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Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch.

MacLeod DT, Choi NM, Briney B, Garces F, Ver LS, Landais E, Murrell B, Wrin T, Kilembe W, Liang CH, Ramos A, Bian CB, Wickramasinghe L, Kong L, Eren K, Wu CY, Wong CH; IAVI Protocol C Investigators & The IAVI African HIV Research Network, Kosakovsky Pond SL, Wilson IA, Burton DR, Poignard P.

Immunity. 2016 May 17;44(5):1215-26. doi: 10.1016/j.immuni.2016.04.016.


Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.

Kong L, Ju B, Chen Y, He L, Ren L, Liu J, Hong K, Su B, Wang Z, Ozorowski G, Ji X, Hua Y, Chen Y, Deller MC, Hao Y, Feng Y, Garces F, Wilson R, Dai K, O'Dell S, McKee K, Mascola JR, Ward AB, Wyatt RT, Li Y, Wilson IA, Zhu J, Shao Y.

Immunity. 2016 Apr 19;44(4):939-50. doi: 10.1016/j.immuni.2016.03.006. Epub 2016 Apr 5.


Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

Garces F, Lee JH, de Val N, de la Pena AT, Kong L, Puchades C, Hua Y, Stanfield RL, Burton DR, Moore JP, Sanders RW, Ward AB, Wilson IA.

Immunity. 2015 Dec 15;43(6):1053-63. doi: 10.1016/j.immuni.2015.11.007.


Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.

Kong L, Torrents de la Peña A, Deller MC, Garces F, Sliepen K, Hua Y, Stanfield RL, Sanders RW, Wilson IA.

Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2099-108. doi: 10.1107/S1399004715013917. Epub 2015 Sep 26.


Correction for Doores et al., Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope.

Doores KJ, Kong L, Krumm SA, Le KM, Sok D, Laserson U, Garces F, Poignard P, Wilson IA, Burton DR.

J Virol. 2015 Jun;89(12):6525. doi: 10.1128/JVI.00593-15. No abstract available.


Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope.

Doores KJ, Kong L, Krumm SA, Le KM, Sok D, Laserson U, Garces F, Poignard P, Wilson IA, Burton DR.

J Virol. 2015 Jan 15;89(2):1105-18. doi: 10.1128/JVI.02905-14. Epub 2014 Nov 5. Erratum in: J Virol. 2015 Jun;89(12):6525.


Structural evolution of glycan recognition by a family of potent HIV antibodies.

Garces F, Sok D, Kong L, McBride R, Kim HJ, Saye-Francisco KF, Julien JP, Hua Y, Cupo A, Moore JP, Paulson JC, Ward AB, Burton DR, Wilson IA.

Cell. 2014 Sep 25;159(1):69-79. doi: 10.1016/j.cell.2014.09.009.


Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.

Peña-Soler E, Fernandez FJ, López-Estepa M, Garces F, Richardson AJ, Quintana JF, Rudd KE, Coll M, Vega MC.

PLoS One. 2014 Jul 11;9(7):e102139. doi: 10.1371/journal.pone.0102139. eCollection 2014.


Current-voltage characteristics in macroporous silicon/SiOx/SnO2:F heterojunctions.

Garcés FA, Urteaga R, Acquaroli LN, Koropecki RR, Arce RD.

Nanoscale Res Lett. 2012 Jul 25;7(1):419. doi: 10.1186/1556-276X-7-419.


The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.

Garces F, Pearl LH, Oliver AW.

Mol Cell. 2011 Nov 4;44(3):385-96. doi: 10.1016/j.molcel.2011.08.036.


The UlaG protein family defines novel structural and functional motifs grafted on an ancient RNase fold.

Fernandez FJ, Garces F, López-Estepa M, Aguilar J, Baldomà L, Coll M, Badia J, Vega MC.

BMC Evol Biol. 2011 Sep 26;11:273. doi: 10.1186/1471-2148-11-273.


Molecular architecture of the Mn2+-dependent lactonase UlaG reveals an RNase-like metallo-beta-lactamase fold and a novel quaternary structure.

Garces F, Fernández FJ, Montellà C, Penya-Soler E, Prohens R, Aguilar J, Baldomà L, Coll M, Badia J, Vega MC.

J Mol Biol. 2010 May 21;398(5):715-29. doi: 10.1016/j.jmb.2010.03.041. Epub 2010 Mar 30.


High plasma phospholipase A2 activity, inflammation markers, and LDL alterations in obesity with or without type 2 diabetes.

Garces F, López F, Niño C, Fernandez A, Chacin L, Hurt-Camejo E, Camejo G, Apitz-Castro R.

Obesity (Silver Spring). 2010 Oct;18(10):2023-9. doi: 10.1038/oby.2010.9. Epub 2010 Feb 4.


A bicistronic lentiviral vector based on the 1D/2A sequence of foot-and-mouth disease virus expresses proteins stoichiometrically.

Torres V, Barra L, Garcés F, Ordenes K, Leal-Ortiz S, Garner CC, Fernandez F, Zamorano P.

J Biotechnol. 2010 Apr 1;146(3):138-42. doi: 10.1016/j.jbiotec.2010.01.017. Epub 2010 Feb 2.


Quaternary structural transitions in the DeoR-type repressor UlaR control transcriptional readout from the L-ascorbate utilization regulon in Escherichia coli.

Garces F, Fernández FJ, Gómez AM, Pérez-Luque R, Campos E, Prohens R, Aguilar J, Baldomà L, Coll M, Badía J, Vega MC.

Biochemistry. 2008 Nov 4;47(44):11424-33. doi: 10.1021/bi800748x. Epub 2008 Oct 10.


The yiaKLX1X2PQRS and ulaABCDEFG gene systems are required for the aerobic utilization of L-ascorbate in Klebsiella pneumoniae strain 13882 with L-ascorbate-6-phosphate as the inducer.

Campos E, de la Riva L, Garces F, Giménez R, Aguilar J, Baldoma L, Badia J.

J Bacteriol. 2008 Oct;190(20):6615-24. doi: 10.1128/JB.00815-08. Epub 2008 Aug 15.


Overproduction, crystallization and preliminary X-ray analysis of the putative L-ascorbate-6-phosphate lactonase UlaG from Escherichia coli.

Garces F, Fernández FJ, Pérez-Luque R, Aguilar J, Baldomà L, Coll M, Badía J, Vega MC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jan 1;64(Pt 1):36-8. Epub 2007 Dec 20.


Aerobic L-ascorbate metabolism and associated oxidative stress in Escherichia coli.

Campos E, Montella C, Garces F, Baldoma L, Aguilar J, Badia J.

Microbiology. 2007 Oct;153(Pt 10):3399-408.


[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy].

Fernández FA, Pintor E, Quesada R, Garcés FJ.

Actas Dermosifiliogr. 2007 Sep;98(7):483-5. Spanish.

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