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Results: 1 to 20 of 41

1.

Engineering proteins by reconstructing evolutionary adaptive paths.

Cox VE, Gaucher EA.

Methods Mol Biol. 2014;1179:353-63. doi: 10.1007/978-1-4939-1053-3_24.

PMID:
25055790
[PubMed - in process]
2.

Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids.

Cicerchi C, Li N, Kratzer J, Garcia G, Roncal-Jimenez CA, Tanabe K, Hunter B, Rivard CJ, Sautin YY, Gaucher EA, Johnson RJ, Lanaspa MA.

FASEB J. 2014 Aug;28(8):3339-50. doi: 10.1096/fj.13-243634. Epub 2014 Apr 22.

PMID:
24755741
[PubMed - in process]
3.

Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins.

Risso VA, Gavira JA, Gaucher EA, Sanchez-Ruiz JM.

Proteins. 2014 Jun;82(6):887-96. doi: 10.1002/prot.24575. Epub 2014 Apr 18.

PMID:
24710963
[PubMed - in process]
4.

STRAD pseudokinases regulate axogenesis and LKB1 stability.

Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP.

Neural Dev. 2014 Mar 4;9:5. doi: 10.1186/1749-8104-9-5.

PMID:
24594058
[PubMed - in process]
Free PMC Article
5.

Evolutionary history and metabolic insights of ancient mammalian uricases.

Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher EA.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3763-8. doi: 10.1073/pnas.1320393111. Epub 2014 Feb 18.

PMID:
24550457
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Conservation of protein structure over four billion years.

Ingles-Prieto A, Ibarra-Molero B, Delgado-Delgado A, Perez-Jimenez R, Fernandez JM, Gaucher EA, Sanchez-Ruiz JM, Gavira JA.

Structure. 2013 Sep 3;21(9):1690-7. doi: 10.1016/j.str.2013.06.020. Epub 2013 Aug 8.

PMID:
23932589
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Experimental evolution of protein-protein interaction networks.

Kaçar B, Gaucher EA.

Biochem J. 2013 Aug 1;453(3):311-9. doi: 10.1042/BJ20130205. Review.

PMID:
23849056
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Secondary structure and domain architecture of the 23S and 5S rRNAs.

Petrov AS, Bernier CR, Hershkovits E, Xue Y, Waterbury CC, Hsiao C, Stepanov VG, Gaucher EA, Grover MA, Harvey SC, Hud NV, Wartell RM, Fox GE, Williams LD.

Nucleic Acids Res. 2013 Aug;41(15):7522-35. doi: 10.1093/nar/gkt513. Epub 2013 Jun 14.

PMID:
23771137
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Reconstructing evolutionary adaptive paths for protein engineering.

Cole MF, Cox VE, Gratton KL, Gaucher EA.

Methods Mol Biol. 2013;978:115-25. doi: 10.1007/978-1-62703-293-3_8.

PMID:
23423892
[PubMed - indexed for MEDLINE]
10.

Hyperstability and substrate promiscuity in laboratory resurrections of Precambrian β-lactamases.

Risso VA, Gavira JA, Mejia-Carmona DF, Gaucher EA, Sanchez-Ruiz JM.

J Am Chem Soc. 2013 Feb 27;135(8):2899-902. doi: 10.1021/ja311630a. Epub 2013 Feb 14. Erratum in: J Am Chem Soc. 2013 Jul 17;135(28):10580.

PMID:
23394108
[PubMed - indexed for MEDLINE]
11.

Interchanging functionality among homologous elongation factors using signatures of heterotachy.

Cacan E, Kratzer JT, Cole MF, Gaucher EA.

J Mol Evol. 2013 Feb;76(1-2):4-12. doi: 10.1007/s00239-013-9540-9. Epub 2013 Jan 31.

PMID:
23370546
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Hydrophobic environment is a key factor for the stability of thermophilic proteins.

Gromiha MM, Pathak MC, Saraboji K, Ortlund EA, Gaucher EA.

Proteins. 2013 Apr;81(4):715-21. doi: 10.1002/prot.24232. Epub 2013 Jan 15.

PMID:
23319168
[PubMed - indexed for MEDLINE]
13.

Reconstitution of translation from Thermus thermophilus reveals a minimal set of components sufficient for protein synthesis at high temperatures and functional conservation of modern and ancient translation components.

Zhou Y, Asahara H, Gaucher EA, Chong S.

Nucleic Acids Res. 2012 Sep;40(16):7932-45. doi: 10.1093/nar/gks568. Epub 2012 Jun 20.

PMID:
22723376
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations.

Johnson RJ, Lanaspa MA, Gaucher EA.

Semin Nephrol. 2011 Sep;31(5):394-9. doi: 10.1016/j.semnephrol.2011.08.002.

PMID:
22000645
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The evolutionary history of the catenin gene family during metazoan evolution.

Zhao ZM, Reynolds AB, Gaucher EA.

BMC Evol Biol. 2011 Jul 8;11:198. doi: 10.1186/1471-2148-11-198.

PMID:
21740572
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Utilizing natural diversity to evolve protein function: applications towards thermostability.

Cole MF, Gaucher EA.

Curr Opin Chem Biol. 2011 Jun;15(3):399-406. doi: 10.1016/j.cbpa.2011.03.005. Epub 2011 Apr 4. Review.

PMID:
21470898
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Single-molecule paleoenzymology probes the chemistry of resurrected enzymes.

Perez-Jimenez R, Inglés-Prieto A, Zhao ZM, Sanchez-Romero I, Alegre-Cebollada J, Kosuri P, Garcia-Manyes S, Kappock TJ, Tanokura M, Holmgren A, Sanchez-Ruiz JM, Gaucher EA, Fernandez JM.

Nat Struct Mol Biol. 2011 May;18(5):592-6. doi: 10.1038/nsmb.2020. Epub 2011 Apr 3.

PMID:
21460845
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The molecular evolution of the p120-catenin subfamily and its functional associations.

Carnahan RH, Rokas A, Gaucher EA, Reynolds AB.

PLoS One. 2010 Dec 31;5(12):e15747. doi: 10.1371/journal.pone.0015747.

PMID:
21209830
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Exploiting models of molecular evolution to efficiently direct protein engineering.

Cole MF, Gaucher EA.

J Mol Evol. 2011 Feb;72(2):193-203. doi: 10.1007/s00239-010-9415-2. Epub 2010 Dec 4.

PMID:
21132281
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Deep phylogeny--how a tree can help characterize early life on Earth.

Gaucher EA, Kratzer JT, Randall RN.

Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a002238. doi: 10.1101/cshperspect.a002238. Review.

PMID:
20182607
[PubMed - indexed for MEDLINE]
Free PMC Article

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