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Results: 1 to 20 of 267

1.

Inhibition of Chronic Ulcerative Colitis-associated Adenocarcinoma Development in Mice by VSL#3.

Talero E, Bolivar S, Ávila-Román J, Alcaide A, Fiorucci S, Motilva V.

Inflamm Bowel Dis. 2015 Mar 19. [Epub ahead of print]

PMID:
25793324
2.

Bile acid activated receptors are targets for regulation of integrity of gastrointestinal mucosa.

Distrutti E, Santucci L, Cipriani S, Renga B, Schiaroli E, Ricci P, Donini A, Fiorucci S.

J Gastroenterol. 2015 Feb 24. [Epub ahead of print]

PMID:
25708288
3.

Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice.

Tsuchiya H, Costa KA, Lee S, Renga B, Jaeschke H, Yang Z, Orena SJ, Goedken MJ, Zhang Y, B K, Lebofsky M, Rudraiah S, Smalling R, Guo G, Fiorucci S, Zeisel SH, Wang L.

Gastroenterology. 2015 Feb 19. pii: S0016-5085(15)00164-X. doi: 10.1053/j.gastro.2015.01.045. [Epub ahead of print]

PMID:
25701738
4.

Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists.

Renga B, Festa C, De Marino S, Di Micco S, D'Auria MV, Bifulco G, Fiorucci S, Zampella A.

Steroids. 2015 Apr;96:121-31. doi: 10.1016/j.steroids.2015.01.024. Epub 2015 Feb 7.

PMID:
25668616
5.

Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.

Festa C, Renga B, D'Amore C, Sepe V, Finamore C, De Marino S, Carino A, Cipriani S, Monti MC, Zampella A, Fiorucci S.

J Med Chem. 2014 Oct 23;57(20):8477-95. doi: 10.1021/jm501273r. Epub 2014 Oct 9.

PMID:
25247751
6.

Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP.

Distrutti E, O'Reilly JA, McDonald C, Cipriani S, Renga B, Lynch MA, Fiorucci S.

PLoS One. 2014 Sep 9;9(9):e106503. doi: 10.1371/journal.pone.0106503. eCollection 2014.

7.

Targeting FXR in cholestasis: hype or hope.

Fiorucci S, Distrutti E, Ricci P, Giuliano V, Donini A, Baldelli F.

Expert Opin Ther Targets. 2014 Dec;18(12):1449-59. doi: 10.1517/14728222.2014.956087. Epub 2014 Sep 9.

PMID:
25200104
8.

Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1).

Sepe V, Renga B, Festa C, D'Amore C, Masullo D, Cipriani S, Di Leva FS, Monti MC, Novellino E, Limongelli V, Zampella A, Fiorucci S.

J Med Chem. 2014 Sep 25;57(18):7687-701. doi: 10.1021/jm500889f. Epub 2014 Sep 7.

PMID:
25162837
9.

Computational antigenic epitope prediction by calculating electrostatic desolvation penalties of protein surfaces.

Fiorucci S, Zacharias M.

Methods Mol Biol. 2014;1184:365-74. doi: 10.1007/978-1-4939-1115-8_20.

PMID:
25048135
10.

Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation.

Sepe V, Di Leva FS, D'Amore C, Festa C, De Marino S, Renga B, D'Auria MV, Novellino E, Limongelli V, D'Souza L, Majik M, Zampella A, Fiorucci S.

Mar Drugs. 2014 May 27;12(6):3091-115. doi: 10.3390/md12063091.

11.

Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists.

Hodnik Ž, Peterlin Mašič L, Tomašić T, Smodiš D, D'Amore C, Fiorucci S, Kikelj D.

J Med Chem. 2014 Jun 12;57(11):4819-33. doi: 10.1021/jm500351m. Epub 2014 May 28.

PMID:
24828006
12.

The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2.

Renga B, Francisci D, Schiaroli E, Carino A, Cipriani S, D'Amore C, Sidoni A, Sordo RD, Ferri I, Lucattelli M, Lunghi B, Baldelli F, Fiorucci S.

PLoS One. 2014 Apr 15;9(4):e94798. doi: 10.1371/journal.pone.0094798. eCollection 2014.

13.

Phallusiasterols A and B: two new sulfated sterols from the Mediterranean tunicate Phallusia fumigata and their effects as modulators of the PXR receptor.

Imperatore C, D'Aniello F, Aiello A, Fiorucci S, D'Amore C, Sepe V, Menna M.

Mar Drugs. 2014 Apr 3;12(4):2066-78. doi: 10.3390/md12042066.

14.

First results from the LUX dark matter experiment at the Sanford underground research facility.

Akerib DS, Araújo HM, Bai X, Bailey AJ, Balajthy J, Bedikian S, Bernard E, Bernstein A, Bolozdynya A, Bradley A, Byram D, Cahn SB, Carmona-Benitez MC, Chan C, Chapman JJ, Chiller AA, Chiller C, Clark K, Coffey T, Currie A, Curioni A, Dazeley S, de Viveiros L, Dobi A, Dobson J, Dragowsky EM, Druszkiewicz E, Edwards B, Faham CH, Fiorucci S, Flores C, Gaitskell RJ, Gehman VM, Ghag C, Gibson KR, Gilchriese MG, Hall C, Hanhardt M, Hertel SA, Horn M, Huang DQ, Ihm M, Jacobsen RG, Kastens L, Kazkaz K, Knoche R, Kyre S, Lander R, Larsen NA, Lee C, Leonard DS, Lesko KT, Lindote A, Lopes MI, Lyashenko A, Malling DC, Mannino R, McKinsey DN, Mei DM, Mock J, Moongweluwan M, Morad J, Morii M, Murphy AS, Nehrkorn C, Nelson H, Neves F, Nikkel JA, Ott RA, Pangilinan M, Parker PD, Pease EK, Pech K, Phelps P, Reichhart L, Shutt T, Silva C, Skulski W, Sofka CJ, Solovov VN, Sorensen P, Stiegler T, O'Sullivan K, Sumner TJ, Svoboda R, Sweany M, Szydagis M, Taylor D, Tennyson B, Tiedt DR, Tripathi M, Uvarov S, Verbus JR, Walsh N, Webb R, White JT, White D, Witherell MS, Wlasenko M, Wolfs FL, Woods M, Zhang C; LUX Collaboration.

Phys Rev Lett. 2014 Mar 7;112(9):091303. Epub 2014 Mar 4.

PMID:
24655239
15.

Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists.

Chianese G, Sepe V, Limongelli V, Renga B, D'Amore C, Zampella A, Taglialatela-Scafati O, Fiorucci S.

Steroids. 2014 May;83:80-5. doi: 10.1016/j.steroids.2014.02.003. Epub 2014 Feb 28.

PMID:
24582706
16.

CCR5 Antagonism by Maraviroc Reduces the Potential for Gastric Cancer Cell Dissemination.

Mencarelli A, Graziosi L, Renga B, Cipriani S, D'Amore C, Francisci D, Bruno A, Baldelli F, Donini A, Fiorucci S.

Transl Oncol. 2013 Dec 1;6(6):784-93. eCollection 2013 Dec 1.

17.

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges.

Sepe V, D'Amore C, Ummarino R, Renga B, D'Auria MV, Novellino E, Sinisi A, Taglialatela-Scafati O, Nakao Y, Limongelli V, Zampella A, Fiorucci S.

Eur J Med Chem. 2014 Feb 12;73:126-34. doi: 10.1016/j.ejmech.2013.12.005. Epub 2013 Dec 15.

PMID:
24388834
18.

Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.

D'Amore C, Di Leva FS, Sepe V, Renga B, Del Gaudio C, D'Auria MV, Zampella A, Fiorucci S, Limongelli V.

J Med Chem. 2014 Feb 13;57(3):937-54. doi: 10.1021/jm401873d. Epub 2014 Jan 17.

PMID:
24387325
19.

O₂migration rates in [NiFe] hydrogenases. A joint approach combining free-energy calculations and kinetic modeling.

Topin J, Diharce J, Fiorucci S, Antonczak S, Golebiowski J.

J Phys Chem B. 2014 Jan 23;118(3):676-81. doi: 10.1021/jp4093964. Epub 2014 Jan 13.

PMID:
24377375
20.

Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis.

Mencarelli A, D'Amore C, Renga B, Cipriani S, Carino A, Sepe V, Perissutti E, D'Auria MV, Zampella A, Distrutti E, Fiorucci S.

Mar Drugs. 2013 Dec 24;12(1):36-53. doi: 10.3390/md12010036.

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