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Results: 1 to 20 of 184


Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs.

Nüsgen N, Goering W, Dauksa A, Biswas A, Jamil MA, Dimitriou I, Sharma A, Singer H, Fimmers R, Fröhlich H, Oldenburg J, Gulbinas A, Schulz WA, El-Maarri O.

Clin Epigenetics. 2015 Mar 1;7(1):17. doi: 10.1186/s13148-015-0051-y. eCollection 2015.


Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.

Kim S, Becker J, Bechheim M, Kaiser V, Noursadeghi M, Fricker N, Beier E, Klaschik S, Boor P, Hess T, Hofmann A, Holdenrieder S, Wendland JR, Fröhlich H, Hartmann G, Nöthen MM, Müller-Myhsok B, Pütz B, Hornung V, Schumacher J.

Nat Commun. 2014 Oct 20;5:5236. doi: 10.1038/ncomms6236.


Kit transduced signals counteract erythroid maturation by MAPK-dependent modulation of erythropoietin signaling and apoptosis induction in mouse fetal liver.

Haas N, Riedt T, Labbaf Z, Baßler K, Gergis D, Fröhlich H, Gütgemann I, Janzen V, Schorle H.

Cell Death Differ. 2014 Oct 17. doi: 10.1038/cdd.2014.172. [Epub ahead of print]


Activation of AMP-activated protein kinase sensitizes lung cancer cells and H1299 xenografts to erlotinib.

Hülsmann HJ, Rolff J, Bender C, Jarahian M, Korf U, Herwig R, Fröhlich H, Thomas M, Merk J, Fichtner I, Sültmann H, Kuner R.

Lung Cancer. 2014 Nov;86(2):151-7. doi: 10.1016/j.lungcan.2014.09.001. Epub 2014 Sep 10.


Genome-wide CNV analysis in 221 unrelated patients and targeted high-throughput sequencing reveal novel causative candidate genes for colorectal adenomatous polyposis.

Horpaopan S, Spier I, Zink AM, Altmüller J, Holzapfel S, Laner A, Vogt S, Uhlhaas S, Heilmann S, Stienen D, Pasternack SM, Keppler K, Adam R, Kayser K, Moebus S, Draaken M, Degenhardt F, Engels H, Hofmann A, Nöthen MM, Steinke V, Perez-Bouza A, Herms S, Holinski-Feder E, Fröhlich H, Thiele H, Hoffmann P, Aretz S.

Int J Cancer. 2015 Mar 15;136(6):E578-89. doi: 10.1002/ijc.29215. Epub 2014 Sep 30.


CD4+ T cell counts reflect the immunosuppressive state of CD4 helper cells in patients after allogeneic stem cell transplantation.

Holtick U, Frenzel LP, Shimabukuro-Vornhagen A, Theurich S, Claasen J, Scheid C, von Bergwelt-Baildon M, Fröhlich H, Wendtner CM, Chemnitz JM.

Ann Hematol. 2015 Jan;94(1):129-37. doi: 10.1007/s00277-014-2166-1. Epub 2014 Aug 15.


Different microRNA profiles in chronic epilepsy versus acute seizure mouse models.

Kretschmann A, Danis B, Andonovic L, Abnaof K, van Rikxoort M, Siegel F, Mazzuferi M, Godard P, Hanon E, Fröhlich H, Kaminski RM, Foerch P, Pfeifer A.

J Mol Neurosci. 2015 Feb;55(2):466-79. doi: 10.1007/s12031-014-0368-6. Epub 2014 Jul 31.


Minimal important difference for 6-minute walk test distances among patients with chronic heart failure.

Täger T, Hanholz W, Cebola R, Fröhlich H, Franke J, Doesch A, Katus HA, Wians FH Jr, Frankenstein L.

Int J Cardiol. 2014 Sep;176(1):94-8. doi: 10.1016/j.ijcard.2014.06.035. Epub 2014 Jul 1.


TGF-β stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level.

Abnaof K, Mallela N, Walenda G, Meurer SK, Seré K, Lin Q, Smeets B, Hoffmann K, Wagner W, Zenke M, Weiskirchen R, Fröhlich H.

BMC Syst Biol. 2014 May 15;8:55. doi: 10.1186/1752-0509-8-55.


Evidence for contribution of epigenetic mechanisms in the pathogenesis of systemic mast cell activation disease.

Haenisch B, Fröhlich H, Herms S, Molderings GJ.

Immunogenetics. 2014 May;66(5):287-97. doi: 10.1007/s00251-014-0768-3. Epub 2014 Mar 14.


netClass: an R-package for network based, integrative biomarker signature discovery.

Cun Y, Fröhlich H.

Bioinformatics. 2014 May 1;30(9):1325-6. doi: 10.1093/bioinformatics/btu025. Epub 2014 Jan 17.


Including network knowledge into Cox regression models for biomarker signature discovery.

Fröhlich H.

Biom J. 2014 Mar;56(2):287-306. doi: 10.1002/bimj.201300035. Epub 2014 Jan 15.


NSCLC cells adapted to EGFR inhibition accumulate EGFR interacting proteins and down-regulate microRNA related to epithelial-mesenchymal transition.

Mader RM, Foerster S, Sarin N, Michaelis M, Cinatl J Jr, Kloft C, Fröhlich H, Engel F, Kalayda GV, Jäger W, Frötschl R, Jaehde U, Ritter CA.

Int J Clin Pharmacol Ther. 2014 Jan;52(1):92-4. doi: 10.5414/CPXCES13EA08. No abstract available.


A systems pharmacology approach to improve drug therapy in NSCLC: establishing a CESAR network.

Kalayda GV, Michaelis M, Cinatl J Jr, Mader RM, Fröhlich H, Sarin N, Melin J, Engel F, Jäger W, Frötschl R, Jaehde U, Kloft C, Ritter CA.

Int J Clin Pharmacol Ther. 2014 Jan;52(1):89-91. doi: 10.5414/CPXCES13EA07. No abstract available.


TGF-beta1 does not induce senescence of multipotent mesenchymal stromal cells and has similar effects in early and late passages.

Walenda G, Abnaof K, Joussen S, Meurer S, Smeets H, Rath B, Hoffmann K, Fröhlich H, Zenke M, Weiskirchen R, Wagner W.

PLoS One. 2013 Oct 17;8(10):e77656. doi: 10.1371/journal.pone.0077656. eCollection 2013.


Unsupervised automated high throughput phenotyping of RNAi time-lapse movies.

Failmezger H, Fröhlich H, Tresch A.

BMC Bioinformatics. 2013 Oct 4;14:292. doi: 10.1186/1471-2105-14-292.


Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells.

Nokhbehsaim M, Eick S, Nogueira AV, Hoffmann P, Herms S, Fröhlich H, Jepsen S, Jäger A, Cirelli JA, Deschner J.

Mediators Inflamm. 2013;2013:437123. doi: 10.1155/2013/437123. Epub 2013 Aug 22.


Network and data integration for biomarker signature discovery via network smoothed T-statistics.

Cun Y, Fröhlich H.

PLoS One. 2013 Sep 3;8(9):e73074. doi: 10.1371/journal.pone.0073074. eCollection 2013.


Boosting probabilistic graphical model inference by incorporating prior knowledge from multiple sources.

Praveen P, Fröhlich H.

PLoS One. 2013 Jun 24;8(6):e67410. doi: 10.1371/journal.pone.0067410. Print 2013.


Thrombin-sensitive expression of the store operated Ca(2+) channel Orai1 in platelets.

Münzer P, Tolios A, Pelzl L, Schmid E, Schmidt EM, Walker B, Fröhlich H, Borst O, Gawaz M, Lang F.

Biochem Biophys Res Commun. 2013 Jun 21;436(1):25-30. doi: 10.1016/j.bbrc.2013.05.031. Epub 2013 May 16.

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