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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 2
1996 3
1997 4
1998 6
1999 5
2000 10
2001 10
2002 15
2003 17
2004 10
2005 11
2006 12
2007 17
2008 10
2009 8
2010 14
2011 10
2012 4
2013 6
2014 3
2015 3
2016 4
2017 5
2018 5
2019 2
2020 3
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2024 2

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191 results

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Page 1
FTI-277 and GGTI-289 induce apoptosis via inhibition of the Ras/ERK and Ras/mTOR pathway in head and neck carcinoma HEp-2 and HSC-3 cells.
Tateishi K, Tsubaki M, Takeda T, Yamatomo Y, Imano M, Satou T, Nishida S. Tateishi K, et al. J BUON. 2021 Mar-Apr;26(2):606-612. J BUON. 2021. PMID: 34077012 Free article.
FTI-277 and GGTI-287 induced apoptosis in HSC-3 cells at much lower concentrations than that in HEp-2 cells. FTI-277 and GGTI-287 decreased the concentration of phosphorylated ERK1/2 and mTOR via membrane localization of Ras and enhanced Bim expression …
FTI-277 and GGTI-287 induced apoptosis in HSC-3 cells at much lower concentrations than that in HEp-2 cells. FTI-277 …
FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis.
Ponnusamy A, Sinha S, Hyde GD, Borland SJ, Taylor RF, Pond E, Eyre HJ, Inkson CA, Gilmore A, Ashton N, Kalra PA, Canfield AE. Ponnusamy A, et al. PLoS One. 2018 Apr 24;13(4):e0196232. doi: 10.1371/journal.pone.0196232. eCollection 2018. PLoS One. 2018. PMID: 29689070 Free PMC article.
FTI-277 increases Akt signaling in VSMC in short-term serum-stimulation assays and in long-term mineralization assays. In contrast, manumycin A has no effect on Akt signaling or mineralization. Co-incubation of VSMC with FTI-277 and SH6 (an Akt inhibit …
FTI-277 increases Akt signaling in VSMC in short-term serum-stimulation assays and in long-term mineralization assays. In cont …
Farnesyl transferase inhibitor FTI-277 inhibits breast cell invasion and migration by blocking H-Ras activation.
Lee KH, Koh M, Moon A. Lee KH, et al. Oncol Lett. 2016 Sep;12(3):2222-2226. doi: 10.3892/ol.2016.4837. Epub 2016 Jul 11. Oncol Lett. 2016. PMID: 27602167 Free PMC article.
The invasive/migratory phenotypes of the H-Ras-MCF10A and Hs578T cells were effectively inhibited by FTI-277 treatment. By contrast, FTI-277 did not affect the invasive/migratory phenotypes of MDA-MB-231 cells. However, the EGF-induced invasion of MDA- …
The invasive/migratory phenotypes of the H-Ras-MCF10A and Hs578T cells were effectively inhibited by FTI-277 treatment. By con …
Alendronate and FTI-277 combination as a possible therapeutic approach for hepatocellular carcinoma: An in vitro study.
Ilyas A, Hashim Z, Channa IS, Zarina S. Ilyas A, et al. Hepatobiliary Pancreat Dis Int. 2018 Jun;17(3):241-250. doi: 10.1016/j.hbpd.2018.03.013. Epub 2018 Mar 24. Hepatobiliary Pancreat Dis Int. 2018. PMID: 29627155
RESULTS: Treatment of hepatocellular carcinoma (HCC) cell line with FTI-277 alone showed cell death in a time and dose dependent manner while in combination with alendronate, a synergistic apoptotic effect at 24 h was observed. Proteomic studies on the 20 mol/L F …
RESULTS: Treatment of hepatocellular carcinoma (HCC) cell line with FTI-277 alone showed cell death in a time and dose depende …
Farnesyltransferase inhibitor FTI-277 inhibits PD-L1 expression on septic spleen lymphocytes and promotes spleen lymphocyte activation.
Li W, Tu J, Liu X, Yang W. Li W, et al. Clin Exp Immunol. 2017 Oct;190(1):8-18. doi: 10.1111/cei.12995. Epub 2017 Jul 14. Clin Exp Immunol. 2017. PMID: 28556912 Free PMC article.
In this study, mice with CLP-induced sepsis were treated with farnesyltransferase inhibitor (FTI-277), and PD-L1 expression on septic spleen lymphocytes was examined. ...Furthermore, FTI-277 reduced spleen lymphocyte apoptosis in septic mice. Therefore …
In this study, mice with CLP-induced sepsis were treated with farnesyltransferase inhibitor (FTI-277), and PD-L1 expression on …
Long-term treatment of farnesyltransferase inhibitor FTI-277 induces neurotoxicity of hippocampal neurons from rat embryo in a ROS-dependent manner.
Kim DM, Ryu SW, Choi C. Kim DM, et al. Biochem Biophys Res Commun. 2010 Dec 3;403(1):91-6. doi: 10.1016/j.bbrc.2010.10.123. Epub 2010 Oct 30. Biochem Biophys Res Commun. 2010. PMID: 21040708
Here, we report the neurotoxic effects of FTI-277 and the involvement of reactive oxygen species (ROS) in FTI-induced neurotoxicity. ...Moreover, treatment with FTI-277 dramatically increased intracellular levels of ROS, which was sustained for 4 days; …
Here, we report the neurotoxic effects of FTI-277 and the involvement of reactive oxygen species (ROS) in FTI-induced neurotox …
Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
Yang W, Yamada M, Tamura Y, Chang K, Mao J, Zou L, Feng Y, Kida K, Scherrer-Crosbie M, Chao W, Ichinose F, Yu YM, Fischman AJ, Tompkins RG, Yao S, Kaneki M. Yang W, et al. J Pharmacol Exp Ther. 2011 Dec;339(3):832-41. doi: 10.1124/jpet.111.183558. Epub 2011 Aug 26. J Pharmacol Exp Ther. 2011. PMID: 21873557 Free PMC article.
FTI-277 reverted to or mitigated sepsis-induced apoptosis in spleen and thymus, increased splenic CD4(+)Foxp3(+) Tregs, and suppressed IFN-gamma secretion and proliferation of splenocytes in response to anti-CD3+CD28 antibodies in mice. Moreover, FTI-277 …
FTI-277 reverted to or mitigated sepsis-induced apoptosis in spleen and thymus, increased splenic CD4(+)Foxp3(+) Tregs, and su …
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM. Lerner EC, et al. J Biol Chem. 1995 Nov 10;270(45):26802-6. doi: 10.1074/jbc.270.45.26802. J Biol Chem. 1995. PMID: 7592920 Free article.
FTI-277 induced accumulation of cytoplasmic non-farnesylated H-Ras that was able to bind Raf and form cytoplasmic Ras/Raf complexes in which Raf kinase was not activated. Furthermore, FTI-277 blocked constitutive activation of mitogen-activated protein …
FTI-277 induced accumulation of cytoplasmic non-farnesylated H-Ras that was able to bind Raf and form cytoplasmic Ras/Raf comp …
Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis.
Nam JS, Ino Y, Sakamoto M, Hirohashi S. Nam JS, et al. Jpn J Cancer Res. 2002 Sep;93(9):1020-8. doi: 10.1111/j.1349-7006.2002.tb02479.x. Jpn J Cancer Res. 2002. PMID: 12359056 Free PMC article.
In cell aggregation assays, FTI-277 stimulated aggregation of colon, liver and breast cancer cells. In vitro cultures of cancer cells showed that FTI-277 induced strong cell-cell contact. Immunoblotting analysis showed that FTI-277 increa …
In cell aggregation assays, FTI-277 stimulated aggregation of colon, liver and breast cancer cells. In vitro cultures of cance …
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.
Bolick SC, Landowski TH, Boulware D, Oshiro MM, Ohkanda J, Hamilton AD, Sebti SM, Dalton WS. Bolick SC, et al. Leukemia. 2003 Feb;17(2):451-7. doi: 10.1038/sj.leu.2402832. Leukemia. 2003. PMID: 12592346
A combination of FTI-277 and a geranylgeranyltransferase I inhibitor (GGTI)-2166 inhibited K-Ras processing and enhanced cell death in 8226 cells. U266 cells and Bcl-x(L) transfectants were equally sensitive to FTI-277 treatment. Similarly, 8226 cells …
A combination of FTI-277 and a geranylgeranyltransferase I inhibitor (GGTI)-2166 inhibited K-Ras processing and enhanced cell …
191 results