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Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria.

Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ.

PLoS Pathog. 2015 Jun 26;11(6):e1005010. doi: 10.1371/journal.ppat.1005010. eCollection 2015 Jun.


The Spectrum of Drug Susceptibility in Mycobacteria.

Aldridge BB, Keren I, Fortune SM.

Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.MGM2-0031-2013.


The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions.

Datta P, Ravi J, Guerrini V, Chauhan R, Neiditch MB, Shell SS, Fortune SM, Hancioglu B, Igoshin OA, Gennaro ML.

Mol Microbiol. 2015 Apr 21. doi: 10.1111/mmi.13037. [Epub ahead of print]


DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader.

Rock JM, Lang UF, Chase MR, Ford CB, Gerrick ER, Gawande R, Coscolla M, Gagneux S, Fortune SM, Lamers MH.

Nat Genet. 2015 Jun;47(6):677-81. doi: 10.1038/ng.3269. Epub 2015 Apr 20.


RNA sequencing for transcript 5'-end mapping in mycobacteria.

Shell SS, Chase MR, Ioerger TR, Fortune SM.

Methods Mol Biol. 2015;1285:31-45. doi: 10.1007/978-1-4939-2450-9_3.


Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.

Gideon HP, Phuah J, Myers AJ, Bryson BD, Rodgers MA, Coleman MT, Maiello P, Rutledge T, Marino S, Fortune SM, Kirschner DE, Lin PL, Flynn JL.

PLoS Pathog. 2015 Jan 22;11(1):e1004603. doi: 10.1371/journal.ppat.1004603. eCollection 2015 Jan.


Linked domain architectures allow for specialization of function in the FtsK/SpoIIIE ATPases of ESX secretion systems.

Ramsdell TL, Huppert LA, Sysoeva TA, Fortune SM, Burton BM.

J Mol Biol. 2015 Mar 13;427(5):1119-32. doi: 10.1016/j.jmb.2014.06.013. Epub 2014 Jun 27.


The ESX system in Bacillus subtilis mediates protein secretion.

Huppert LA, Ramsdell TL, Chase MR, Sarracino DA, Fortune SM, Burton BM.

PLoS One. 2014 May 5;9(5):e96267. doi: 10.1371/journal.pone.0096267. eCollection 2014.


Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c.

Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, Rubin EJ, Alber T, Moody DB.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):2978-83. doi: 10.1073/pnas.1315883111. Epub 2014 Feb 10.


Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing.

Lin PL, Ford CB, Coleman MT, Myers AJ, Gawande R, Ioerger T, Sacchettini J, Fortune SM, Flynn JL.

Nat Med. 2014 Jan;20(1):75-9. doi: 10.1038/nm.3412. Epub 2013 Dec 15.


Persisters and beyond: mechanisms of phenotypic drug resistance and drug tolerance in bacteria.

Kester JC, Fortune SM.

Crit Rev Biochem Mol Biol. 2014 Mar-Apr;49(2):91-101. doi: 10.3109/10409238.2013.869543. Epub 2013 Dec 13. Review.


DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis.

Shell SS, Prestwich EG, Baek SH, Shah RR, Sassetti CM, Dedon PC, Fortune SM.

PLoS Pathog. 2013;9(7):e1003419. doi: 10.1371/journal.ppat.1003419. Epub 2013 Jul 4.


Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis.

Ford CB, Shah RR, Maeda MK, Gagneux S, Murray MB, Cohen T, Johnston JC, Gardy J, Lipsitch M, Fortune SM.

Nat Genet. 2013 Jul;45(7):784-90. doi: 10.1038/ng.2656. Epub 2013 Jun 9.


Magnetic barcode assay for genetic detection of pathogens.

Liong M, Hoang AN, Chung J, Gural N, Ford CB, Min C, Shah RR, Ahmad R, Fernandez-Suarez M, Fortune SM, Toner M, Lee H, Weissleder R.

Nat Commun. 2013;4:1752. doi: 10.1038/ncomms2745.


The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection.

Ragheb MN, Ford CB, Chase MR, Lin PL, Flynn JL, Fortune SM.

BMC Genomics. 2013 Mar 5;14:145. doi: 10.1186/1471-2164-14-145.


Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria.

Chao MC, Kieser KJ, Minami S, Mavrici D, Aldridge BB, Fortune SM, Alber T, Rubin EJ.

PLoS Pathog. 2013 Feb;9(2):e1003197. doi: 10.1371/journal.ppat.1003197. Epub 2013 Feb 28.


Decoupling directed and passive motion in dynamic systems: particle tracking microrheology of sputum.

Fong EJ, Sharma Y, Fallica B, Tierney DB, Fortune SM, Zaman MH.

Ann Biomed Eng. 2013 Apr;41(4):837-46. doi: 10.1007/s10439-012-0721-2. Epub 2012 Dec 28.


The surprising diversity of Mycobacterium tuberculosis: change you can believe in.

Fortune SM.

J Infect Dis. 2012 Dec 1;206(11):1642-4. doi: 10.1093/infdis/jis603. Epub 2012 Sep 14. No abstract available.


Efferocytosis is an innate antibacterial mechanism.

Martin CJ, Booty MG, Rosebrock TR, Nunes-Alves C, Desjardins DM, Keren I, Fortune SM, Remold HG, Behar SM.

Cell Host Microbe. 2012 Sep 13;12(3):289-300. doi: 10.1016/j.chom.2012.06.010.


Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis.

Lee HJ, Lang PT, Fortune SM, Sassetti CM, Alber T.

Nat Struct Mol Biol. 2012 Aug;19(8):811-8. doi: 10.1038/nsmb.2318. Epub 2012 Jul 8.

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