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Items: 1 to 20 of 217

1.

Selection of individuals for genetic testing for familial hypercholesterolaemia: development and external validation of a prediction model for the presence of a mutation causing familial hypercholesterolaemia.

Besseling J, Reitsma JB, Gaudet D, Brisson D, Kastelein JJ, Hovingh GK, Hutten BA.

Eur Heart J. 2016 Apr 3. pii: ehw135. [Epub ahead of print]

PMID:
27044878
2.

Cohort Profile: The Saguenay Youth Study (SYS).

Pausova Z, Paus T, Abrahamowicz M, Bernard M, Gaudet D, Leonard G, Peron M, Pike GB, Richer L, Séguin JR, Veillette S.

Int J Epidemiol. 2016 Mar 27. pii: dyw023. [Epub ahead of print]

PMID:
27018016
3.

Epigenetic and genetic variations at the TNNT1 gene locus are associated with HDL-C levels and coronary artery disease.

Guay SP, Légaré C, Brisson D, Mathieu P, Bossé Y, Gaudet D, Bouchard L.

Epigenomics. 2016 Mar;8(3):359-71. doi: 10.2217/epi.15.120. Epub 2016 Mar 7.

PMID:
26950807
4.

Novel therapies for severe dyslipidemia originating from human genetics.

Gaudet D.

Curr Opin Lipidol. 2016 Apr;27(2):112-24. doi: 10.1097/MOL.0000000000000281.

PMID:
26849851
5.

Association between a polymorphic poly-T repeat sequence in the promoter of the somatostatin gene and hypertension.

Tremblay M, Brisson D, Gaudet D.

Hypertens Res. 2016 Jan 28. doi: 10.1038/hr.2016.4. [Epub ahead of print]

PMID:
26818653
6.

Gene-based therapies in lipidology: current status and future challenges.

Gaudet D, Brisson D.

Curr Opin Lipidol. 2015 Dec;26(6):553-65. doi: 10.1097/MOL.0000000000000240.

PMID:
26780008
7.

Efficacy and safety of rosuvastatin therapy in children and adolescents with familial hypercholesterolemia: Results from the CHARON study.

Braamskamp MJ, Langslet G, McCrindle BW, Cassiman D, Francis GA, Gagné C, Gaudet D, Morrison KM, Wiegman A, Turner T, Kusters DM, Miller E, Raichlen JS, Wissmar J, Martin PD, Stein EA, Kastelein JJ.

J Clin Lipidol. 2015 Nov-Dec;9(6):741-50. doi: 10.1016/j.jacl.2015.07.011. Epub 2015 Aug 1.

PMID:
26687694
8.

Dietary Vitamin A and Visceral Adiposity: A Modulating Role of the Retinol-Binding Protein 4 Gene.

Goodwin K, Abrahamowicz M, Leonard G, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z.

J Nutrigenet Nutrigenomics. 2015;8(4-6):164-73. doi: 10.1159/000442090. Epub 2015 Dec 15.

PMID:
26667887
9.

Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality.

Villeneuve S, Brisson D, Gaudet D.

J Lipids. 2015;2015:742408. doi: 10.1155/2015/742408. Epub 2015 Oct 28.

10.

LRP1B, BRD2 and CACNA1D: new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.

Houde AA, Ruchat SM, Allard C, Baillargeon JP, St-Pierre J, Perron P, Gaudet D, Brisson D, Hivert MF, Bouchard L.

Epigenomics. 2015 Oct;7(7):1111-22. doi: 10.2217/epi.15.72. Epub 2015 Nov 20.

PMID:
26586120
11.

Issues Affecting Quality of Life and Disease Burden in Lipoprotein Lipase Deficiency (Lpld) - First Step Towards a Pro Measure in Lpld.

Johnson C, Stroes ES, Soran H, Wierzbicki A, Moulin P, Bruckert E, Steinhagen-Thiessen E, Gaudet D, Iotti G, Rastelletti I, Ossenkoppele B, Dippel M, Leclerc M, Averna M.

Value Health. 2015 Nov;18(7):A707. doi: 10.1016/j.jval.2015.09.2658. Epub 2015 Oct 20. No abstract available.

PMID:
26533960
12.

Hospitalizations In Hyperchylomicronemia Patients In Quebec, Canada; Results From A Real-World Observational Study.

Lachaine J, Gaudet D, Miron A, Tremblay K.

Value Health. 2015 Nov;18(7):A679. doi: 10.1016/j.jval.2015.09.2018. Epub 2015 Oct 20. No abstract available.

PMID:
26533807
13.

Visceral fat enhances blood pressure reactivity to physical but not mental challenges in male adolescents.

Van Woudenberg M, Abrahamowicz M, Leonard G, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z.

Pediatr Obes. 2015 Oct;10(5):395-402. doi: 10.1111/ijpo.12068.

PMID:
26364941
14.

Development of a real-time immuno-PCR assay for the quantification of 17β-estradiol in water.

Gaudet D, Nilsson D, Lohr T, Sheedy C.

J Environ Sci Health B. 2015;50(10):683-90. doi: 10.1080/03601234.2015.1048097.

PMID:
26273752
15.

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia.

Gaudet D, Alexander VJ, Baker BF, Brisson D, Tremblay K, Singleton W, Geary RS, Hughes SG, Viney NJ, Graham MJ, Crooke RM, Witztum JL, Brunzell JD, Kastelein JJ.

N Engl J Med. 2015 Jul 30;373(5):438-47. doi: 10.1056/NEJMoa1400283.

16.

Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals.

Shin J, Bourdon C, Bernard M, Wilson MD, Reischl E, Waldenberger M, Ruggeri B, Schumann G, Desrivieres S, Leemans A; IMAGEN Consortium; SYS Consortium, Abrahamowicz M, Leonard G, Richer L, Bouchard L, Gaudet D, Paus T, Pausova Z.

Hum Mol Genet. 2015 Oct 15;24(20):5733-45. doi: 10.1093/hmg/ddv294. Epub 2015 Jul 28.

PMID:
26220975
17.

Alirocumab as Add-On to Atorvastatin Versus Other Lipid Treatment Strategies: ODYSSEY OPTIONS I Randomized Trial.

Bays H, Gaudet D, Weiss R, Ruiz JL, Watts GF, Gouni-Berthold I, Robinson J, Zhao J, Hanotin C, Donahue S.

J Clin Endocrinol Metab. 2015 Aug;100(8):3140-8. doi: 10.1210/jc.2015-1520. Epub 2015 Jun 1.

18.

The effect of an apolipoprotein A-I-containing high-density lipoprotein-mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia: The Modifying Orphan Disease Evaluation (MODE) study.

Hovingh GK, Smits LP, Stefanutti C, Soran H, Kwok S, de Graaf J, Gaudet D, Keyserling CH, Klepp H, Frick J, Paolini JF, Dasseux JL, Kastelein JJ, Stroes ES.

Am Heart J. 2015 May;169(5):736-742.e1. doi: 10.1016/j.ahj.2015.01.008. Epub 2015 Jan 28.

PMID:
25965722
19.

Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals.

El-Bikai R, Tahir MR, Tremblay J, Joffres M, Šeda O, Šedová L, Awadalla P, Laberge C, Knoppers BM, Dumas P, Gaudet D, Ste-Marie LG, Hamet P.

J Hypertens. 2015 Apr;33(4):727-35; discussion 735. doi: 10.1097/HJH.0000000000000475.

PMID:
25915877
20.

The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - a post-hoc analysis of a Phase 3, single-arm, open-label trial.

Stefanutti C, Blom DJ, Averna MR, Meagher EA, Theron Hd, Marais AD, Hegele RA, Sirtori CR, Shah PK, Gaudet D, Vigna GB, Sachais BS, Di Giacomo S, du Plessis AM, Bloedon LT, Balser J, Rader DJ, Cuchel M; Phase 3 HoFH Lomitapide Study Investigators.

Atherosclerosis. 2015 Jun;240(2):408-14. doi: 10.1016/j.atherosclerosis.2015.03.014. Epub 2015 Mar 14.

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