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Results: 1 to 20 of 162

1.

In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy.

Huda SS, Forrest R, Paterson N, Jordan F, Sattar N, Freeman DJ.

Hypertension. 2014 May;63(5):1094-101. doi: 10.1161/HYPERTENSIONAHA.113.01824. Epub 2014 Mar 3.

PMID:
24591340
[PubMed - indexed for MEDLINE]
2.

Co-occurrence of anaerobic bacteria in colorectal carcinomas.

Warren RL, Freeman DJ, Pleasance S, Watson P, Moore RA, Cochrane K, Allen-Vercoe E, Holt RA.

Microbiome. 2013 May 15;1(1):16. doi: 10.1186/2049-2618-1-16.

PMID:
24450771
[PubMed]
Free PMC Article
3.

A phase 2 randomized trial of paclitaxel and carboplatin with or without panitumumab for first-line treatment of advanced non-small-cell lung cancer.

Crawford J, Swanson P, Schwarzenberger P, Sandler A, Prager D, Zhang K, Freeman DJ, Johnson CW, Krishnan K, Johnson D.

J Thorac Oncol. 2013 Dec;8(12):1510-8. doi: 10.1097/JTO.0b013e3182a7d1da.

PMID:
24389433
[PubMed - in process]
4.

Gene expression profiles can predict panitumumab monotherapy responsiveness in human tumor xenograft models.

Boedigheimer MJ, Freeman DJ, Kiaei P, Damore MA, Radinsky R.

Neoplasia. 2013 Feb;15(2):125-32.

PMID:
23441127
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester.

Meyer BJ, Stewart FM, Brown EA, Cooney J, Nilsson S, Olivecrona G, Ramsay JE, Griffin BA, Caslake MJ, Freeman DJ.

J Clin Endocrinol Metab. 2013 Feb;98(2):643-52. doi: 10.1210/jc.2012-3481. Epub 2013 Jan 21.

PMID:
23337718
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies.

Hodson L, Neville M, Chong MF, Rogers I, Huda SS, Freeman DJ, Frayn KN, Fielding BA.

Nutr Metab Cardiovasc Dis. 2013 Nov;23(11):1128-33. doi: 10.1016/j.numecd.2012.11.003. Epub 2012 Dec 8.

PMID:
23228218
[PubMed - indexed for MEDLINE]
7.

Derivation of HLA types from shotgun sequence datasets.

Warren RL, Choe G, Freeman DJ, Castellarin M, Munro S, Moore R, Holt RA.

Genome Med. 2012 Dec 10;4(12):95. doi: 10.1186/gm396. eCollection 2012.

PMID:
23228053
[PubMed]
Free PMC Article
8.

Endothelial FOS expression and pre-eclampsia.

Mackenzie RM, Sandrim VC, Carty DM, McClure JD, Freeman DJ, Dominiczak AF, McBride MW, Delles C.

BJOG. 2012 Dec;119(13):1564-71. doi: 10.1111/1471-0528.12016. Epub 2012 Nov 2.

PMID:
23121125
[PubMed - indexed for MEDLINE]
9.

Preeclampsia is associated with compromised maternal synthesis of long-chain polyunsaturated fatty acids, leading to offspring deficiency.

Mackay VA, Huda SS, Stewart FM, Tham K, McKenna LA, Martin I, Jordan F, Brown EA, Hodson L, Greer IA, Meyer BJ, Freeman DJ.

Hypertension. 2012 Oct;60(4):1078-85. doi: 10.1161/HYPERTENSIONAHA.112.197897. Epub 2012 Sep 4.

PMID:
22949531
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.

Norman MH, Andrews KL, Bo YY, Booker SK, Caenepeel S, Cee VJ, D'Angelo ND, Freeman DJ, Herberich BJ, Hong FT, Jackson CL, Jiang J, Lanman BA, Liu L, McCarter JD, Mullady EL, Nishimura N, Pettus LH, Reed AB, Miguel TS, Smith AL, Stec MM, Tadesse S, Tasker A, Aidasani D, Zhu X, Subramanian R, Tamayo NA, Wang L, Whittington DA, Wu B, Wu T, Wurz RP, Yang K, Zalameda L, Zhang N, Hughes PE.

J Med Chem. 2012 Sep 13;55(17):7796-816. doi: 10.1021/jm300846z. Epub 2012 Aug 30. Erratum in: J Med Chem. 2012 Oct 25;55(20):8975.

PMID:
22897589
[PubMed - indexed for MEDLINE]
11.

Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.

Wurz RP, Liu L, Yang K, Nishimura N, Bo Y, Pettus LH, Caenepeel S, Freeman DJ, McCarter JD, Mullady EL, Miguel TS, Wang L, Zhang N, Andrews KL, Whittington DA, Jiang J, Subramanian R, Hughes PE, Norman MH.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5714-20. doi: 10.1016/j.bmcl.2012.06.078. Epub 2012 Jul 3.

PMID:
22832322
[PubMed - indexed for MEDLINE]
12.

Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer.

Freeman DJ, McDorman K, Ogbagabriel S, Kozlosky C, Yang BB, Doshi S, Perez-Ruxio JJ, Fanslow W, Starnes C, Radinsky R.

Mol Cancer. 2012 Jul 25;11:47. doi: 10.1186/1476-4598-11-47.

PMID:
22830443
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.

Smith AL, D'Angelo ND, Bo YY, Booker SK, Cee VJ, Herberich B, Hong FT, Jackson CL, Lanman BA, Liu L, Nishimura N, Pettus LH, Reed AB, Tadesse S, Tamayo NA, Wurz RP, Yang K, Andrews KL, Whittington DA, McCarter JD, Miguel TS, Zalameda L, Jiang J, Subramanian R, Mullady EL, Caenepeel S, Freeman DJ, Wang L, Zhang N, Wu T, Hughes PE, Norman MH.

J Med Chem. 2012 Jun 14;55(11):5188-219. doi: 10.1021/jm300184s. Epub 2012 May 23.

PMID:
22548365
[PubMed - indexed for MEDLINE]
14.

Early pregnancy soluble E-selectin concentrations and risk of preeclampsia.

Carty DM, Anderson LA, Freeman DJ, Welsh PI, Brennand JE, Dominiczak AF, Delles C.

J Hypertens. 2012 May;30(5):954-9. doi: 10.1097/HJH.0b013e328352573b.

PMID:
22441350
[PubMed - indexed for MEDLINE]
15.

Structure-activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: investigations of various 6,5-heterocycles to improve metabolic stability.

Stec MM, Andrews KL, Booker SK, Caenepeel S, Freeman DJ, Jiang J, Liao H, McCarter J, Mullady EL, San Miguel T, Subramanian R, Tamayo N, Wang L, Yang K, Zalameda LP, Zhang N, Hughes PE, Norman MH.

J Med Chem. 2011 Jul 28;54(14):5174-84. doi: 10.1021/jm2004442. Epub 2011 Jun 29.

PMID:
21714526
[PubMed - indexed for MEDLINE]
16.

Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis.

Meyer zu Schwabedissen HE, Ware JA, Finkelstein D, Chaudhry AS, Mansell S, Leon-Ponte M, Strom SC, Zaher H, Schwarz UI, Freeman DJ, Schuetz EG, Tirona RG, Kim RB.

Hepatology. 2011 Aug;54(2):644-54. doi: 10.1002/hep.24391. Epub 2011 Jun 26.

PMID:
21538436
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna.

Cutler MJ, Urquhart BL, Velenosi TJ, Meyer Zu Schwabedissen HE, Dresser GK, Leake BF, Tirona RG, Kim RB, Freeman DJ.

J Clin Pharmacol. 2012 Apr;52(4):530-42. doi: 10.1177/0091270011400414. Epub 2011 Apr 19.

PMID:
21505084
[PubMed - indexed for MEDLINE]
18.

Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).

Freeman DJ, Robertson M, Brown EA, Rumley A, Tobias ES, Frölich M, Slagboom PE, Jukema JW, de Craen AJ, Sattar N, Ford I, Gaw A, Greer IA, Lowe GD, Stott DJ.

BMC Geriatr. 2011 Feb 22;11:8. doi: 10.1186/1471-2318-11-8.

PMID:
21342490
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Erythropoietin encapsulation in chitosan nanoparticles and kinetics of drug release.

Bokharaei M, Margaritis A, Xenocostas A, Freeman DJ.

Curr Drug Deliv. 2011 Mar;8(2):164-71.

PMID:
21235481
[PubMed - indexed for MEDLINE]
20.

Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring.

Jarvie E, Hauguel-de-Mouzon S, Nelson SM, Sattar N, Catalano PM, Freeman DJ.

Clin Sci (Lond). 2010 Apr 28;119(3):123-9. doi: 10.1042/CS20090640.

PMID:
20443782
[PubMed - indexed for MEDLINE]
Free PMC Article

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