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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1858 1
1881 1
1895 1
1898 2
1904 1
1906 1
1907 2
1908 1
1910 1
1912 2
1913 2
1914 1
1915 1
1916 1
1918 1
1920 1
1921 1
1922 1
1925 1
1926 2
1927 1
1928 3
1929 1
1930 4
1932 7
1933 5
1935 4
1936 4
1937 2
1938 2
1940 1
1941 2
1942 3
1943 3
1945 2
1946 23
1947 18
1948 33
1949 21
1950 27
1951 47
1952 44
1953 58
1954 48
1955 52
1956 54
1957 59
1958 50
1959 62
1960 60
1961 63
1962 87
1963 119
1964 175
1965 141
1966 141
1967 179
1968 242
1969 230
1970 263
1971 358
1972 367
1973 419
1974 481
1975 672
1976 766
1977 684
1978 882
1979 923
1980 1000
1981 1087
1982 1222
1983 1471
1984 1632
1985 1823
1986 1999
1987 2246
1988 2521
1989 2879
1990 3309
1991 3753
1992 4563
1993 5262
1994 6050
1995 6678
1996 6951
1997 7693
1998 7881
1999 8368
2000 9162
2001 9596
2002 9968
2003 9618
2004 9934
2005 10079
2006 10580
2007 10361
2008 10736
2009 11063
2010 11327
2011 11739
2012 12130
2013 12229
2014 12769
2015 13061
2016 13215
2017 13705
2018 13473
2019 14007
2020 15907
2021 17784
2022 18293
2023 18146
2024 7939

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Search Results

362,116 results

Results by year

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Page 1
Fusion-positive skin/adnexal carcinomas.
Agaimy A. Agaimy A. Genes Chromosomes Cancer. 2022 May;61(5):274-284. doi: 10.1002/gcc.23031. Epub 2022 Mar 7. Genes Chromosomes Cancer. 2022. PMID: 35167714 Review.
In the last two decades, several skin adnexal entities driven by specific fusions have been described; some of them represent new entities (eg, secretory carcinoma harboring NTRK fusions), while others are old established entities with newly discovered underlying ge …
In the last two decades, several skin adnexal entities driven by specific fusions have been described; some of them represent new ent …
Identifying patients with NTRK fusion cancer.
Solomon JP, Benayed R, Hechtman JF, Ladanyi M. Solomon JP, et al. Ann Oncol. 2019 Nov 1;30(Suppl_8):viii16-viii22. doi: 10.1093/annonc/mdz384. Ann Oncol. 2019. PMID: 31738428 Free PMC article. Review.
Due to the efficacy of tropomyosin receptor kinase (TRK) inhibitor therapy and the recent Food and Drug Administration approval of larotrectinib, it is now clinically important to accurately and efficiently identify patients with neurotrophic TRK (NTRK) fusion-driven cance …
Due to the efficacy of tropomyosin receptor kinase (TRK) inhibitor therapy and the recent Food and Drug Administration approval of larotrect …
Fusion Genes and RNAs in Cancer Development.
Taniue K, Akimitsu N. Taniue K, et al. Noncoding RNA. 2021 Feb 4;7(1):10. doi: 10.3390/ncrna7010010. Noncoding RNA. 2021. PMID: 33557176 Free PMC article. Review.
In addition, some fusion RNAs have been shown to function as noncoding RNAs and to affect cancer progression. Fusion genes and RNAs will therefore become increasingly important as diagnostic and therapeutic targets for cancer development. ...
In addition, some fusion RNAs have been shown to function as noncoding RNAs and to affect cancer progression. Fusion genes and …
Fusion Genes Altered in Adult Malignant Gliomas.
You G, Fan X, Hu H, Jiang T, Chen CC. You G, et al. Front Neurol. 2021 Oct 4;12:715206. doi: 10.3389/fneur.2021.715206. eCollection 2021. Front Neurol. 2021. PMID: 34671307 Free PMC article. Review.
By now, studies on gene fusions in gliomas remain limited. However, some current clinical trials targeting fusion genes have presented exciting preliminary findings. The aim of this review is to summarize all the reported fusion genes in high-grade gliomas so …
By now, studies on gene fusions in gliomas remain limited. However, some current clinical trials targeting fusion genes have p …
Recent advances in cancer fusion transcript detection.
Dorney R, Dhungel BP, Rasko JEJ, Hebbard L, Schmitz U. Dorney R, et al. Brief Bioinform. 2023 Jan 19;24(1):bbac519. doi: 10.1093/bib/bbac519. Brief Bioinform. 2023. PMID: 36527429 Free PMC article. Review.
To date, most studies have neglected chromosomal rearrangement-independent fusion transcripts and complex fusion structures such as double or triple-hop fusions, and fusion-circRNAs. In this review, we untangle fusion-related terminology and pro …
To date, most studies have neglected chromosomal rearrangement-independent fusion transcripts and complex fusion structures su …
Fusion-associated carcinomas of the breast: Diagnostic, prognostic, and therapeutic significance.
Loo SK, Yates ME, Yang S, Oesterreich S, Lee AV, Wang XS. Loo SK, et al. Genes Chromosomes Cancer. 2022 May;61(5):261-273. doi: 10.1002/gcc.23029. Epub 2022 Feb 17. Genes Chromosomes Cancer. 2022. PMID: 35106856 Free PMC article. Review.
Examples of the most significant recurrent gene fusions to date include (1) ESR1::CCDC170 gene fusions in luminal B and endocrine-resistant breast cancer that exert oncogenic function via modulating the HER2/HER3/SRC Proto-Oncogene (SRC) complex, (2) ESR1 exon 6 …
Examples of the most significant recurrent gene fusions to date include (1) ESR1::CCDC170 gene fusions in luminal B and endocr …
Programmed cell fusion in development and homeostasis.
Iosilevskii Y, Podbilewicz B. Iosilevskii Y, et al. Curr Top Dev Biol. 2021;144:215-244. doi: 10.1016/bs.ctdb.2020.12.013. Epub 2021 Jan 29. Curr Top Dev Biol. 2021. PMID: 33992154 Review.
During post-embryonic development, plasma membrane fusions continue to shape complex neuron structures and organs such as the vulva, while during adulthood fusion participates in cell and tissue repair. These processes rely on two fusion proteins (fusogens): …
During post-embryonic development, plasma membrane fusions continue to shape complex neuron structures and organs such as the vulva, …
NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls.
Solomon JP, Linkov I, Rosado A, Mullaney K, Rosen EY, Frosina D, Jungbluth AA, Zehir A, Benayed R, Drilon A, Hyman DM, Ladanyi M, Sireci AN, Hechtman JF. Solomon JP, et al. Mod Pathol. 2020 Jan;33(1):38-46. doi: 10.1038/s41379-019-0324-7. Epub 2019 Aug 2. Mod Pathol. 2020. PMID: 31375766 Free PMC article.
Here, we investigate the performance of immunohistochemistry and DNA-based next-generation sequencing to indirectly or directly detect NTRK fusions relative to an RNA-based next-generation sequencing approach in the largest cohort of NTRK fusion positive solid tumor …
Here, we investigate the performance of immunohistochemistry and DNA-based next-generation sequencing to indirectly or directly detect NTRK …
Identifying patients with NTRK fusion cancer.
Solomon JP, Benayed R, Hechtman JF, Ladanyi M. Solomon JP, et al. Ann Oncol. 2019 Nov;30 Suppl 8:viii16-viii22. doi: 10.1093/annonc/mdz384. Epub 2019 Dec 24. Ann Oncol. 2019. PMID: 32223934 Review.
Due to the efficacy of tropomyosin receptor kinase (TRK) inhibitor therapy and the recent Food and Drug Administration approval of larotrectinib, it is now clinically important to accurately and efficiently identify patients with neurotrophic TRK (NTRK) fusion-driven cance …
Due to the efficacy of tropomyosin receptor kinase (TRK) inhibitor therapy and the recent Food and Drug Administration approval of larotrect …
Diagnosis and management of TRK fusion cancer.
Kummar S, Italiano A, Brose MS, Carlson JJ, Sullivan SD, Lassen U, Federman N. Kummar S, et al. Am J Manag Care. 2022 Jan;28(2 Suppl):S15-S25. doi: 10.37765/ajmc.2022.88834. Am J Manag Care. 2022. PMID: 35201680 Free PMC article. Review.
The tropomyosin receptor kinase (TRK) family of proteins is encoded by neurotrophic tyrosine receptor kinase (NTRK) genes and has a role in the development and normal functioning of the nervous system. NTRK gene fusions have been identified as oncogenic drivers in a wide r …
The tropomyosin receptor kinase (TRK) family of proteins is encoded by neurotrophic tyrosine receptor kinase (NTRK) genes and has a role in …
362,116 results
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