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Items: 1 to 20 of 52


Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk.

Tehranchi AK, Myrthil M, Martin T, Hie BL, Golan D, Fraser HB.

Cell. 2016 Apr 21;165(3):730-41. doi: 10.1016/j.cell.2016.03.041. Epub 2016 Apr 14.


Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation.

Naranjo S, Smith JD, Artieri CG, Zhang M, Zhou Y, Palmer ME, Fraser HB.

PLoS Genet. 2015 Dec 29;11(12):e1005751. doi: 10.1371/journal.pgen.1005751. eCollection 2015 Dec.


Disentangling Sources of Selection on Exonic Transcriptional Enhancers.

Agoglia RM, Fraser HB.

Mol Biol Evol. 2016 Feb;33(2):585-90. doi: 10.1093/molbev/msv234. Epub 2015 Oct 24.


A pooling-based approach to mapping genetic variants associated with DNA methylation.

Kaplow IM, MacIsaac JL, Mah SM, McEwen LM, Kobor MS, Fraser HB.

Genome Res. 2015 Jun;25(6):907-17. doi: 10.1101/gr.183749.114. Epub 2015 Apr 24.


Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos.

McCoy RC, Demko Z, Ryan A, Banjevic M, Hill M, Sigurjonsson S, Rabinowitz M, Fraser HB, Petrov DA.

Science. 2015 Apr 10;348(6231):235-8. doi: 10.1126/science.aaa3337.


Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse.

Babak T, DeVeale B, Tsang EK, Zhou Y, Li X, Smith KS, Kukurba KR, Zhang R, Li JB, van der Kooy D, Montgomery SB, Fraser HB.

Nat Genet. 2015 May;47(5):544-9. doi: 10.1038/ng.3274. Epub 2015 Apr 13.


Discordance of DNA methylation variance between two accessible human tissues.

Jiang R, Jones MJ, Chen E, Neumann SM, Fraser HB, Miller GE, Kobor MS.

Sci Rep. 2015 Feb 9;5:8257. doi: 10.1038/srep08257.


Accounting for biases in riboprofiling data indicates a major role for proline in stalling translation.

Artieri CG, Fraser HB.

Genome Res. 2014 Dec;24(12):2011-21. doi: 10.1101/gr.175893.114. Epub 2014 Oct 7.


Transcript length mediates developmental timing of gene expression across Drosophila.

Artieri CG, Fraser HB.

Mol Biol Evol. 2014 Nov;31(11):2879-89. doi: 10.1093/molbev/msu226. Epub 2014 Jul 28.


Evolution at two levels of gene expression in yeast.

Artieri CG, Fraser HB.

Genome Res. 2014 Mar;24(3):411-21. doi: 10.1101/gr.165522.113. Epub 2013 Dec 6.


The molecular mechanism of a cis-regulatory adaptation in yeast.

Chang J, Zhou Y, Hu X, Lam L, Henry C, Green EM, Kita R, Kobor MS, Fraser HB.

PLoS Genet. 2013;9(9):e1003813. doi: 10.1371/journal.pgen.1003813. Epub 2013 Sep 19.


A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers.

Smith JD, McManus KF, Fraser HB.

Mol Biol Evol. 2013 Nov;30(11):2509-18. doi: 10.1093/molbev/mst134. Epub 2013 Jul 30.


Ancient cis-regulatory constraints and the evolution of genome architecture.

Irimia M, Maeso I, Roy SW, Fraser HB.

Trends Genet. 2013 Sep;29(9):521-8. doi: 10.1016/j.tig.2013.05.008. Epub 2013 Jun 18. Review.


Reply to Suderman et al.: Importance of accounting for blood cell composition in epigenetic studies.

Lam LL, Emberly E, Fraser HB, Neumann SM, Chen E, Miller GE, Kobor MS.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):E1247. No abstract available.


Gene expression drives local adaptation in humans.

Fraser HB.

Genome Res. 2013 Jul;23(7):1089-96. doi: 10.1101/gr.152710.112. Epub 2013 Mar 28.


Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression.

Ariza-Cosano A, Visel A, Pennacchio LA, Fraser HB, Gómez-Skarmeta JL, Irimia M, Bessa J.

BMC Genomics. 2012 Dec 19;13:713. doi: 10.1186/1471-2164-13-713.


Factors underlying variable DNA methylation in a human community cohort.

Lam LL, Emberly E, Fraser HB, Neumann SM, Chen E, Miller GE, Kobor MS.

Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2:17253-60. doi: 10.1073/pnas.1121249109. Epub 2012 Oct 8.


Extensive conservation of ancient microsynteny across metazoans due to cis-regulatory constraints.

Irimia M, Tena JJ, Alexis MS, Fernandez-Miñan A, Maeso I, Bogdanovic O, de la Calle-Mustienes E, Roy SW, Gómez-Skarmeta JL, Fraser HB.

Genome Res. 2012 Dec;22(12):2356-67. doi: 10.1101/gr.139725.112. Epub 2012 Jun 21.


Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity.

Fraser HB, Levy S, Chavan A, Shah HB, Perez JC, Zhou Y, Siegal ML, Sinha H.

Genome Res. 2012 Oct;22(10):1930-9. doi: 10.1101/gr.134080.111. Epub 2012 May 29.

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