M, Guarnieri FC, Gehring NH, Monzani E, Benfenati F, Kulozik AE, Valtorta F.

PLoS One. 2013 Jun 20;8(6):e67724. doi: 10.1371/journal.pone.0067724. Print 2013.


CWC22 connects pre-mRNA splicing and exon junction complex assembly.

Steckelberg AL, Boehm V, Gromadzka AM, Gehring NH.

Cell Rep. 2012 Sep 27;2(3):454-61. doi: 10.1016/j.celrep.2012.08.017. Epub 2012 Sep 6.


Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon.

Neu-Yilik G, Amthor B, Gehring NH, Bahri S, Paidassi H, Hentze MW, Kulozik AE.

RNA. 2011 May;17(5):843-54. doi: 10.1261/rna.2401811. Epub 2011 Mar 9.


Assembly, disassembly and recycling: the dynamics of exon junction complexes.

Bono F, Gehring NH.

RNA Biol. 2011 Jan-Feb;8(1):24-9. Epub 2011 Jan 1. Review.


Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII.

Dang Y, Low WK, Xu J, Gehring NH, Dietz HC, Romo D, Liu JO.

J Biol Chem. 2009 Aug 28;284(35):23613-21. doi: 10.1074/jbc.M109.009985. Epub 2009 Jul 1.


Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.

Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S.

EMBO J. 2009 Aug 5;28(15):2293-306. doi: 10.1038/emboj.2009.175. Epub 2009 Jun 25.


The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.

Gehring NH, Lamprinaki S, Hentze MW, Kulozik AE.

PLoS Biol. 2009 May 26;7(5):e1000120. doi: 10.1371/journal.pbio.1000120. Epub 2009 May 26.

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