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Items: 1 to 20 of 198

1.

Utilising the EGFR interactome to identify mechanisms of drug resistance in non-small cell lung cancer - Proof of concept towards a systems pharmacology approach.

Saafan H, Foerster S, Parra-Guillen ZP, Hammer E, Michaelis M, Cinatl J Jr, Völker U, Fröhlich H, Kloft C, Ritter CA.

Eur J Pharm Sci. 2016 Apr 23. pii: S0928-0987(16)30131-2. doi: 10.1016/j.ejps.2016.04.025. [Epub ahead of print]

PMID:
27112992
2.

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.

Allen GI, Amoroso N, Anghel C, Balagurusamy V, Bare CJ, Beaton D, Bellotti R, Bennett DA, Boehme KL, Boutros PC, Caberlotto L, Caloian C, Campbell F, Chaibub Neto E, Chang YC, Chen B, Chen CY, Chien TY, Clark T, Das S, Davatzikos C, Deng J, Dillenberger D, Dobson RJ, Dong Q, Doshi J, Duma D, Errico R, Erus G, Everett E, Fardo DW, Friend SH, Fröhlich H, Gan J, St George-Hyslop P, Ghosh SS, Glaab E, Green RC, Guan Y, Hong MY, Huang C, Hwang J, Ibrahim J, Inglese P, Iyappan A, Jiang Q, Katsumata Y, Kauwe JS, Klein A, Kong D, Krause R, Lalonde E, Lauria M, Lee E, Lin X, Liu Z, Livingstone J, Logsdon BA, Lovestone S, Ma TW, Malhotra A, Mangravite LM, Maxwell TJ, Merrill E, Nagorski J, Namasivayam A, Narayan M, Naz M, Newhouse SJ, Norman TC, Nurtdinov RN, Oyang YJ, Pawitan Y, Peng S, Peters MA, Piccolo SR, Praveen P, Priami C, Sabelnykova VY, Senger P, Shen X, Simmons A, Sotiras A, Stolovitzky G, Tangaro S, Tateo A, Tung YA, Tustison NJ, Varol E, Vradenburg G, Weiner MW, Xiao G, Xie L, Xie Y, Xu J, Yang H, Zhan X, Zhou Y, Zhu F, Zhu H, Zhu S; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2016 Apr 11. pii: S1552-5260(16)00081-9. doi: 10.1016/j.jalz.2016.02.006. [Epub ahead of print]

3.

Learning (from) the errors of a systems biology model.

Engelhardt B, Frőhlich H, Kschischo M.

Sci Rep. 2016 Feb 11;6:20772. doi: 10.1038/srep20772.

4.

A Geometric Method for Model Reduction of Biochemical Networks with Polynomial Rate Functions.

Samal SS, Grigoriev D, Fröhlich H, Weber A, Radulescu O.

Bull Math Biol. 2015 Dec;77(12):2180-211. doi: 10.1007/s11538-015-0118-0. Epub 2015 Nov 23.

PMID:
26597097
5.

Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling.

Fröhlich H, Bahamondez G, Götschel F, Korf U.

PLoS One. 2015 Nov 16;10(11):e0142646. doi: 10.1371/journal.pone.0142646. eCollection 2015.

6.

Multidisciplinary Approach for Patients Hospitalized With Heart Failure.

Frankenstein L, Fröhlich H, Cleland JG.

Rev Esp Cardiol (Engl Ed). 2015 Oct;68(10):885-91. doi: 10.1016/j.rec.2015.05.008.

PMID:
26409892
7.

DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations.

Sharma A, Jamil MA, Nuesgen N, Schreiner F, Priebe L, Hoffmann P, Herns S, Nöthen MM, Fröhlich H, Oldenburg J, Woelfle J, El-Maarri O.

Clin Epigenetics. 2015 Jul 28;7(1):76. doi: 10.1186/s13148-015-0112-2. eCollection 2015.

8.

Carvedilol Compared With Metoprolol Succinate in the Treatment and Prognosis of Patients With Stable Chronic Heart Failure: Carvedilol or Metoprolol Evaluation Study.

Fröhlich H, Zhao J, Täger T, Cebola R, Schellberg D, Katus HA, Grundtvig M, Hole T, Atar D, Agewall S, Frankenstein L.

Circ Heart Fail. 2015 Sep;8(5):887-96. doi: 10.1161/CIRCHEARTFAILURE.114.001701. Epub 2015 Jul 14.

PMID:
26175538
9.

L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.

Schmitt I, Kaut O, Khazneh H, deBoni L, Ahmad A, Berg D, Klein C, Fröhlich H, Wüllner U.

Mov Disord. 2015 Nov;30(13):1794-801. doi: 10.1002/mds.26319. Epub 2015 Jul 14.

PMID:
26173746
10.

biRte: Bayesian inference of context-specific regulator activities and transcriptional networks.

Fröhlich H.

Bioinformatics. 2015 Oct 15;31(20):3290-8. doi: 10.1093/bioinformatics/btv379. Epub 2015 Jun 25.

PMID:
26112290
11.

Foxp1 regulates cortical radial migration and neuronal morphogenesis in developing cerebral cortex.

Li X, Xiao J, Fröhlich H, Tu X, Li L, Xu Y, Cao H, Qu J, Rappold GA, Chen JG.

PLoS One. 2015 May 26;10(5):e0127671. doi: 10.1371/journal.pone.0127671. eCollection 2015.

12.

Biological variation, reference change value (RCV) and minimal important difference (MID) of inspiratory muscle strength (PImax) in patients with stable chronic heart failure.

Täger T, Schell M, Cebola R, Fröhlich H, Dösch A, Franke J, Katus HA, Wians FH Jr, Frankenstein L.

Clin Res Cardiol. 2015 Oct;104(10):822-30. doi: 10.1007/s00392-015-0850-3. Epub 2015 Apr 18.

PMID:
25893567
13.

NEMix: single-cell nested effects models for probabilistic pathway stimulation.

Siebourg-Polster J, Mudrak D, Emmenlauer M, Rämö P, Dehio C, Greber U, Fröhlich H, Beerenwinkel N.

PLoS Comput Biol. 2015 Apr 16;11(4):e1004078. doi: 10.1371/journal.pcbi.1004078. eCollection 2015 Apr.

14.

Peritoneal ultrafiltration in end-stage chronic heart failure.

Fröhlich H, Katus HA, Täger T, Lossnitzer N, Grossekettler L, Kihm L, Zeier M, Remppis A, Frankenstein L, Schwenger V.

Clin Kidney J. 2015 Apr;8(2):219-25. doi: 10.1093/ckj/sfv007. Epub 2015 Feb 17.

15.

Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs.

Nüsgen N, Goering W, Dauksa A, Biswas A, Jamil MA, Dimitriou I, Sharma A, Singer H, Fimmers R, Fröhlich H, Oldenburg J, Gulbinas A, Schulz WA, El-Maarri O.

Clin Epigenetics. 2015 Mar 1;7(1):17. doi: 10.1186/s13148-015-0051-y. eCollection 2015.

16.

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.

Kim S, Becker J, Bechheim M, Kaiser V, Noursadeghi M, Fricker N, Beier E, Klaschik S, Boor P, Hess T, Hofmann A, Holdenrieder S, Wendland JR, Fröhlich H, Hartmann G, Nöthen MM, Müller-Myhsok B, Pütz B, Hornung V, Schumacher J.

Nat Commun. 2014 Oct 20;5:5236. doi: 10.1038/ncomms6236.

PMID:
25327457
17.

Kit transduced signals counteract erythroid maturation by MAPK-dependent modulation of erythropoietin signaling and apoptosis induction in mouse fetal liver.

Haas N, Riedt T, Labbaf Z, Baßler K, Gergis D, Fröhlich H, Gütgemann I, Janzen V, Schorle H.

Cell Death Differ. 2015 May;22(5):790-800. doi: 10.1038/cdd.2014.172. Epub 2014 Oct 17.

18.

Activation of AMP-activated protein kinase sensitizes lung cancer cells and H1299 xenografts to erlotinib.

Hülsmann HJ, Rolff J, Bender C, Jarahian M, Korf U, Herwig R, Fröhlich H, Thomas M, Merk J, Fichtner I, Sültmann H, Kuner R.

Lung Cancer. 2014 Nov;86(2):151-7. doi: 10.1016/j.lungcan.2014.09.001. Epub 2014 Sep 10.

PMID:
25240516
19.

Genome-wide CNV analysis in 221 unrelated patients and targeted high-throughput sequencing reveal novel causative candidate genes for colorectal adenomatous polyposis.

Horpaopan S, Spier I, Zink AM, Altmüller J, Holzapfel S, Laner A, Vogt S, Uhlhaas S, Heilmann S, Stienen D, Pasternack SM, Keppler K, Adam R, Kayser K, Moebus S, Draaken M, Degenhardt F, Engels H, Hofmann A, Nöthen MM, Steinke V, Perez-Bouza A, Herms S, Holinski-Feder E, Fröhlich H, Thiele H, Hoffmann P, Aretz S.

Int J Cancer. 2015 Mar 15;136(6):E578-89. doi: 10.1002/ijc.29215. Epub 2014 Sep 30.

20.

CD4+ T cell counts reflect the immunosuppressive state of CD4 helper cells in patients after allogeneic stem cell transplantation.

Holtick U, Frenzel LP, Shimabukuro-Vornhagen A, Theurich S, Claasen J, Scheid C, von Bergwelt-Baildon M, Fröhlich H, Wendtner CM, Chemnitz JM.

Ann Hematol. 2015 Jan;94(1):129-37. doi: 10.1007/s00277-014-2166-1. Epub 2014 Aug 15.

PMID:
25118994
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