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Items: 1 to 20 of 43

1.

Differentiating the Effect of an Opioid Agonist on Cardiac Repolarization From µ-Receptor-Mediated, Indirect Effects on the QT Interval: A Randomized, 3-Way Crossover Study in Healthy Subjects.

Darpo B, Zhou M, Bai SA, Ferber G, Xiang Q, Finn A.

Clin Ther. 2015 Dec 31. pii: S0149-2918(15)01320-X. doi: 10.1016/j.clinthera.2015.12.004. [Epub ahead of print]

PMID:
26749217
2.

Reduction over time of QTc prolongation in patients with sotalol after cardioversion of atrial fibrillation.

Lenhoff H, Darpö B, Ferber G, Rosenqvist M, Frick M.

Heart Rhythm. 2015 Dec 3. pii: S1547-5271(15)01513-1. doi: 10.1016/j.hrthm.2015.11.040. [Epub ahead of print]

PMID:
26654918
3.

The Power of Phase I Studies to Detect Clinical Relevant QTc Prolongation: A Resampling Simulation Study.

Ferber G, Lorch U, Täubel J.

Biomed Res Int. 2015;2015:293564. doi: 10.1155/2015/293564. Epub 2015 Oct 5.

5.

Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria.

Darpo B, Ferber G, Siegl P, Laurijssens B, Macintyre F, Toovey S, Duparc S.

Br J Clin Pharmacol. 2015 Oct;80(4):706-15. doi: 10.1111/bcp.12680. Epub 2015 Jul 14.

PMID:
25966781
6.

Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase.

Darpo B, Benson C, Dota C, Ferber G, Garnett C, Green CL, Jarugula V, Johannesen L, Keirns J, Krudys K, Liu J, Ortemann-Renon C, Riley S, Sarapa N, Smith B, Stoltz RR, Zhou M, Stockbridge N.

Clin Pharmacol Ther. 2015 Apr;97(4):326-35. doi: 10.1002/cpt.60.

PMID:
25670536
7.

The reproducibility of QTc changes after meal intake.

Taubel J, Ferber G.

J Electrocardiol. 2015 Mar-Apr;48(2):274-5. doi: 10.1016/j.jelectrocard.2014.11.006. Epub 2014 Nov 15. No abstract available.

8.

Detection of QTc effects in small studies--implications for replacing the thorough QT study.

Ferber G, Zhou M, Darpo B.

Ann Noninvasive Electrocardiol. 2015 Jul;20(4):368-77. doi: 10.1111/anec.12227. Epub 2014 Nov 4.

PMID:
25367715
9.

Concentration-effect modeling based on change from baseline to assess the prolonging effect of drugs on QTc together with an estimate of the circadian time course.

Ferber G, Wang D, Täubel J.

J Clin Pharmacol. 2014 Dec;54(12):1400-6. doi: 10.1002/jcph.347. Epub 2014 Jun 27.

PMID:
24935561
10.

Analyzing the relationship of QT interval and exposure to nitazoxanide, a prospective candidate for influenza antiviral therapy--A formal TQT study.

Täubel J, Lorch U, Rossignol JF, Ferber G, Camm AJ.

J Clin Pharmacol. 2014 Sep;54(9):987-94. doi: 10.1002/jcph.300. Epub 2014 Apr 15.

PMID:
24691901
11.

Importance of subject-specific QT/RR curvatures in the design of individual heart rate corrections of the QT interval.

Ferber G, Zhou M M, Darpo B.

J Electrocardiol. 2014 May-Jun;47(3):385-6. doi: 10.1016/j.jelectrocard.2013.12.010. Epub 2013 Dec 28. No abstract available.

PMID:
24468293
12.

The IQ-CSRC prospective clinical Phase 1 study: "Can early QT assessment using exposure response analysis replace the thorough QT study?".

Darpo B, Sarapa N, Garnett C, Benson C, Dota C, Ferber G, Jarugula V, Johannesen L, Keirns J, Krudys K, Ortemann-Renon C, Riley S, Rogers-Subramaniam D, Stockbridge N.

Ann Noninvasive Electrocardiol. 2014 Jan;19(1):70-81. doi: 10.1111/anec.12128. Epub 2013 Dec 30. Review.

PMID:
24372708
13.

Lomitapide at supratherapeutic plasma levels does not prolong the Qtc interval--results from a TQT study with moxifloxacin and ketoconazole.

Darpo B, Ferber G, Zhou M, Sumeray M, Sager P.

Ann Noninvasive Electrocardiol. 2013 Nov;18(6):577-89. doi: 10.1111/anec.12103. Epub 2013 Sep 30.

PMID:
24118671
14.

Thorough QT study of the effect of oral moxifloxacin on QTc interval in the fed and fasted state in healthy Japanese and Caucasian subjects.

Taubel J, Ferber G, Lorch U, Batchvarov V, Savelieva I, Camm AJ.

Br J Clin Pharmacol. 2014 Jan;77(1):170-9. doi: 10.1111/bcp.12168.

15.

Preclinical QT safety assessment: cross-species comparisons and human translation from an industry consortium.

Holzgrefe H, Ferber G, Champeroux P, Gill M, Honda M, Greiter-Wilke A, Baird T, Meyer O, Saulnier M.

J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):61-101. doi: 10.1016/j.vascn.2013.05.004. Epub 2013 May 17.

16.

Assessment of the cardiac safety and pharmacokinetics of a short course, twice daily dose of orally-administered mifepristone in healthy male subjects.

Darpo B, Bullingham R, Combs DL, Ferber G, Hafez K.

Cardiol J. 2013;20(2):152-60. doi: 10.5603/CJ.2013.0028.

17.

Pattern recognition analysis of digital ECGs: decreased QT measurement error and improved precision compared to semi-automated methods.

Meyer O, Ferber G, Greig G, Holzgrefe HH.

J Electrocardiol. 2013 Mar-Apr;46(2):118-25. doi: 10.1016/j.jelectrocard.2012.11.012. Epub 2012 Dec 22.

PMID:
23266069
18.

Insulin at normal physiological levels does not prolong QT(c) interval in thorough QT studies performed in healthy volunteers.

Taubel J, Lorch U, Ferber G, Singh J, Batchvarov VN, Savelieva I, Camm AJ.

Br J Clin Pharmacol. 2013 Feb;75(2):392-403. doi: 10.1111/j.1365-2125.2012.04376.x.

20.

Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects (pages.

Sugiyama A, Nakamura Y, Nishimura S, Adachi-Akahane S, Kumagai Y, Gayed J, Naseem A, Ferber G, Taubel J, Camm J.

Br J Clin Pharmacol. 2012 Mar;73(3):455-9.

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