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Results: 1 to 20 of 49

1.

Systems pharmacology models can be used to understand complex pharmacokinetic-pharmacodynamic behavior: an example using 5-lipoxygenase inhibitors.

Demin O, Karelina T, Svetlichniy D, Metelkin E, Speshilov G, Demin O Jr, Fairman D, van der Graaf PH, Agoram BM.

CPT Pharmacometrics Syst Pharmacol. 2013 Sep 11;2:e74. doi: 10.1038/psp.2013.49.

2.

Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach.

Karelina TA, Zhudenkov KV, Demin OO, Svetlichny DV, Agoram B, Fairman D, Demin OV.

BMC Syst Biol. 2012 Nov 12;6:141. doi: 10.1186/1752-0509-6-141.

3.

Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling.

Kojonazarov B, Sydykov A, Pullamsetti SS, Luitel H, Dahal BK, Kosanovic D, Tian X, Majewski M, Baumann C, Evans S, Phillips P, Fairman D, Davie N, Wayman C, Kilty I, Weissmann N, Grimminger F, Seeger W, Ghofrani HA, Schermuly RT.

Int J Cardiol. 2013 Sep 10;167(6):2630-7. doi: 10.1016/j.ijcard.2012.06.129. Epub 2012 Jul 31.

PMID:
22854298
4.

Acidic triazoles as soluble guanylate cyclase stimulators.

Roberts LR, Bradley PA, Bunnage ME, England KS, Fairman D, Fobian YM, Fox DN, Gymer GE, Heasley SE, Molette J, Smith GL, Schmidt MA, Tones MA, Dack KN.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6515-8. doi: 10.1016/j.bmcl.2011.08.071. Epub 2011 Aug 28.

PMID:
21924901
5.

A hidden Markov model to assess drug-induced sleep fragmentation in the telemetered rat.

Diack C, Ackaert O, Ploeger BA, van der Graaf PH, Gurrell R, Ivarsson M, Fairman D.

J Pharmacokinet Pharmacodyn. 2011 Dec;38(6):697-711. doi: 10.1007/s10928-011-9215-3. Epub 2011 Sep 10.

6.

Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.

Millan DS, Bunnage ME, Burrows JL, Butcher KJ, Dodd PG, Evans TJ, Fairman DA, Hughes SJ, Kilty IC, Lemaitre A, Lewthwaite RA, Mahnke A, Mathias JP, Philip J, Smith RT, Stefaniak MH, Yeadon M, Phillips C.

J Med Chem. 2011 Nov 24;54(22):7797-814. doi: 10.1021/jm200677b. Epub 2011 Oct 28.

PMID:
21888439
7.

Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.

Glossop PA, Watson CA, Price DA, Bunnage ME, Middleton DS, Wood A, James K, Roberts D, Strang RS, Yeadon M, Perros-Huguet C, Clarke NP, Trevethick MA, Machin I, Stuart EF, Evans SM, Harrison AC, Fairman DA, Agoram B, Burrows JL, Feeder N, Fulton CK, Dillon BR, Entwistle DA, Spence FJ.

J Med Chem. 2011 Oct 13;54(19):6888-904. doi: 10.1021/jm200884j. Epub 2011 Sep 20.

PMID:
21870878
8.

Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD.

Jones LH, Baldock H, Bunnage ME, Burrows J, Clarke N, Coghlan M, Entwistle D, Fairman D, Feeder N, Fulton C, Hilton L, James K, Jones RM, Kenyon AS, Marshall S, Newman SD, Osborne R, Patel S, Selby MD, Stuart EF, Trevethick MA, Wright KN, Price DA.

Bioorg Med Chem Lett. 2011 May 1;21(9):2759-63. doi: 10.1016/j.bmcl.2010.10.132. Epub 2010 Oct 31.

PMID:
21075627
9.

Small, non-peptide C5a receptor antagonists: part 1.

Blagg J, Mowbray C, Pryde DC, Salmon G, Schmid E, Fairman D, Beaumont K.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5601-4. doi: 10.1016/j.bmcl.2008.08.106. Epub 2008 Aug 31.

PMID:
18809326
10.

Small, non-peptide C5a receptor antagonists: part 2.

Blagg J, Mowbray C, Pryde D, Salmon G, Fairman D, Schmid E, Beaumont K.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5605-8. doi: 10.1016/j.bmcl.2008.08.101. Epub 2008 Aug 31.

PMID:
18804369
11.

Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?

Fairman DA, Collins C, Chapple S.

Drug Metab Dispos. 2007 Dec;35(12):2159-65. Epub 2007 Sep 6.

12.
13.

Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures.

Cho S, Liu D, Fairman D, Li P, Jenkins L, McGonigle P, Wood A.

Neurochem Int. 2004 Jul;45(1):117-27.

PMID:
15082229
14.

Functional validation of adult hippocampal organotypic cultures as an in vitro model of brain injury.

Finley M, Fairman D, Liu D, Li P, Wood A, Cho S.

Brain Res. 2004 Mar 19;1001(1-2):125-32.

PMID:
14972661
15.

The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

MacInnes A, Fairman DA, Binding P, Rhodes Ja, Wyatt MJ, Phelan A, Haddock PS, Karran EH.

Circ Res. 2003 Aug 8;93(3):e26-32. Epub 2003 Jul 17.

17.
18.

New method for stereotactic hypophysectomy with radiological visualization of lesion size.

Fairman D, Lavallol MA.

Confin Neurol. 1975;37(1-3):172-6. No abstract available.

PMID:
1093782
19.

Thalamic tractotomy for the alleviation of intractable pain in cancer.

Fairman D, Llavallol MA.

Cancer. 1973 Mar;31(3):700-7. No abstract available.

PMID:
4120928
20.

Stereotactic hypothalamotomy for the alleviation of pain in malignant tumors.

Fairman D.

J Surg Oncol. 1973;5(2):79-84. No abstract available.

PMID:
4574196
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