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Results: 1 to 20 of 37


Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.

Tyzack GE, Sitnikov S, Barson D, Adams-Carr KL, Lau NK, Kwok JC, Zhao C, Franklin RJ, Karadottir RT, Fawcett JW, Lakatos A.

Nat Commun. 2014 Jul 11;5:4294. doi: 10.1038/ncomms5294.


Auxetic nuclei in embryonic stem cells exiting pluripotency.

Pagliara S, Franze K, McClain CR, Wylde GW, Fisher CL, Franklin RJ, Kabla AJ, Keyser UF, Chalut KJ.

Nat Mater. 2014 Jun;13(6):638-44. doi: 10.1038/nmat3943. Epub 2014 Apr 20.


Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.

Lundgaard I, Luzhynskaya A, Stockley JH, Wang Z, Evans KA, Swire M, Volbracht K, Gautier HO, Franklin RJ; Charles Ffrench-Constant, Attwell D, Káradóttir RT.

PLoS Biol. 2013 Dec;11(12):e1001743. doi: 10.1371/journal.pbio.1001743. Epub 2013 Dec 31.


Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis.

Hampton DW, Serio A, Pryce G, Al-Izki S, Franklin RJ, Giovannoni G, Baker D, Chandran S.

Acta Neuropathol Commun. 2013 Dec 23;1:84. doi: 10.1186/2051-5960-1-84.


Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination.

Syed YA, Baer A, Hofer MP, González GA, Rundle J, Myrta S, Huang JK, Zhao C, Rossner MJ, Trotter MW, Lubec G, Franklin RJ, Kotter MR.

EMBO Mol Med. 2013 Dec;5(12):1918-34. doi: 10.1002/emmm.201303123. Epub 2013 Oct 21.


High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology.

Stacpoole SR, Spitzer S, Bilican B, Compston A, Karadottir R, Chandran S, Franklin RJ.

Stem Cell Reports. 2013 Oct 31;1(5):437-50. doi: 10.1016/j.stemcr.2013.09.006. eCollection 2013.


M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.

Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, van Wijngaarden P, Wagers AJ, Williams A, Franklin RJ, ffrench-Constant C.

Nat Neurosci. 2013 Sep;16(9):1211-8. doi: 10.1038/nn.3469. Epub 2013 Jul 21.


The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche.

Kazanis I, Gorenkova N, Zhao JW, Franklin RJ, Modo M, Ffrench-Constant C.

Exp Neurol. 2013 Oct;248:387-97. doi: 10.1016/j.expneurol.2013.06.025. Epub 2013 Jul 2.


Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation.

Stacpoole SR, Webber DJ, Bilican B, Compston A, Chandran S, Franklin RJ.

Stem Cells Transl Med. 2013 Jun;2(6):464-72. doi: 10.5966/sctm.2012-0144. Epub 2013 May 15.


Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination.

Yuen TJ, Johnson KR, Miron VE, Zhao C, Quandt J, Harrisingh MC, Swire M, Williams A, McFarland HF, Franklin RJ, Ffrench-Constant C.

Brain. 2013 Apr;136(Pt 4):1035-47. doi: 10.1093/brain/awt024. Epub 2013 Mar 21.


Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model.

Granger N, Blamires H, Franklin RJ, Jeffery ND.

Brain. 2012 Nov;135(Pt 11):3227-37. doi: 10.1093/brain/aws268.


Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z.

Huang JK, Ferrari CC, Monteiro de Castro G, Lafont D, Zhao C, Zaratin P, Pouly S, Greco B, Franklin RJ.

Am J Pathol. 2012 Nov;181(5):1518-23. doi: 10.1016/j.ajpath.2012.07.011. Epub 2012 Aug 31.


Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.

Holdsworth G, Slocombe P, Doyle C, Sweeney B, Veverka V, Le Riche K, Franklin RJ, Compson J, Brookings D, Turner J, Kennedy J, Garlish R, Shi J, Newnham L, McMillan D, Muzylak M, Carr MD, Henry AJ, Ceska T, Robinson MK.

J Biol Chem. 2012 Aug 3;287(32):26464-77. doi: 10.1074/jbc.M112.350108. Epub 2012 Jun 13.


Rejuvenation of regeneration in the aging central nervous system.

Ruckh JM, Zhao JW, Shadrach JL, van Wijngaarden P, Rao TN, Wagers AJ, Franklin RJ.

Cell Stem Cell. 2012 Jan 6;10(1):96-103. doi: 10.1016/j.stem.2011.11.019.


Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination.

Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1299-304. doi: 10.1073/pnas.1113540109. Epub 2011 Dec 12.


Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.

Huang JK, Fancy SP, Zhao C, Rowitch DH, Ffrench-Constant C, Franklin RJ.

Neurotherapeutics. 2011 Oct;8(4):650-8. doi: 10.1007/s13311-011-0065-x. Review.


Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.

Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S.

Nat Protoc. 2011 Jul 28;6(8):1229-40. doi: 10.1038/nprot.2011.380.


Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.

Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH.

Nat Neurosci. 2011 Jun 26;14(8):1009-16. doi: 10.1038/nn.2855.


Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis.

Zambonin JL, Zhao C, Ohno N, Campbell GR, Engeham S, Ziabreva I, Schwarz N, Lee SE, Frischer JM, Turnbull DM, Trapp BD, Lassmann H, Franklin RJ, Mahad DJ.

Brain. 2011 Jul;134(Pt 7):1901-13. doi: 10.1093/brain/awr110.


Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation.

Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S.

Cell Death Differ. 2011 Jun;18(6):1016-23. doi: 10.1038/cdd.2010.171. Epub 2011 Jan 28.

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