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Optogenetic apoptosis: light-triggered cell death.

Hughes RM, Freeman DJ, Lamb KN, Pollet RM, Smith WJ, Lawrence DS.

Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12064-8. doi: 10.1002/anie.201506346. Epub 2015 Aug 25.


Differential expression of microRNA-206 and its target genes in preeclampsia.

Akehurst C, Small HY, Sharafetdinova L, Forrest R, Beattie W, Brown CE, Robinson SW, McClure JD, Work LM, Carty DM, McBride MW, Freeman DJ, Delles C.

J Hypertens. 2015 Oct;33(10):2068-74. doi: 10.1097/HJH.0000000000000656.


Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer.

Mendell J, Freeman DJ, Feng W, Hettmann T, Schneider M, Blum S, Ruhe J, Bange J, Nakamaru K, Chen S, Tsuchihashi Z, von Pawel J, Copigneaux C, Beckman RA.

EBioMedicine. 2015 Feb 12;2(3):264-71. doi: 10.1016/j.ebiom.2015.02.005. eCollection 2015 Mar.


Enzymatic and non-enzymatic mechanisms of dimesna metabolism.

Cutler MJ, Velenosi TJ, Bodalia A, House AA, Urquhart BL, Freeman DJ.

Amino Acids. 2015 Mar;47(3):511-23. doi: 10.1007/s00726-014-1882-0. Epub 2014 Dec 10.


Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother-offspring pairs: findings from a prospective pregnancy cohort.

Lawlor DA, West J, Fairley L, Nelson SM, Bhopal RS, Tuffnell D, Freeman DJ, Wright J, Whitelaw DC, Sattar N.

Diabetologia. 2014 Dec;57(12):2492-500. doi: 10.1007/s00125-014-3386-6. Epub 2014 Oct 3.


In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy.

Huda SS, Forrest R, Paterson N, Jordan F, Sattar N, Freeman DJ.

Hypertension. 2014 May;63(5):1094-101. doi: 10.1161/HYPERTENSIONAHA.113.01824. Epub 2014 Mar 3.


Co-occurrence of anaerobic bacteria in colorectal carcinomas.

Warren RL, Freeman DJ, Pleasance S, Watson P, Moore RA, Cochrane K, Allen-Vercoe E, Holt RA.

Microbiome. 2013 May 15;1(1):16. doi: 10.1186/2049-2618-1-16.


A phase 2 randomized trial of paclitaxel and carboplatin with or without panitumumab for first-line treatment of advanced non-small-cell lung cancer.

Crawford J, Swanson P, Schwarzenberger P, Sandler A, Prager D, Zhang K, Freeman DJ, Johnson CW, Krishnan K, Johnson D.

J Thorac Oncol. 2013 Dec;8(12):1510-8. doi: 10.1097/JTO.0b013e3182a7d1da.


Gene expression profiles can predict panitumumab monotherapy responsiveness in human tumor xenograft models.

Boedigheimer MJ, Freeman DJ, Kiaei P, Damore MA, Radinsky R.

Neoplasia. 2013 Feb;15(2):125-32.


Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester.

Meyer BJ, Stewart FM, Brown EA, Cooney J, Nilsson S, Olivecrona G, Ramsay JE, Griffin BA, Caslake MJ, Freeman DJ.

J Clin Endocrinol Metab. 2013 Feb;98(2):643-52. doi: 10.1210/jc.2012-3481. Epub 2013 Jan 21.


Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies.

Hodson L, Neville M, Chong MF, Rogers I, Huda SS, Freeman DJ, Frayn KN, Fielding BA.

Nutr Metab Cardiovasc Dis. 2013 Nov;23(11):1128-33. doi: 10.1016/j.numecd.2012.11.003. Epub 2012 Dec 8.


Derivation of HLA types from shotgun sequence datasets.

Warren RL, Choe G, Freeman DJ, Castellarin M, Munro S, Moore R, Holt RA.

Genome Med. 2012 Dec 10;4(12):95. doi: 10.1186/gm396. eCollection 2012.


Endothelial FOS expression and pre-eclampsia.

Mackenzie RM, Sandrim VC, Carty DM, McClure JD, Freeman DJ, Dominiczak AF, McBride MW, Delles C.

BJOG. 2012 Dec;119(13):1564-71. doi: 10.1111/1471-0528.12016. Epub 2012 Nov 2.


Preeclampsia is associated with compromised maternal synthesis of long-chain polyunsaturated fatty acids, leading to offspring deficiency.

Mackay VA, Huda SS, Stewart FM, Tham K, McKenna LA, Martin I, Jordan F, Brown EA, Hodson L, Greer IA, Meyer BJ, Freeman DJ.

Hypertension. 2012 Oct;60(4):1078-85. doi: 10.1161/HYPERTENSIONAHA.112.197897. Epub 2012 Sep 4.


Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.

Norman MH, Andrews KL, Bo YY, Booker SK, Caenepeel S, Cee VJ, D'Angelo ND, Freeman DJ, Herberich BJ, Hong FT, Jackson CL, Jiang J, Lanman BA, Liu L, McCarter JD, Mullady EL, Nishimura N, Pettus LH, Reed AB, Miguel TS, Smith AL, Stec MM, Tadesse S, Tasker A, Aidasani D, Zhu X, Subramanian R, Tamayo NA, Wang L, Whittington DA, Wu B, Wu T, Wurz RP, Yang K, Zalameda L, Zhang N, Hughes PE.

J Med Chem. 2012 Sep 13;55(17):7796-816. doi: 10.1021/jm300846z. Epub 2012 Aug 30. Erratum in: J Med Chem. 2012 Oct 25;55(20):8975.


Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.

Wurz RP, Liu L, Yang K, Nishimura N, Bo Y, Pettus LH, Caenepeel S, Freeman DJ, McCarter JD, Mullady EL, Miguel TS, Wang L, Zhang N, Andrews KL, Whittington DA, Jiang J, Subramanian R, Hughes PE, Norman MH.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5714-20. doi: 10.1016/j.bmcl.2012.06.078. Epub 2012 Jul 3.


Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer.

Freeman DJ, McDorman K, Ogbagabriel S, Kozlosky C, Yang BB, Doshi S, Perez-Ruxio JJ, Fanslow W, Starnes C, Radinsky R.

Mol Cancer. 2012 Jul 25;11:47. doi: 10.1186/1476-4598-11-47.


Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.

Smith AL, D'Angelo ND, Bo YY, Booker SK, Cee VJ, Herberich B, Hong FT, Jackson CL, Lanman BA, Liu L, Nishimura N, Pettus LH, Reed AB, Tadesse S, Tamayo NA, Wurz RP, Yang K, Andrews KL, Whittington DA, McCarter JD, Miguel TS, Zalameda L, Jiang J, Subramanian R, Mullady EL, Caenepeel S, Freeman DJ, Wang L, Zhang N, Wu T, Hughes PE, Norman MH.

J Med Chem. 2012 Jun 14;55(11):5188-219. doi: 10.1021/jm300184s. Epub 2012 May 23.


Early pregnancy soluble E-selectin concentrations and risk of preeclampsia.

Carty DM, Anderson LA, Freeman DJ, Welsh PI, Brennand JE, Dominiczak AF, Delles C.

J Hypertens. 2012 May;30(5):954-9. doi: 10.1097/HJH.0b013e328352573b.


Structure-activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: investigations of various 6,5-heterocycles to improve metabolic stability.

Stec MM, Andrews KL, Booker SK, Caenepeel S, Freeman DJ, Jiang J, Liao H, McCarter J, Mullady EL, San Miguel T, Subramanian R, Tamayo N, Wang L, Yang K, Zalameda LP, Zhang N, Hughes PE, Norman MH.

J Med Chem. 2011 Jul 28;54(14):5174-84. doi: 10.1021/jm2004442. Epub 2011 Jun 29.

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