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Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect.

Senthilkumar R, Karaman DŞ, Paul P, Björk EM, Odén M, Eriksson JE, Rosenholm JM.

Biomater Sci. 2015 Jan 2;3(1):103-11. doi: 10.1039/c4bm00278d. Epub 2014 Sep 8.


Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells.

Niemelä E, Desai D, Nkizinkiko Y, Eriksson JE, Rosenholm JM.

Eur J Pharm Biopharm. 2015 Jul 14. pii: S0939-6411(15)00298-2. doi: 10.1016/j.ejpb.2015.07.009. [Epub ahead of print]


Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers.

Jiu Y, Lehtimäki J, Tojkander S, Cheng F, Jäälinoja H, Liu X, Varjosalo M, Eriksson JE, Lappalainen P.

Cell Rep. 2015 Jun 16;11(10):1511-8. doi: 10.1016/j.celrep.2015.05.008. Epub 2015 May 28.


Sphingolipids inhibit vimentin-dependent cell migration.

Hyder CL, Kemppainen K, Isoniemi KO, Imanishi SY, Goto H, Inagaki M, Fazeli E, Eriksson JE, Törnquist K.

J Cell Sci. 2015 Jun 1;128(11):2057-69. doi: 10.1242/jcs.160341. Epub 2015 Apr 23.


Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells.

Lindqvist J, Imanishi SY, Torvaldson E, Malinen M, Remes M, Örn F, Palvimo JJ, Eriksson JE.

Mol Biol Cell. 2015 Jun 1;26(11):1971-84. doi: 10.1091/mbc.E14-12-1634. Epub 2015 Apr 7.


Phosphorylation of lamins determine their structural properties and signaling functions.

Torvaldson E, Kochin V, Eriksson JE.

Nucleus. 2015 May 4;6(3):166-71. doi: 10.1080/19491034.2015.1017167. Epub 2015 Mar 20.


Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover.

Seltmann K, Cheng F, Wiche G, Eriksson JE, Magin TM.

J Invest Dermatol. 2015 Jun;135(6):1609-20. doi: 10.1038/jid.2015.46. Epub 2015 Feb 10.


Interphase phosphorylation of lamin A.

Kochin V, Shimi T, Torvaldson E, Adam SA, Goldman A, Pack CG, Melo-Cardenas J, Imanishi SY, Goldman RD, Eriksson JE.

J Cell Sci. 2014 Jun 15;127(Pt 12):2683-96. doi: 10.1242/jcs.141820. Epub 2014 Apr 16.


PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner.

Sjöqvist M, Antfolk D, Ferraris S, Rraklli V, Haga C, Antila C, Mutvei A, Imanishi SY, Holmberg J, Jin S, Eriksson JE, Lendahl U, Sahlgren C.

Cell Res. 2014 Apr;24(4):433-50. doi: 10.1038/cr.2014.34. Epub 2014 Mar 25.


Nestin regulates prostate cancer cell invasion by influencing the localisation and functions of FAK and integrins.

Hyder CL, Lazaro G, Pylvänäinen JW, Roberts MW, Qvarnström SM, Eriksson JE.

J Cell Sci. 2014 May 15;127(Pt 10):2161-73. doi: 10.1242/jcs.125062. Epub 2014 Mar 7.


Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells.

Paul P, Rajendran SK, Peuhu E, Alshatwi AA, Akbarsha MA, Hietanen S, Eriksson JE.

Biochem Pharmacol. 2014 May 15;89(2):171-84. doi: 10.1016/j.bcp.2014.02.011. Epub 2014 Feb 22.


Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.

de Thonel A, Hazoumé A, Kochin V, Isoniemi K, Jego G, Fourmaux E, Hammann A, Mjahed H, Filhol O, Micheau O, Rocchi P, Mezger V, Eriksson JE, Rangnekar VM, Garrido C.

Cell Death Dis. 2014 Jan 23;5:e1016. doi: 10.1038/cddis.2013.532.


The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.

Koenig A, Buskiewicz IA, Fortner KA, Russell JQ, Asaoka T, He YW, Hakem R, Eriksson JE, Budd RC.

J Biol Chem. 2014 Jan 10;289(2):1183-91. doi: 10.1074/jbc.M113.506428. Epub 2013 Nov 25.


The antitumor lignan Nortrachelogenin sensitizes prostate cancer cells to TRAIL-induced cell death by inhibition of the Akt pathway and growth factor signaling.

Peuhu E, Paul P, Remes M, Holmbom T, Eklund P, Sjöholm R, Eriksson JE.

Biochem Pharmacol. 2013 Sep 1;86(5):571-83. doi: 10.1016/j.bcp.2013.05.026. Epub 2013 Jun 6.


Nucleolar AATF regulates c-Jun-mediated apoptosis.

Ferraris SE, Isoniemi K, Torvaldson E, Anckar J, Westermarck J, Eriksson JE.

Mol Biol Cell. 2012 Nov;23(21):4323-32. doi: 10.1091/mbc.E12-05-0419. Epub 2012 Aug 29.


Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization.

Karaman DS, Desai D, Senthilkumar R, Johansson EM, Råtts N, Odén M, Eriksson JE, Sahlgren C, Toivola DM, Rosenholm JM.

Nanoscale Res Lett. 2012 Jul 1;7(1):358. doi: 10.1186/1556-276X-7-358.


Quantitative analysis of the self-assembly strategies of intermediate filaments from tetrameric vimentin.

Czeizler E, Mizera A, Czeizler E, Back RJ, Eriksson JE, Petre I.

IEEE/ACM Trans Comput Biol Bioinform. 2012 May-Jun;9(3):885-98. doi: 10.1109/TCBB.2011.154.


Nestin is not essential for development of the CNS but required for dispersion of acetylcholine receptor clusters at the area of neuromuscular junctions.

Mohseni P, Sung HK, Murphy AJ, Laliberte CL, Pallari HM, Henkelman M, Georgiou J, Xie G, Quaggin SE, Thorner PS, Eriksson JE, Nagy A.

J Neurosci. 2011 Aug 10;31(32):11547-52. doi: 10.1523/JNEUROSCI.4396-10.2011.


Insights into intermediate filament regulation from development to ageing.

Hyder CL, Isoniemi KO, Torvaldson ES, Eriksson JE.

J Cell Sci. 2011 May 1;124(Pt 9):1363-72. doi: 10.1242/jcs.041244.


Nestin as a regulator of Cdk5 in differentiating myoblasts.

Pallari HM, Lindqvist J, Torvaldson E, Ferraris SE, He T, Sahlgren C, Eriksson JE.

Mol Biol Cell. 2011 May;22(9):1539-49. doi: 10.1091/mbc.E10-07-0568. Epub 2011 Feb 23.

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