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Results: 1 to 20 of 124

1.

Unraveling genetic modifiers in the gria4 mouse model of absence epilepsy.

Frankel WN, Mahaffey CL, McGarr TC, Beyer BJ, Letts VA.

PLoS Genet. 2014 Jul 10;10(7):e1004454. doi: 10.1371/journal.pgen.1004454. eCollection 2014 Jul.

PMID:
25010494
[PubMed - in process]
Free PMC Article
2.

Antiepileptic activity of preferential inhibitors of persistent sodium current.

Anderson LL, Thompson CH, Hawkins NA, Nath RD, Petersohn AA, Rajamani S, Bush WS, Frankel WN, Vanoye CG, Kearney JA, George AL Jr.

Epilepsia. 2014 Aug;55(8):1274-83. doi: 10.1111/epi.12657. Epub 2014 May 23.

PMID:
24862204
[PubMed - in process]
3.

Hidden in plain sight: spike-wave discharges in mouse inbred strains.

Letts VA, Beyer BJ, Frankel WN.

Genes Brain Behav. 2014 Jul;13(6):519-26. doi: 10.1111/gbb.12142. Epub 2014 Jun 16.

PMID:
24861780
[PubMed - in process]
4.

Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy.

Oliva MK, McGarr TC, Beyer BJ, Gazina E, Kaplan DI, Cordeiro L, Thomas E, Dib-Hajj SD, Waxman SG, Frankel WN, Petrou S.

Neurobiol Dis. 2014 Jul;67:180-90. doi: 10.1016/j.nbd.2014.03.007. Epub 2014 Mar 19.

PMID:
24657915
[PubMed - in process]
5.

Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures.

Zhang W, Peterson M, Beyer B, Frankel WN, Zhang ZW.

J Neurosci. 2014 Feb 12;34(7):2754-63. doi: 10.1523/JNEUROSCI.4900-12.2014.

PMID:
24523563
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.

Neef J, Jung S, Wong AB, Reuter K, Pangrsic T, Chakrabarti R, Kügler S, Lenz C, Nouvian R, Boumil RM, Frankel WN, Wichmann C, Moser T.

J Neurosci. 2014 Jan 15;34(3):705-16. doi: 10.1523/JNEUROSCI.3313-13.2014.

PMID:
24431429
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development.

Park HJ, Hong M, Bronson RT, Israel MA, Frankel WN, Yun K.

Stem Cells. 2013 May;31(5):1010-21. doi: 10.1002/stem.1351.

PMID:
23390122
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function.

Wagnon JL, Briese M, Sun W, Mahaffey CL, Curk T, Rot G, Ule J, Frankel WN.

PLoS Genet. 2012;8(11):e1003067. doi: 10.1371/journal.pgen.1003067. Epub 2012 Nov 29.

PMID:
23209433
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice.

Sun W, Wagnon JL, Mahaffey CL, Briese M, Ule J, Frankel WN.

J Physiol. 2013 Jan 1;591(Pt 1):241-55. doi: 10.1113/jphysiol.2012.240168. Epub 2012 Oct 22.

PMID:
23090952
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The genomic landscape shaped by selection on transposable elements across 18 mouse strains.

Nellåker C, Keane TM, Yalcin B, Wong K, Agam A, Belgard TG, Flint J, Adams DJ, Frankel WN, Ponting CP.

Genome Biol. 2012 Jun 15;13(6):R45. doi: 10.1186/gb-2012-13-6-r45.

PMID:
22703977
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy.

Paz JT, Bryant AS, Peng K, Fenno L, Yizhar O, Frankel WN, Deisseroth K, Huguenard JR.

Nat Neurosci. 2011 Aug 21;14(9):1167-73. doi: 10.1038/nn.2896.

PMID:
21857658
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Etiology of a genetically complex seizure disorder in Celf4 mutant mice.

Wagnon JL, Mahaffey CL, Sun W, Yang Y, Chao HT, Frankel WN.

Genes Brain Behav. 2011 Oct;10(7):765-77. doi: 10.1111/j.1601-183X.2011.00717.x. Epub 2011 Aug 3.

PMID:
21745337
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice.

Tokuda S, Mahaffey CL, Monks B, Faulkner CR, Birnbaum MJ, Danzer SC, Frankel WN.

Hum Mol Genet. 2011 Mar 1;20(5):988-99. doi: 10.1093/hmg/ddq544. Epub 2010 Dec 15.

PMID:
21159799
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

Hawkins NA, Martin MS, Frankel WN, Kearney JA, Escayg A.

Neurobiol Dis. 2011 Mar;41(3):655-60. doi: 10.1016/j.nbd.2010.11.016. Epub 2010 Dec 13.

PMID:
21156207
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice.

Boumil RM, Letts VA, Roberts MC, Lenz C, Mahaffey CL, Zhang ZW, Moser T, Frankel WN.

PLoS Genet. 2010 Aug 5;6(8). pii: e1001046. doi: 10.1371/journal.pgen.1001046.

PMID:
20700442
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Genetics of complex neurological disease: challenges and opportunities for modeling epilepsy in mice and rats.

Frankel WN.

Trends Genet. 2009 Aug;25(8):361-7. doi: 10.1016/j.tig.2009.07.001. Epub 2009 Aug 6. Review.

PMID:
19665252
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Szt2, a novel gene for seizure threshold in mice.

Frankel WN, Yang Y, Mahaffey CL, Beyer BJ, O'Brien TP.

Genes Brain Behav. 2009 Jul;8(5):568-76. doi: 10.1111/j.1601-183X.2009.00509.x.

PMID:
19624305
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice.

Papale LA, Beyer B, Jones JM, Sharkey LM, Tufik S, Epstein M, Letts VA, Meisler MH, Frankel WN, Escayg A.

Hum Mol Genet. 2009 May 1;18(9):1633-41. doi: 10.1093/hmg/ddp081. Epub 2009 Mar 2.

PMID:
19254928
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Genetic complexity of absence seizures in substrains of C3H mice.

Tokuda S, Beyer BJ, Frankel WN.

Genes Brain Behav. 2009 Apr;8(3):283-9. doi: 10.1111/j.1601-183X.2008.00472.x. Epub 2009 Dec 17.

PMID:
19170754
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A targeted deleterious allele of the splicing factor SCNM1 in the mouse.

Howell VM, de Haan G, Bergren S, Jones JM, Culiat CT, Michaud EJ, Frankel WN, Meisler MH.

Genetics. 2008 Nov;180(3):1419-27. doi: 10.1534/genetics.108.094227. Epub 2008 Sep 14.

PMID:
18791226
[PubMed - indexed for MEDLINE]
Free PMC Article

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