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Results: 1 to 20 of 29

1.

A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability.

De León H, Boué S, Schlage WK, Boukharov N, Westra JW, Gebel S, VanHooser A, Talikka M, Fields RB, Veljkovic E, Peck MJ, Mathis C, Hoang V, Poussin C, Deehan R, Stolle K, Hoeng J, Peitsch MC.

J Transl Med. 2014 Jun 26;12:185. doi: 10.1186/1479-5876-12-185.

PMID:
24965703
[PubMed - in process]
Free Article
2.

A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.

Kogel U, Schlage WK, Martin F, Xiang Y, Ansari S, Leroy P, Vanscheeuwijck P, Gebel S, Buettner A, Wyss C, Esposito M, Hoeng J, Peitsch MC.

Food Chem Toxicol. 2014 Jun;68:204-17. doi: 10.1016/j.fct.2014.02.034. Epub 2014 Mar 12.

PMID:
24632068
[PubMed - in process]
Free Article
3.

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™).

Xiang Y, Kogel U, Gebel S, Peck MJ, Peitsch MC, Akmaev VR, Hoeng J.

Gene Regul Syst Bio. 2014 Feb 19;8:45-61. doi: 10.4137/GRSB.S13140. eCollection 2014.

PMID:
24596455
[PubMed]
Free PMC Article
4.

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models.

Thomson TM, Sewer A, Martin F, Belcastro V, Frushour BP, Gebel S, Park J, Schlage WK, Talikka M, Vasilyev DM, Westra JW, Hoeng J, Peitsch MC.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):863-78. doi: 10.1016/j.taap.2013.07.007. Epub 2013 Aug 8.

PMID:
23933166
[PubMed - indexed for MEDLINE]
Free Article
5.

Systematic verification of upstream regulators of a computable cellular proliferation network model on non-diseased lung cells using a dedicated dataset.

Belcastro V, Poussin C, Gebel S, Mathis C, Schlage WK, Lichtner RB, Quadt-Humme S, Wagner S, Hoeng J, Peitsch MC.

Bioinform Biol Insights. 2013 Jul 23;7:217-30. doi: 10.4137/BBI.S12167. Print 2013.

PMID:
23926424
[PubMed]
Free PMC Article
6.

A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue.

Westra JW, Schlage WK, Hengstermann A, Gebel S, Mathis C, Thomson T, Wong B, Hoang V, Veljkovic E, Peck M, Lichtner RB, Weisensee D, Talikka M, Deehan R, Hoeng J, Peitsch MC.

Bioinform Biol Insights. 2013 Jun 20;7:167-92. doi: 10.4137/BBI.S11509. Print 2013.

PMID:
23843693
[PubMed]
Free PMC Article
7.

Construction of a computable network model for DNA damage, autophagy, cell death, and senescence.

Gebel S, Lichtner RB, Frushour B, Schlage WK, Hoang V, Talikka M, Hengstermann A, Mathis C, Veljkovic E, Peck M, Peitsch MC, Deehan R, Hoeng J, Westra JW.

Bioinform Biol Insights. 2013;7:97-117. doi: 10.4137/BBI.S11154. Epub 2013 Mar 7.

PMID:
23515068
[PubMed]
Free PMC Article
8.

Towards the validation of a lung tumorigenesis model with mainstream cigarette smoke inhalation using the A/J mouse.

Stinn W, Berges A, Meurrens K, Buettner A, Gebel S, Lichtner RB, Janssens K, Veljkovic E, Xiang Y, Roemer E, Haussmann HJ.

Toxicology. 2013 Mar 8;305:49-64. doi: 10.1016/j.tox.2013.01.005. Epub 2013 Jan 24.

PMID:
23357402
[PubMed - indexed for MEDLINE]
Free Article
9.

Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers.

Mathis C, Poussin C, Weisensee D, Gebel S, Hengstermann A, Sewer A, Belcastro V, Xiang Y, Ansari S, Wagner S, Hoeng J, Peitsch MC.

Am J Physiol Lung Cell Mol Physiol. 2013 Apr 1;304(7):L489-503. doi: 10.1152/ajplung.00181.2012. Epub 2013 Jan 25.

PMID:
23355383
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Lung inflammatory effects, tumorigenesis, and emphysema development in a long-term inhalation study with cigarette mainstream smoke in mice.

Stinn W, Buettner A, Weiler H, Friedrichs B, Luetjen S, van Overveld F, Meurrens K, Janssens K, Gebel S, Stabbert R, Haussmann HJ.

Toxicol Sci. 2013 Feb;131(2):596-611. doi: 10.1093/toxsci/kfs312. Epub 2012 Oct 26.

PMID:
23104432
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue.

Schlage WK, Westra JW, Gebel S, Catlett NL, Mathis C, Frushour BP, Hengstermann A, Van Hooser A, Poussin C, Wong B, Lietz M, Park J, Drubin D, Veljkovic E, Peitsch MC, Hoeng J, Deehan R.

BMC Syst Biol. 2011 Oct 19;5:168. doi: 10.1186/1752-0509-5-168.

PMID:
22011616
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Construction of a computable cell proliferation network focused on non-diseased lung cells.

Westra JW, Schlage WK, Frushour BP, Gebel S, Catlett NL, Han W, Eddy SF, Hengstermann A, Matthews AL, Mathis C, Lichtner RB, Poussin C, Talikka M, Veljkovic E, Van Hooser AA, Wong B, Maria MJ, Peitsch MC, Deehan R, Hoeng J.

BMC Syst Biol. 2011 Jul 2;5:105. doi: 10.1186/1752-0509-5-105.

PMID:
21722388
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes.

Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schüller J, Xu H, Taguchi K, Yamamoto M, Müller T.

Toxicol Sci. 2010 May;115(1):238-52. doi: 10.1093/toxsci/kfq039. Epub 2010 Feb 4.

PMID:
20133372
[PubMed - indexed for MEDLINE]
Free Article
14.

The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression.

Gebel S, Gerstmayer B, Kuhl P, Borlak J, Meurrens K, Müller T.

Toxicol Sci. 2006 Oct;93(2):422-31. Epub 2006 Jul 26.

PMID:
16870687
[PubMed - indexed for MEDLINE]
Free Article
15.

Characterization of Nrf2 activation and heme oxygenase-1 expression in NIH3T3 cells exposed to aqueous extracts of cigarette smoke.

Knörr-Wittmann C, Hengstermann A, Gebel S, Alam J, Müller T.

Free Radic Biol Med. 2005 Dec 1;39(11):1438-48. Epub 2005 Aug 19.

PMID:
16274879
[PubMed - indexed for MEDLINE]
16.

Gene expression profiling in respiratory tissues from rats exposed to mainstream cigarette smoke.

Gebel S, Gerstmayer B, Bosio A, Haussmann HJ, Van Miert E, Müller T.

Carcinogenesis. 2004 Feb;25(2):169-78. Epub 2003 Oct 24.

PMID:
14578158
[PubMed - indexed for MEDLINE]
Free Article
17.

Identification of RELMgamma, a novel resistin-like molecule with a distinct expression pattern.

Gerstmayer B, Küsters D, Gebel S, Müller T, Van Miert E, Hofmann K, Bosio A.

Genomics. 2003 Jun;81(6):588-95.

PMID:
12782128
[PubMed - indexed for MEDLINE]
18.

Kinetics of gene expression profiling in Swiss 3T3 cells exposed to aqueous extracts of cigarette smoke.

Bosio A, Knörr C, Janssen U, Gebel S, Haussmann HJ, Müller T.

Carcinogenesis. 2002 May;23(5):741-8.

PMID:
12016146
[PubMed - indexed for MEDLINE]
Free Article
19.

Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity.

Vanscheeuwijck PM, Teredesai A, Terpstra PM, Verbeeck J, Kuhl P, Gerstenberg B, Gebel S, Carmines EL.

Food Chem Toxicol. 2002 Jan;40(1):113-31. Review.

PMID:
11731041
[PubMed - indexed for MEDLINE]
20.

The activity of NF-kappaB in Swiss 3T3 cells exposed to aqueous extracts of cigarette smoke is dependent on thioredoxin.

Gebel S, Müller T.

Toxicol Sci. 2001 Jan;59(1):75-81.

PMID:
11134546
[PubMed - indexed for MEDLINE]
Free Article

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