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A miR-1207-5p binding site polymorphism abolishes regulation of HBEGF and is associated with disease severity in CFHR5 nephropathy.

Papagregoriou G, Erguler K, Dweep H, Voskarides K, Koupepidou P, Athanasiou Y, Pierides A, Gretz N, Felekkis KN, Deltas C.

PLoS One. 2012;7(2):e31021. doi: 10.1371/journal.pone.0031021. Epub 2012 Feb 2.


Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways.

Koupepidou P, Felekkis KN, Kränzlin B, Sticht C, Gretz N, Deltas C.

BMC Nephrol. 2010 Sep 2;11:23. doi: 10.1186/1471-2369-11-23. Erratum in: BMC Nephrol. 2011;12:6.


Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.

Felekkis KN, Koupepidou P, Kastanos E, Witzgall R, Bai CX, Li L, Tsiokas L, Gretz N, Deltas C.

BMC Nephrol. 2008 Aug 25;9:10. doi: 10.1186/1471-2369-9-10.


AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner.

Felekkis KN, Narsimhan RP, Near R, Castro AF, Zheng Y, Quilliam LA, Lerner A.

Mol Cancer Res. 2005 Jan;3(1):32-41.


AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter.

Cai D, Iyer A, Felekkis KN, Near RI, Luo Z, Chernoff J, Albanese C, Pestell RG, Lerner A.

Cancer Res. 2003 Oct 15;63(20):6802-8.


The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42.

Cai D, Felekkis KN, Near RI, O'Neill GM, van Seventer JM, Golemis EA, Lerner A.

J Immunol. 2003 Jan 15;170(2):969-78.

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