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A systems biology approach reveals the dose- and time-dependent effect of primary human airway epithelium tissue culture after exposure to cigarette smoke in vitro.

Mathis C, Gebel S, Poussin C, Belcastro V, Sewer A, Weisensee D, Hengstermann A, Ansari S, Wagner S, Peitsch MC, Hoeng J.

Bioinform Biol Insights. 2015 Mar 9;9:19-35. doi: 10.4137/BBI.S19908. eCollection 2015.


A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability.

De León H, Boué S, Schlage WK, Boukharov N, Westra JW, Gebel S, VanHooser A, Talikka M, Fields RB, Veljkovic E, Peck MJ, Mathis C, Hoang V, Poussin C, Deehan R, Stolle K, Hoeng J, Peitsch MC.

J Transl Med. 2014 Jun 26;12:185. doi: 10.1186/1479-5876-12-185.


A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.

Kogel U, Schlage WK, Martin F, Xiang Y, Ansari S, Leroy P, Vanscheeuwijck P, Gebel S, Buettner A, Wyss C, Esposito M, Hoeng J, Peitsch MC.

Food Chem Toxicol. 2014 Jun;68:204-17. doi: 10.1016/j.fct.2014.02.034. Epub 2014 Mar 12.


Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™).

Xiang Y, Kogel U, Gebel S, Peck MJ, Peitsch MC, Akmaev VR, Hoeng J.

Gene Regul Syst Bio. 2014 Feb 19;8:45-61. doi: 10.4137/GRSB.S13140. eCollection 2014.


Quantitative assessment of biological impact using transcriptomic data and mechanistic network models.

Thomson TM, Sewer A, Martin F, Belcastro V, Frushour BP, Gebel S, Park J, Schlage WK, Talikka M, Vasilyev DM, Westra JW, Hoeng J, Peitsch MC.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):863-78. doi: 10.1016/j.taap.2013.07.007. Epub 2013 Aug 8.


Systematic verification of upstream regulators of a computable cellular proliferation network model on non-diseased lung cells using a dedicated dataset.

Belcastro V, Poussin C, Gebel S, Mathis C, Schlage WK, Lichtner RB, Quadt-Humme S, Wagner S, Hoeng J, Peitsch MC.

Bioinform Biol Insights. 2013 Jul 23;7:217-30. doi: 10.4137/BBI.S12167. Print 2013.


A modular cell-type focused inflammatory process network model for non-diseased pulmonary tissue.

Westra JW, Schlage WK, Hengstermann A, Gebel S, Mathis C, Thomson T, Wong B, Hoang V, Veljkovic E, Peck M, Lichtner RB, Weisensee D, Talikka M, Deehan R, Hoeng J, Peitsch MC.

Bioinform Biol Insights. 2013 Jun 20;7:167-92. doi: 10.4137/BBI.S11509. Print 2013.


Construction of a computable network model for DNA damage, autophagy, cell death, and senescence.

Gebel S, Lichtner RB, Frushour B, Schlage WK, Hoang V, Talikka M, Hengstermann A, Mathis C, Veljkovic E, Peck M, Peitsch MC, Deehan R, Hoeng J, Westra JW.

Bioinform Biol Insights. 2013;7:97-117. doi: 10.4137/BBI.S11154. Epub 2013 Mar 7.


Towards the validation of a lung tumorigenesis model with mainstream cigarette smoke inhalation using the A/J mouse.

Stinn W, Berges A, Meurrens K, Buettner A, Gebel S, Lichtner RB, Janssens K, Veljkovic E, Xiang Y, Roemer E, Haussmann HJ.

Toxicology. 2013 Mar 8;305:49-64. doi: 10.1016/j.tox.2013.01.005. Epub 2013 Jan 24.


Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers.

Mathis C, Poussin C, Weisensee D, Gebel S, Hengstermann A, Sewer A, Belcastro V, Xiang Y, Ansari S, Wagner S, Hoeng J, Peitsch MC.

Am J Physiol Lung Cell Mol Physiol. 2013 Apr 1;304(7):L489-503. doi: 10.1152/ajplung.00181.2012. Epub 2013 Jan 25.


Lung inflammatory effects, tumorigenesis, and emphysema development in a long-term inhalation study with cigarette mainstream smoke in mice.

Stinn W, Buettner A, Weiler H, Friedrichs B, Luetjen S, van Overveld F, Meurrens K, Janssens K, Gebel S, Stabbert R, Haussmann HJ.

Toxicol Sci. 2013 Feb;131(2):596-611. doi: 10.1093/toxsci/kfs312. Epub 2012 Oct 26.


A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue.

Schlage WK, Westra JW, Gebel S, Catlett NL, Mathis C, Frushour BP, Hengstermann A, Van Hooser A, Poussin C, Wong B, Lietz M, Park J, Drubin D, Veljkovic E, Peitsch MC, Hoeng J, Deehan R.

BMC Syst Biol. 2011 Oct 19;5:168. doi: 10.1186/1752-0509-5-168.


Construction of a computable cell proliferation network focused on non-diseased lung cells.

Westra JW, Schlage WK, Frushour BP, Gebel S, Catlett NL, Han W, Eddy SF, Hengstermann A, Matthews AL, Mathis C, Lichtner RB, Poussin C, Talikka M, Veljkovic E, Van Hooser AA, Wong B, Maria MJ, Peitsch MC, Deehan R, Hoeng J.

BMC Syst Biol. 2011 Jul 2;5:105. doi: 10.1186/1752-0509-5-105.


The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes.

Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schüller J, Xu H, Taguchi K, Yamamoto M, Müller T.

Toxicol Sci. 2010 May;115(1):238-52. doi: 10.1093/toxsci/kfq039. Epub 2010 Feb 4.


The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression.

Gebel S, Gerstmayer B, Kuhl P, Borlak J, Meurrens K, Müller T.

Toxicol Sci. 2006 Oct;93(2):422-31. Epub 2006 Jul 26.


Characterization of Nrf2 activation and heme oxygenase-1 expression in NIH3T3 cells exposed to aqueous extracts of cigarette smoke.

Knörr-Wittmann C, Hengstermann A, Gebel S, Alam J, Müller T.

Free Radic Biol Med. 2005 Dec 1;39(11):1438-48. Epub 2005 Aug 19.


Gene expression profiling in respiratory tissues from rats exposed to mainstream cigarette smoke.

Gebel S, Gerstmayer B, Bosio A, Haussmann HJ, Van Miert E, Müller T.

Carcinogenesis. 2004 Feb;25(2):169-78. Epub 2003 Oct 24.


Identification of RELMgamma, a novel resistin-like molecule with a distinct expression pattern.

Gerstmayer B, Küsters D, Gebel S, Müller T, Van Miert E, Hofmann K, Bosio A.

Genomics. 2003 Jun;81(6):588-95.


Kinetics of gene expression profiling in Swiss 3T3 cells exposed to aqueous extracts of cigarette smoke.

Bosio A, Knörr C, Janssen U, Gebel S, Haussmann HJ, Müller T.

Carcinogenesis. 2002 May;23(5):741-8.


Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity.

Vanscheeuwijck PM, Teredesai A, Terpstra PM, Verbeeck J, Kuhl P, Gerstenberg B, Gebel S, Carmines EL.

Food Chem Toxicol. 2002 Jan;40(1):113-31. Review.

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