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Results: 1 to 20 of 79

1.

Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled Bile acid receptor 1 (GP-BAR1, TGR5) agonists.

Yu DD, Sousa KM, Mattern DL, Wagner J, Fu X, Vaidehi N, Forman BM, Huang W.

Bioorg Med Chem. 2015 Apr 1;23(7):1613-28. doi: 10.1016/j.bmc.2015.01.048. Epub 2015 Feb 11.

PMID:
25735208
2.

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor.

Yu DD, Lin W, Forman BM, Chen T.

Bioorg Med Chem. 2014 Jun 1;22(11):2919-38. doi: 10.1016/j.bmc.2014.04.014. Epub 2014 Apr 16.

PMID:
24775917
3.

Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.

Yu DD, Lin W, Chen T, Forman BM.

Bioorg Med Chem. 2013 Jul 15;21(14):4266-78. doi: 10.1016/j.bmc.2013.04.069. Epub 2013 May 7.

4.

Bioimaging real-time PXR-dependent mdr1a gene regulation in mdr1a.fLUC reporter mice.

Gu L, Chen J, Synold TW, Forman BM, Kane SE.

J Pharmacol Exp Ther. 2013 Jun;345(3):438-45. doi: 10.1124/jpet.113.203562. Epub 2013 Mar 26.

5.

An improved synthesis of 6α-ethylchenodeoxycholic acid (6ECDCA), a potent and selective agonist for the Farnesoid X Receptor (FXR).

Yu D, Mattern DL, Forman BM.

Steroids. 2012 Nov;77(13):1335-8. doi: 10.1016/j.steroids.2012.09.002. Epub 2012 Sep 21.

PMID:
22999992
6.

Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis.

Chen WD, Yu D, Forman BM, Huang W, Wang YD.

Hepatology. 2013 Feb;57(2):656-66. doi: 10.1002/hep.26019. Retraction in: Hepatology. 2013 Sep;58(3):1194.

7.

Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice.

Zhang L, Wang YD, Chen WD, Wang X, Lou G, Liu N, Lin M, Forman BM, Huang W.

Hepatology. 2012 Dec;56(6):2336-43. doi: 10.1002/hep.25905.

8.

Specific bile acids inhibit hepatic fatty acid uptake in mice.

Nie B, Park HM, Kazantzis M, Lin M, Henkin A, Ng S, Song S, Chen Y, Tran H, Lai R, Her C, Maher JJ, Forman BM, Stahl A.

Hepatology. 2012 Oct;56(4):1300-10. doi: 10.1002/hep.25797.

9.

Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression.

Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, Forman BM, Xu Z, Xu R, Huang W.

Mol Endocrinol. 2012 May;26(5):775-85. doi: 10.1210/me.2011-1383. Epub 2012 Apr 2.

10.

FXR protects lung from lipopolysaccharide-induced acute injury.

Zhang L, Li T, Yu D, Forman BM, Huang W.

Mol Endocrinol. 2012 Jan;26(1):27-36. doi: 10.1210/me.2011-0042. Epub 2011 Dec 1.

12.

Insufficient bile acid signaling impairs liver repair in CYP27(-/-) mice.

Meng Z, Liu N, Fu X, Wang X, Wang YD, Chen WD, Zhang L, Forman BM, Huang W.

J Hepatol. 2011 Oct;55(4):885-95. doi: 10.1016/j.jhep.2010.12.037. Epub 2011 Feb 18.

PMID:
21334403
13.

FXR regulates liver repair after CCl4-induced toxic injury.

Meng Z, Wang Y, Wang L, Jin W, Liu N, Pan H, Liu L, Wagman L, Forman BM, Huang W.

Mol Endocrinol. 2010 May;24(5):886-97. doi: 10.1210/me.2009-0286. Epub 2010 Mar 8.

14.

Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription.

Chen WD, Wang YD, Zhang L, Shiah S, Wang M, Yang F, Yu D, Forman BM, Huang W.

Hepatology. 2010 Mar;51(3):953-62. doi: 10.1002/hep.23390.

15.

Identification of an endogenous ligand bound to a native orphan nuclear receptor.

Yuan X, Ta TC, Lin M, Evans JR, Dong Y, Bolotin E, Sherman MA, Forman BM, Sladek FM.

PLoS One. 2009;4(5):e5609. doi: 10.1371/journal.pone.0005609. Epub 2009 May 19.

16.

Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response.

Wang YD, Chen WD, Wang M, Yu D, Forman BM, Huang W.

Hepatology. 2008 Nov;48(5):1632-43. doi: 10.1002/hep.22519.

17.

Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.

Wang YD, Yang F, Chen WD, Huang X, Lai L, Forman BM, Huang W.

Mol Endocrinol. 2008 Jul;22(7):1622-32. doi: 10.1210/me.2007-0527. Epub 2008 Apr 24.

PMID:
18436567
18.

Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation.

Zhou C, Tabb MM, Nelson EL, Grün F, Verma S, Sadatrafiei A, Lin M, Mallick S, Forman BM, Thummel KE, Blumberg B.

J Clin Invest. 2006 Aug;116(8):2280-2289.

19.

Linking lipids, Alzheimer's and LXRs?

Patel NV, Forman BM.

Nucl Recept Signal. 2004;2:e001. Epub 2004 Apr 5.

20.

Detection of designer steroids.

Yuan X, Forman BM.

Nucl Recept Signal. 2005;3:e002. Epub 2005 Oct 21.

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