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Results: 1 to 20 of 272

1.

Nova1 is a master regulator of alternative splicing in pancreatic beta cells.

Villate O, Turatsinze JV, Mascali LG, Grieco FA, Nogueira TC, Cunha DA, Nardelli TR, Sammeth M, Salunkhe VA, Esguerra JL, Eliasson L, Marselli L, Marchetti P, Eizirik DL.

Nucleic Acids Res. 2015;42(18):11818-30. doi: 10.1093/nar/gku861. Epub 2014 Sep 23.

PMID:
25249621
[PubMed - in process]
Free Article
2.

Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes.

Rondas D, Crèvecoeur I, D'Hertog W, Ferreira GB, Staes A, Garg AD, Eizirik DL, Agostinis P, Gevaert K, Overbergh L, Mathieu C.

Diabetes. 2014 Sep 9. pii: DB_140621. [Epub ahead of print]

PMID:
25204978
[PubMed - as supplied by publisher]
3.

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.

Fløyel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M, Overgaard AJ, Berchtold LA, Wiberg A, Poulsen P, Hansen L, Rosinger S, Boehm BO, Ram R, Nguyen Q, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH, Reinheckel T, von Herrath M, Vaag A, Eizirik DL, Mortensen HB, Størling J, Pociot F.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10. doi: 10.1073/pnas.1402571111. Epub 2014 Jun 30.

PMID:
24982147
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

[Chronicle of a death foretold: endoplasmic reticulum stress and beta cell apoptosis in diabetes].

Eizirik DL, Millard I.

Med Sci (Paris). 2014 May;30(5):496-9. doi: 10.1051/medsci/20143005007. Epub 2014 Jun 13. French. No abstract available.

PMID:
24939531
[PubMed - indexed for MEDLINE]
5.

A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.

Brozzi F, Gerlo S, Grieco FA, Nardelli TR, Lievens S, Gysemans C, Marselli L, Marchetti P, Mathieu C, Tavernier J, Eizirik DL.

J Biol Chem. 2014 Jul 25;289(30):20677-93.

PMID:
24936061
[PubMed - in process]
6.

MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis.

Zhong J, Yu Q, Yang P, Rao X, He L, Fang J, Tu Y, Zhang Z, Lai Q, Zhang S, Kuczma M, Kraj P, Xu JF, Gong F, Zhou J, Wen L, Eizirik DL, Du J, Wang W, Wang CY.

J Autoimmun. 2014 Sep;53:95-104. doi: 10.1016/j.jaut.2014.05.006. Epub 2014 Jun 14.

PMID:
24934598
[PubMed - in process]
7.

JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.

Cunha DA, Gurzov EN, Naamane N, Ortis F, Cardozo AK, Bugliani M, Marchetti P, Eizirik DL, Cnop M.

Cell Death Differ. 2014 Aug;21(8):1313-24. doi: 10.1038/cdd.2014.53. Epub 2014 May 2.

PMID:
24786832
[PubMed - in process]
8.

Beta cell imaging - a key tool in optimized diabetes prevention and treatment.

Gotthardt M, Eizirik DL, Cnop M, Brom M.

Trends Endocrinol Metab. 2014 Aug;25(8):375-7. doi: 10.1016/j.tem.2014.02.002. Epub 2014 Apr 11.

PMID:
24726483
[PubMed - in process]
9.

BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.

Marroquí L, Santin I, Dos Santos RS, Marselli L, Marchetti P, Eizirik DL.

Diabetes. 2014 Jul;63(7):2516-27. doi: 10.2337/db13-1443. Epub 2014 Mar 7.

PMID:
24608439
[PubMed - indexed for MEDLINE]
10.

In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes.

Hakonen E, Ustinov J, Eizirik DL, Sariola H, Miettinen PJ, Otonkoski T.

Diabetologia. 2014 May;57(5):970-9. doi: 10.1007/s00125-014-3175-2. Epub 2014 Feb 4.

PMID:
24493201
[PubMed - indexed for MEDLINE]
11.

Non-invasive quantification of the beta cell mass by SPECT with ¹¹¹In-labelled exendin.

Brom M, Woliner-van der Weg W, Joosten L, Frielink C, Bouckenooghe T, Rijken P, Andralojc K, Göke BJ, de Jong M, Eizirik DL, Béhé M, Lahoutte T, Oyen WJ, Tack CJ, Janssen M, Boerman OC, Gotthardt M.

Diabetologia. 2014 May;57(5):950-9. doi: 10.1007/s00125-014-3166-3. Epub 2014 Feb 1.

PMID:
24488022
[PubMed - indexed for MEDLINE]
12.

Temporal profiling of cytokine-induced genes in pancreatic β-cells by meta-analysis and network inference.

Lopes M, Kutlu B, Miani M, Bang-Berthelsen CH, Størling J, Pociot F, Goodman N, Hood L, Welsh N, Bontempi G, Eizirik DL.

Genomics. 2014 Apr;103(4):264-75. doi: 10.1016/j.ygeno.2013.12.007. Epub 2014 Jan 24.

PMID:
24462878
[PubMed - in process]
13.

Discovery of molecular pathways mediating 1,25-dihydroxyvitamin D3 protection against cytokine-induced inflammation and damage of human and male mouse islets of Langerhans.

Wolden-Kirk H, Rondas D, Bugliani M, Korf H, Van Lommel L, Brusgaard K, Christesen HT, Schuit F, Proost P, Masini M, Marchetti P, Eizirik DL, Overbergh L, Mathieu C.

Endocrinology. 2014 Mar;155(3):736-47. doi: 10.1210/en.2013-1409. Epub 2014 Jan 1.

PMID:
24424042
[PubMed - indexed for MEDLINE]
14.

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

Cnop M, Abdulkarim B, Bottu G, Cunha DA, Igoillo-Esteve M, Masini M, Turatsinze JV, Griebel T, Villate O, Santin I, Bugliani M, Ladriere L, Marselli L, McCarthy MI, Marchetti P, Sammeth M, Eizirik DL.

Diabetes. 2014 Jun;63(6):1978-93. doi: 10.2337/db13-1383. Epub 2013 Dec 30.

PMID:
24379348
[PubMed - indexed for MEDLINE]
Free Article
15.

IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets.

Grieco FA, Moore F, Vigneron F, Santin I, Villate O, Marselli L, Rondas D, Korf H, Overbergh L, Dotta F, Marchetti P, Mathieu C, Eizirik DL.

Diabetologia. 2014 Mar;57(3):502-11. doi: 10.1007/s00125-013-3135-2. Epub 2013 Dec 19.

PMID:
24352375
[PubMed - in process]
16.

Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.

Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS.

Sci Transl Med. 2013 Nov 13;5(211):211ra156. doi: 10.1126/scitranslmed.3006534. Erratum in: Sci Transl Med. 2013 Dec 4;5(214):214er11. Ngyuen, Truc [corrected to Nguyen, Truc].

PMID:
24225943
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans.

Igoillo-Esteve M, Genin A, Lambert N, Désir J, Pirson I, Abdulkarim B, Simonis N, Drielsma A, Marselli L, Marchetti P, Vanderhaeghen P, Eizirik DL, Wuyts W, Julier C, Chakera AJ, Ellard S, Hattersley AT, Abramowicz M, Cnop M.

PLoS Genet. 2013 Oct;9(10):e1003888. doi: 10.1371/journal.pgen.1003888. Epub 2013 Oct 31.

PMID:
24204302
[PubMed - in process]
Free PMC Article
18.

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis.

Santin I, Eizirik DL.

Diabetes Obes Metab. 2013 Sep;15 Suppl 3:71-81. doi: 10.1111/dom.12162. Review.

PMID:
24003923
[PubMed - indexed for MEDLINE]
19.

Type 2 diabetes mellitus--an autoimmune disease?

Velloso LA, Eizirik DL, Cnop M.

Nat Rev Endocrinol. 2013 Dec;9(12):750-5. doi: 10.1038/nrendo.2013.131. Epub 2013 Jul 9.

PMID:
23835371
[PubMed - indexed for MEDLINE]
20.

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance.

Miani M, Barthson J, Colli ML, Brozzi F, Cnop M, Eizirik DL.

Cell Death Dis. 2013 Jul 4;4:e701. doi: 10.1038/cddis.2013.236.

PMID:
23828564
[PubMed - indexed for MEDLINE]
Free PMC Article

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