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Results: 18

1.

The non-synonymous polymorphism at position 114 of the WRN protein affects cholesterol efflux in vitro and correlates with cholesterol levels in vivo.

Bérubé J, Garand C, Lettre G, Lebel M.

Exp Gerontol. 2013 Jun;48(6):533-8. doi: 10.1016/j.exger.2013.03.003. Epub 2013 Mar 21.

PMID:
23523974
[PubMed - indexed for MEDLINE]
2.

Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.

Dallaire A, Garand C, Paquel ER, Mitchell SJ, de Cabo R, Simard MJ, Lebel M.

Aging (Albany NY). 2012 Sep;4(9):636-47.

PMID:
23075628
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activity.

Labbé A, Lafleur VN, Patten DA, Robitaille GA, Garand C, Lamalice L, Lebel M, Richard DE.

Exp Cell Res. 2012 Aug 15;318(14):1620-32. doi: 10.1016/j.yexcr.2012.04.010. Epub 2012 May 31.

PMID:
22659133
[PubMed - indexed for MEDLINE]
4.

NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines.

Tsofack SP, Garand C, Sereduk C, Chow D, Aziz M, Guay D, Yin HH, Lebel M.

Mol Cancer. 2011 Nov 25;10:145. doi: 10.1186/1476-4598-10-145.

PMID:
22118625
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

An integrative approach to identify YB-1-interacting proteins required for cisplatin resistance in MCF7 and MDA-MB-231 breast cancer cells.

Garand C, Guay D, Sereduk C, Chow D, Tsofack SP, Langlois M, Perreault E, Yin HH, Lebel M.

Cancer Sci. 2011 Jul;102(7):1410-7. doi: 10.1111/j.1349-7006.2011.01948.x. Epub 2011 May 5.

PMID:
21466612
[PubMed - indexed for MEDLINE]
6.

Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples.

Lachapelle S, Gagné JP, Garand C, Desbiens M, Coulombe Y, Bohr VA, Hendzel MJ, Masson JY, Poirier GG, Lebel M.

J Proteome Res. 2011 Mar 4;10(3):1216-27. doi: 10.1021/pr100990s. Epub 2011 Feb 16.

PMID:
21210717
[PubMed - indexed for MEDLINE]
7.

Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome.

Labbé A, Garand C, Cogger VC, Paquet ER, Desbiens M, Le Couteur DG, Lebel M.

J Gerontol A Biol Sci Med Sci. 2011 Mar;66(3):264-78. doi: 10.1093/gerona/glq184. Epub 2010 Oct 25.

PMID:
20974729
[PubMed - indexed for MEDLINE]
8.

Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin.

Lebel M, Massip L, Garand C, Thorin E.

Ann N Y Acad Sci. 2010 Jun;1197:40-4. doi: 10.1111/j.1749-6632.2010.05189.x. Review.

PMID:
20536831
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide.

Labbé A, Turaga RV, Paquet ER, Garand C, Lebel M.

BMC Genomics. 2010 Feb 22;11:127. doi: 10.1186/1471-2164-11-127.

PMID:
20175907
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms.

Massip L, Garand C, Labbé A, Perreault E, Turaga RV, Bohr VA, Lebel M.

Oncogene. 2010 Mar 11;29(10):1486-97. doi: 10.1038/onc.2009.443. Epub 2009 Dec 7.

PMID:
19966859
[PubMed - indexed for MEDLINE]
11.

Vitamin C restores healthy aging in a mouse model for Werner syndrome.

Massip L, Garand C, Paquet ER, Cogger VC, O'Reilly JN, Tworek L, Hatherell A, Taylor CG, Thorin E, Zahradka P, Le Couteur DG, Lebel M.

FASEB J. 2010 Jan;24(1):158-72. doi: 10.1096/fj.09-137133. Epub 2009 Sep 9.

PMID:
19741171
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses.

Turaga RV, Paquet ER, Sild M, Vignard J, Garand C, Johnson FB, Masson JY, Lebel M.

Cell Cycle. 2009 Jul 1;8(13):2080-92. Epub 2009 Jul 5.

PMID:
19502800
[PubMed - indexed for MEDLINE]
Free Article
13.

Cytological Analysis of Defense-Related Mechanisms Induced in Pea Root Tissues in Response to Colonization by Nonpathogenic Fusarium oxysporum Fo47.

Benhamou N, Garand C.

Phytopathology. 2001 Aug;91(8):730-40. doi: 10.1094/PHYTO.2001.91.8.730.

PMID:
18944029
[PubMed]
Free Article
14.

The strand separation and nuclease activities associated with YB-1 are dispensable for cisplatin resistance but overexpression of YB-1 in MCF7 and MDA-MB-231 breast tumor cells generates several chemoresistance signatures.

Guay D, Evoy AA, Paquet E, Garand C, Bachvarova M, Bachvarov D, Lebel M.

Int J Biochem Cell Biol. 2008;40(11):2492-507. doi: 10.1016/j.biocel.2008.04.011. Epub 2008 May 15.

PMID:
18571458
[PubMed - indexed for MEDLINE]
15.

The human endonuclease III enzyme is a relevant target to potentiate cisplatin cytotoxicity in Y-box-binding protein-1 overexpressing tumor cells.

Guay D, Garand C, Reddy S, Schmutte C, Lebel M.

Cancer Sci. 2008 Apr;99(4):762-9. doi: 10.1111/j.1349-7006.2008.00739.x. Epub 2008 Feb 27.

PMID:
18307537
[PubMed - indexed for MEDLINE]
16.

Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue.

Massip L, Garand C, Turaga RV, Deschênes F, Thorin E, Lebel M.

Exp Gerontol. 2006 Feb;41(2):157-68. Epub 2005 Dec 5.

PMID:
16330174
[PubMed - indexed for MEDLINE]
17.

In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.

Deschênes F, Massip L, Garand C, Lebel M.

Hum Mol Genet. 2005 Nov 1;14(21):3293-308. Epub 2005 Sep 29.

PMID:
16195394
[PubMed - indexed for MEDLINE]
Free Article
18.

Ability of nonpathogenic Fusarium oxysporum strain Fo47 to induce resistance against Pythium ultimum infection in cucumber.

Benhamou N, Garand C, Goulet A.

Appl Environ Microbiol. 2002 Aug;68(8):4044-60.

PMID:
12147506
[PubMed - indexed for MEDLINE]
Free PMC Article

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