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The rat tyrosine phosphatase η increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue.

Le Pera I, Iuliano R, Florio T, Susini C, Trapasso F, Santoro M, Chiariotti L, Schettini G, Viglietto G, Fusco A.

Oncogene. 2016 Jul 18. doi: 10.1038/onc.2016.138. [Epub ahead of print] No abstract available.


Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells.

Corsaro A, Bajetto A, Thellung S, Begani G, Villa V, Nizzari M, Pattarozzi A, Solari A, Gatti M, Pagano A, Würth R, Daga A, Barbieri F, Florio T.

Oncotarget. 2016 May 24. doi: 10.18632/oncotarget.9575. [Epub ahead of print]


SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells.

Talarico C, Dattilo V, D'Antona L, Barone A, Amodio N, Belviso S, Musumeci F, Abbruzzese C, Bianco C, Trapasso F, Schenone S, Alcaro S, Ortuso F, Florio T, Paggi MG, Perrotti N, Amato R.

Oncotarget. 2016 Mar 29;7(13):15868-84. doi: 10.18632/oncotarget.7520.


Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA.

Vella S, Penna I, Longo L, Pioggia G, Garbati P, Florio T, Rossi F, Pagano A.

Sci Rep. 2015 Dec 17;5:18144. doi: 10.1038/srep18144.


The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.

Banelli B, Carra E, Barbieri F, Würth R, Parodi F, Pattarozzi A, Carosio R, Forlani A, Allemanni G, Marubbi D, Florio T, Daga A, Romani M.

Cell Cycle. 2015;14(21):3418-29. doi: 10.1080/15384101.2015.1090063.


Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model.

Benedetti E, Antonosante A, d'Angelo M, Cristiano L, Galzio R, Destouches D, Florio TM, Dhez AC, Astarita C, Cinque B, Fidoamore A, Rosati F, Cifone MG, Ippoliti R, Giordano A, Courty J, Cimini A.

Oncotarget. 2015 Dec 8;6(39):42091-104. doi: 10.18632/oncotarget.5990.


Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling.

Brandolini L, Cristiano L, Fidoamore A, De Pizzol M, Di Giacomo E, Florio TM, Confalone G, Galante A, Cinque B, Benedetti E, Ruffini PA, Cifone MG, Giordano A, Alecci M, Allegretti M, Cimini A.

Oncotarget. 2015 Dec 22;6(41):43375-94. doi: 10.18632/oncotarget.6234.


Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds.

Würth R, Thellung S, Bajetto A, Mazzanti M, Florio T, Barbieri F.

Drug Discov Today. 2016 Jan;21(1):190-9. doi: 10.1016/j.drudis.2015.09.017. Epub 2015 Oct 9. Review.


Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies.

Thellung S, Favoni RE, Würth R, Nizzari M, Pattarozzi A, Daga A, Florio T, Barbieri F.

Curr Drug Targets. 2016;17(7):824-49.


Mortality among a Cohort of Persons with an Intellectual Disability in New South Wales, Australia.

Florio T, Trollor J.

J Appl Res Intellect Disabil. 2015 Sep;28(5):383-93. doi: 10.1111/jar.12190. Epub 2015 May 21.


In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors.

Barbieri F, Thellung S, Ratto A, Carra E, Marini V, Fucile C, Bajetto A, Pattarozzi A, Würth R, Gatti M, Campanella C, Vito G, Mattioli F, Pagano A, Daga A, Ferrari A, Florio T.

BMC Cancer. 2015 Apr 7;15:228. doi: 10.1186/s12885-015-1235-8.


Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation.

Gentile MT, Ciniglia C, Reccia MG, Volpicelli F, Gatti M, Thellung S, Florio T, Melone MA, Colucci-D'Amato L.

PLoS One. 2015 Mar 18;10(3):e0118864. doi: 10.1371/journal.pone.0118864. eCollection 2015.


Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets.

Peretti M, Angelini M, Savalli N, Florio T, Yuspa SH, Mazzanti M.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2523-31. doi: 10.1016/j.bbamem.2014.12.012. Epub 2014 Dec 26. Review.


PPARβ/δ and γ in a rat model of Parkinson's disease: possible involvement in PD symptoms.

Falcone R, Florio TM, Di Giacomo E, Benedetti E, Cristiano L, Antonosante A, Fidoamore A, Massimi M, Alecci M, Ippoliti R, Giordano A, Cimini A.

J Cell Biochem. 2015 May;116(5):844-55. doi: 10.1002/jcb.25041.


Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.

Barbieri F, Thellung S, Würth R, Gatto F, Corsaro A, Villa V, Nizzari M, Albertelli M, Ferone D, Florio T.

Int J Endocrinol. 2014;2014:753524. doi: 10.1155/2014/753524. Epub 2014 Nov 17. Review.


Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells.

Villa V, Thellung S, Corsaro A, Novelli F, Tasso B, Colucci-D'Amato L, Gatta E, Tonelli M, Florio T.

Mol Neurobiol. 2016 Jan;53(1):57-72. doi: 10.1007/s12035-014-8982-4. Epub 2014 Nov 18.


Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current.

Gritti M, Würth R, Angelini M, Barbieri F, Peretti M, Pizzi E, Pattarozzi A, Carra E, Sirito R, Daga A, Curmi PM, Mazzanti M, Florio T.

Oncotarget. 2014 Nov 30;5(22):11252-68.


Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA.

Costa D, Gigoni A, Würth R, Cancedda R, Florio T, Pagano A.

Cancer Cell Int. 2014 Jul 2;14:59. doi: 10.1186/1475-2867-14-59. eCollection 2014.


Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures.

Mohamed A, Blanchard MP, Albertelli M, Barbieri F, Brue T, Niccoli P, Delpero JR, Monges G, Garcia S, Ferone D, Florio T, Enjalbert A, Moutardier V, Schonbrunn A, Gerard C, Barlier A, Saveanu A.

Endocr Relat Cancer. 2014 Oct;21(5):691-704. doi: 10.1530/ERC-14-0086. Epub 2014 Jul 10.


Ambulatory mental health data demonstrates the high needs of people with an intellectual disability: results from the New South Wales intellectual disability and mental health data linkage project.

Howlett S, Florio T, Xu H, Trollor J.

Aust N Z J Psychiatry. 2015 Feb;49(2):137-44. doi: 10.1177/0004867414536933. Epub 2014 Jun 9.

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