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Showing results for f box
Your search for F-bolt retrieved no results
The Biology of F-box Proteins: The SCF Family of E3 Ubiquitin Ligases.
Nguyen KM, Busino L. Nguyen KM, et al. Adv Exp Med Biol. 2020;1217:111-122. doi: 10.1007/978-981-15-1025-0_8. Adv Exp Med Biol. 2020. PMID: 31898225 Review.
F-box proteins function as substrate adaptors for the S-phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes, which mediate the proteasomal degradation of a diverse range of regulatory proteins. 20 yea …
F-box proteins function as substrate adaptors for the S-phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-b …
F-Box Proteins and Cancer.
Yumimoto K, Yamauchi Y, Nakayama KI. Yumimoto K, et al. Cancers (Basel). 2020 May 15;12(5):1249. doi: 10.3390/cancers12051249. Cancers (Basel). 2020. PMID: 32429232 Free PMC article. Review.
Here, we summarize the roles of specific F-box proteins that have been shown to function as tumor promoters or suppressors. We also highlight proto-oncoproteins that are targeted for ubiquitylation by multiple F-box proteins, and discuss how these F …
Here, we summarize the roles of specific F-box proteins that have been shown to function as tumor promoters or suppressors. We …
F-box only protein 9 and its role in cancer.
Hussain S, Dong J, Ma X, Li J, Chen S, Clement A, Liu H. Hussain S, et al. Mol Biol Rep. 2022 Feb;49(2):1537-1544. doi: 10.1007/s11033-021-07057-7. Epub 2022 Jan 13. Mol Biol Rep. 2022. PMID: 35025031 Review.
Disorders of F-box protein-mediated proteolysis lead to human malignancies. ...Targeting F-box protein or F-box protein signaling pathways could be an effective strategy for preventing or treating human cancer. ...
Disorders of F-box protein-mediated proteolysis lead to human malignancies. ...Targeting F-box protein or F …
Inhibitors Targeting the F-BOX Proteins.
Naseem Y, Zhang C, Zhou X, Dong J, Xie J, Zhang H, Agboyibor C, Bi Y, Liu H. Naseem Y, et al. Cell Biochem Biophys. 2023 Dec;81(4):577-597. doi: 10.1007/s12013-023-01160-1. Epub 2023 Aug 25. Cell Biochem Biophys. 2023. PMID: 37624574 Review.
Any significant mutation in F-box protein-mediated proteolysis can cause human malformations. ...To target F-box proteins and their associated signaling pathways for cancer treatment, researchers have developed thousands of F-box inhibito …
Any significant mutation in F-box protein-mediated proteolysis can cause human malformations. ...To target F-box …
Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis.
Harper JW, Schulman BA. Harper JW, et al. Annu Rev Biochem. 2021 Jun 20;90:403-429. doi: 10.1146/annurev-biochem-090120-013613. Epub 2021 Apr 6. Annu Rev Biochem. 2021. PMID: 33823649 Free PMC article. Review.
Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad biological processes through target-specific ubiquitylation. Our knowledge of this system emerged from the F-box hypothesis, posited a quarter century ago: Numerous interchangeab …
Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad biological processes through target-specific ubiquit …
Role of F-box E3-ubiquitin ligases in plant development and stress responses.
Saxena H, Negi H, Sharma B. Saxena H, et al. Plant Cell Rep. 2023 Jul;42(7):1133-1146. doi: 10.1007/s00299-023-03023-8. Epub 2023 May 17. Plant Cell Rep. 2023. PMID: 37195503 Review.
F-box E3-ubiquitin ligases regulate critical biological processes in plant development and stress responses. ...The diverse and most prominent protein family among eukaryotes, F-box proteins, are a vital component of the multi-subunit SCF (Skp1-Cullin …
F-box E3-ubiquitin ligases regulate critical biological processes in plant development and stress responses. ...The diverse an …
F-box proteins involved in cancer-associated drug resistance.
Gong J, Zhou Y, Liu D, Huo J. Gong J, et al. Oncol Lett. 2018 Jun;15(6):8891-8900. doi: 10.3892/ol.2018.8500. Epub 2018 Apr 16. Oncol Lett. 2018. PMID: 29805625 Free PMC article. Review.
As F-box proteins have the ability to control the degradation of several crucial protein targets associated with drug resistance, the dysregulation of these proteins may lead to induction of chemoresistance in cancer cells. ...The present review serves to provide a …
As F-box proteins have the ability to control the degradation of several crucial protein targets associated with drug resistan …
F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects.
Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X, Piao HL, Liu H. Tekcham DS, et al. Theranostics. 2020 Mar 4;10(9):4150-4167. doi: 10.7150/thno.42735. eCollection 2020. Theranostics. 2020. PMID: 32226545 Free PMC article. Review.
According to the specific domains, F-box proteins are further classified into three sub-families: 1) F-box with leucine rich amino acid repeats (FBXL); 2) F-box with WD 40 amino acid repeats (FBXW); 3) F-box only with unchar …
According to the specific domains, F-box proteins are further classified into three sub-families: 1) F-box with …
F-box proteins in epigenetic regulation of cancer.
Shen J, Spruck C. Shen J, et al. Oncotarget. 2017 Nov 16;8(66):110650-110655. doi: 10.18632/oncotarget.22469. eCollection 2017 Dec 15. Oncotarget. 2017. PMID: 29299176 Free PMC article. Review.
Recent advancements in the cancer epigenetics field have identified extensive alterations of the epigenetic network in human cancers, including histone modifications and DNA methylation. F-box proteins, the substrate receptors of SCF (SKP1-Cullin1-F-box …
Recent advancements in the cancer epigenetics field have identified extensive alterations of the epigenetic network in human cancers, includ …
F-box proteins everywhere.
Lechner E, Achard P, Vansiri A, Potuschak T, Genschik P. Lechner E, et al. Curr Opin Plant Biol. 2006 Dec;9(6):631-8. doi: 10.1016/j.pbi.2006.09.003. Epub 2006 Sep 26. Curr Opin Plant Biol. 2006. PMID: 17005440 Review.
Among the E3 families, the SCF is the best understood; it consists of a multi-protein complex in which the F-box protein plays a crucial role by recruiting the target substrate. Strikingly, nearly 700 F-box proteins have been predicted in Arabidopsis, …
Among the E3 families, the SCF is the best understood; it consists of a multi-protein complex in which the F-box protein plays …
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