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Results: 1 to 20 of 194

1.

Estimating the activity of transcription factors by the effect on their target genes.

Schacht T, Oswald M, Eils R, Eichmüller SB, König R.

Bioinformatics. 2014 Sep 1;30(17):i401-i407.

PMID:
25161226
[PubMed - as supplied by publisher]
2.

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis.

Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A.

Cell Stem Cell. 2014 Aug 20. pii: S1934-5909(14)00301-4. doi: 10.1016/j.stem.2014.07.005. [Epub ahead of print]

PMID:
25158935
[PubMed - as supplied by publisher]
3.

Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols.

Rohde M, Richter J, Schlesner M, Betts MJ, Claviez A, Bonn BR, Zimmermann M, Damm-Welk C, Russell RB, Borkhardt A, Eils R, Hoell JI, Szczepanowski M, Oschlies I, Klapper W, Burkhardt B, Siebert R; on behalf of the German ICGC MMML-Seq-Project and the NHL-BFM Study Group.

Genes Chromosomes Cancer. 2014 Jul 8. doi: 10.1002/gcc.22202. [Epub ahead of print]

PMID:
25044415
[PubMed - as supplied by publisher]
4.

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Northcott PA, Lee C, Zichner T, Stütz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, Bader GD, VandenBerg S, Esparza LA, Ryzhova M, Wang W, Wittmann A, Stark S, Sieber L, Seker-Cin H, Linke L, Kratochwil F, Jäger N, Buchhalter I, Imbusch CD, Zipprich G, Raeder B, Schmidt S, Diessl N, Wolf S, Wiemann S, Brors B, Lawerenz C, Eils J, Warnatz HJ, Risch T, Yaspo ML, Weber UD, Bartholomae CC, von Kalle C, Turányi E, Hauser P, Sanden E, Darabi A, Siesjö P, Sterba J, Zitterbart K, Sumerauer D, van Sluis P, Versteeg R, Volckmann R, Koster J, Schuhmann MU, Ebinger M, Grimes HL, Robinson GW, Gajjar A, Mynarek M, von Hoff K, Rutkowski S, Pietsch T, Scheurlen W, Felsberg J, Reifenberger G, Kulozik AE, von Deimling A, Witt O, Eils R, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Korbel JO, Wechsler-Reya RJ, Pfister SM.

Nature. 2014 Jul 24;511(7510):428-34. doi: 10.1038/nature13379. Epub 2014 Jun 22.

PMID:
25043047
[PubMed - in process]
5.

Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells.

Niopek D, Benzinger D, Roensch J, Draebing T, Wehler P, Eils R, Di Ventura B.

Nat Commun. 2014 Jul 14;5:4404. doi: 10.1038/ncomms5404.

PMID:
25019686
[PubMed - in process]
Free PMC Article
6.

Dissecting the contribution of actin and vimentin intermediate filaments to mechanical phenotype of suspended cells using high-throughput deformability measurements and computational modeling.

Gladilin E, Gonzalez P, Eils R.

J Biomech. 2014 Aug 22;47(11):2598-605. doi: 10.1016/j.jbiomech.2014.05.020. Epub 2014 Jun 6.

PMID:
24952458
[PubMed - in process]
Free Article
7.

circlize implements and enhances circular visualization in R.

Gu Z, Gu L, Eils R, Schlesner M, Brors B.

Bioinformatics. 2014 Jun 14. pii: btu393. [Epub ahead of print]

PMID:
24930139
[PubMed - as supplied by publisher]
8.

Network topology-based detection of differential gene regulation and regulatory switches in cell metabolism and signaling.

Piro RM, Wiesberg S, Schramm G, Rebel N, Oswald M, Eils R, Reinelt G, König R.

BMC Syst Biol. 2014 May 16;8:56. doi: 10.1186/1752-0509-8-56.

PMID:
24886210
[PubMed - in process]
Free PMC Article
9.

Genetic variants in apoptosis-related genes associated with colorectal hyperplasia.

Gerola S, Nittka S, Kähler G, Tao S, Brenner H, Binelli G, Eils R, Brors B, Neumaier M.

Genes Chromosomes Cancer. 2014 Sep;53(9):769-78. doi: 10.1002/gcc.22185. Epub 2014 May 27.

PMID:
24861865
[PubMed - in process]
10.

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.

Hovestadt V, Jones DT, Picelli S, Wang W, Kool M, Northcott PA, Sultan M, Stachurski K, Ryzhova M, Warnatz HJ, Ralser M, Brun S, Bunt J, Jäger N, Kleinheinz K, Erkek S, Weber UD, Bartholomae CC, von Kalle C, Lawerenz C, Eils J, Koster J, Versteeg R, Milde T, Witt O, Schmidt S, Wolf S, Pietsch T, Rutkowski S, Scheurlen W, Taylor MD, Brors B, Felsberg J, Reifenberger G, Borkhardt A, Lehrach H, Wechsler-Reya RJ, Eils R, Yaspo ML, Landgraf P, Korshunov A, Zapatka M, Radlwimmer B, Pfister SM, Lichter P.

Nature. 2014 Jun 26;510(7506):537-41. doi: 10.1038/nature13268. Epub 2014 May 18.

PMID:
24847876
[PubMed - indexed for MEDLINE]
11.

An RNAi screen identifies KIF15 as a novel regulator of the endocytic trafficking of integrin.

Eskova A, Knapp B, Matelska D, Reusing S, Arjonen A, Lisauskas T, Pepperkok R, Russell R, Eils R, Ivaska J, Kaderali L, Erfle H, Starkuviene V.

J Cell Sci. 2014 Jun 1;127(Pt 11):2433-47. doi: 10.1242/jcs.137281. Epub 2014 Mar 21.

PMID:
24659801
[PubMed - in process]
Free Article
12.

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Kool M, Jones DT, Jäger N, Northcott PA, Pugh TJ, Hovestadt V, Piro RM, Esparza LA, Markant SL, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, Stark S, Hutter S, Seker-Cin H, Johann P, Bender S, Schmidt C, Rausch T, Shih D, Reimand J, Sieber L, Wittmann A, Linke L, Witt H, Weber UD, Zapatka M, König R, Beroukhim R, Bergthold G, van Sluis P, Volckmann R, Koster J, Versteeg R, Schmidt S, Wolf S, Lawerenz C, Bartholomae CC, von Kalle C, Unterberg A, Herold-Mende C, Hofer S, Kulozik AE, von Deimling A, Scheurlen W, Felsberg J, Reifenberger G, Hasselblatt M, Crawford JR, Grant GA, Jabado N, Perry A, Cowdrey C, Croul S, Zadeh G, Korbel JO, Doz F, Delattre O, Bader GD, McCabe MG, Collins VP, Kieran MW, Cho YJ, Pomeroy SL, Witt O, Brors B, Taylor MD, Schüller U, Korshunov A, Eils R, Wechsler-Reya RJ, Lichter P, Pfister SM; ICGC PedBrain Tumor Project.

Cancer Cell. 2014 Mar 17;25(3):393-405. doi: 10.1016/j.ccr.2014.02.004.

PMID:
24651015
[PubMed - indexed for MEDLINE]
13.

Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.

Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S, Eils R.

Sci Signal. 2014 Mar 11;7(316):ra23. doi: 10.1126/scisignal.2004738.

PMID:
24619646
[PubMed - in process]
14.

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.

Mack SC, Witt H, Piro RM, Gu L, Zuyderduyn S, Stütz AM, Wang X, Gallo M, Garzia L, Zayne K, Zhang X, Ramaswamy V, Jäger N, Jones DT, Sill M, Pugh TJ, Ryzhova M, Wani KM, Shih DJ, Head R, Remke M, Bailey SD, Zichner T, Faria CC, Barszczyk M, Stark S, Seker-Cin H, Hutter S, Johann P, Bender S, Hovestadt V, Tzaridis T, Dubuc AM, Northcott PA, Peacock J, Bertrand KC, Agnihotri S, Cavalli FM, Clarke I, Nethery-Brokx K, Creasy CL, Verma SK, Koster J, Wu X, Yao Y, Milde T, Sin-Chan P, Zuccaro J, Lau L, Pereira S, Castelo-Branco P, Hirst M, Marra MA, Roberts SS, Fults D, Massimi L, Cho YJ, Van Meter T, Grajkowska W, Lach B, Kulozik AE, von Deimling A, Witt O, Scherer SW, Fan X, Muraszko KM, Kool M, Pomeroy SL, Gupta N, Phillips J, Huang A, Tabori U, Hawkins C, Malkin D, Kongkham PN, Weiss WA, Jabado N, Rutka JT, Bouffet E, Korbel JO, Lupien M, Aldape KD, Bader GD, Eils R, Lichter P, Dirks PB, Pfister SM, Korshunov A, Taylor MD.

Nature. 2014 Feb 27;506(7489):445-50. doi: 10.1038/nature13108. Epub 2014 Feb 19.

PMID:
24553142
[PubMed - indexed for MEDLINE]
15.

Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange.

Beer R, Herbst K, Ignatiadis N, Kats I, Adlung L, Meyer H, Niopek D, Christiansen T, Georgi F, Kurzawa N, Meichsner J, Rabe S, Riedel A, Sachs J, Schessner J, Schmidt F, Walch P, Niopek K, Heinemann T, Eils R, Di Ventura B.

Mol Biosyst. 2014 Jul;10(7):1709-18. doi: 10.1039/c3mb70594c.

PMID:
24457530
[PubMed - in process]
16.

Decision-tree based model analysis for efficient identification of parameter relations leading to different signaling states.

Koch Y, Wolf T, Sorger PK, Eils R, Brors B.

PLoS One. 2013 Dec 18;8(12):e82593. doi: 10.1371/journal.pone.0082593. eCollection 2013.

PMID:
24367526
[PubMed - in process]
Free PMC Article
17.

Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas.

Renner M, Wolf T, Meyer H, Hartmann W, Penzel R, Ulrich A, Lehner B, Hovestadt V, Czwan E, Egerer G, Schmitt T, Alldinger I, Renker EK, Ehemann V, Eils R, Wardelmann E, Büttner R, Lichter P, Brors B, Schirmacher P, Mechtersheimer G.

Genome Biol. 2013 Dec 17;14(12):r137. doi: 10.1186/gb-2013-14-12-r137.

PMID:
24345474
[PubMed - in process]
Free PMC Article
18.

Efficient keratinocyte differentiation strictly depends on JNK-induced soluble factors in fibroblasts.

Schumacher M, Schuster C, Rogon ZM, Bauer T, Caushaj N, Baars S, Szabowski S, Bauer C, Schorpp-Kistner M, Hess J, Holland-Cunz S, Wagner EF, Eils R, Angel P, Hartenstein B.

J Invest Dermatol. 2014 May;134(5):1332-41. doi: 10.1038/jid.2013.535. Epub 2013 Nov 16.

PMID:
24335928
[PubMed - indexed for MEDLINE]
19.

Genome sequencing: a systematic review of health economic evidence.

Frank M, Prenzler A, Eils R, Graf von der Schulenburg JM.

Health Econ Rev. 2013 Dec 12;3(1):29. doi: 10.1186/2191-1991-3-29.

PMID:
24330507
[PubMed]
Free PMC Article
20.

Hypermutation of the inactive X chromosome is a frequent event in cancer.

Jäger N, Schlesner M, Jones DT, Raffel S, Mallm JP, Junge KM, Weichenhan D, Bauer T, Ishaque N, Kool M, Northcott PA, Korshunov A, Drews RM, Koster J, Versteeg R, Richter J, Hummel M, Mack SC, Taylor MD, Witt H, Swartman B, Schulte-Bockholt D, Sultan M, Yaspo ML, Lehrach H, Hutter B, Brors B, Wolf S, Plass C, Siebert R, Trumpp A, Rippe K, Lehmann I, Lichter P, Pfister SM, Eils R.

Cell. 2013 Oct 24;155(3):567-81. doi: 10.1016/j.cell.2013.09.042. Epub 2013 Oct 17.

PMID:
24139898
[PubMed - indexed for MEDLINE]
Free PMC Article

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