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Results: 1 to 20 of 209

1.

Hypermutation takes the driver's seat.

Schlesner M, Eils R.

Genome Med. 2015 Mar 28;7(1):31. doi: 10.1186/s13073-015-0159-x. eCollection 2015.

PMID:
25821521
2.

SIPA1L3 identified by linkage analysis and whole-exome sequencing as a novel gene for autosomal recessive congenital cataract.

Evers C, Paramasivam N, Hinderhofer K, Fischer C, Granzow M, Schmidt-Bacher A, Eils R, Steinbeisser H, Schlesner M, Moog U.

Eur J Hum Genet. 2015 Mar 25. doi: 10.1038/ejhg.2015.46. [Epub ahead of print]

PMID:
25804400
3.

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic acid induced 2.

Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jucker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefstrom J, Wilmanns M, Muller V, Pantel K, Wikman H.

Cancer Discov. 2015 Feb 25. pii: CD-14-1042. [Epub ahead of print]

PMID:
25716347
4.

Editorial: Synthetic biology - ready for application.

Eils R, Ritzerfeld J, Wiechert W.

Biotechnol J. 2015 Feb;10(2):229-30. doi: 10.1002/biot.201500025. No abstract available.

PMID:
25676050
5.

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.

Wegert J, Ishaque N, Vardapour R, Geörg C, Gu Z, Bieg M, Ziegler B, Bausenwein S, Nourkami N, Ludwig N, Keller A, Grimm C, Kneitz S, Williams RD, Chagtai T, Pritchard-Jones K, van Sluis P, Volckmann R, Koster J, Versteeg R, Acha T, O'Sullivan MJ, Bode PK, Niggli F, Tytgat GA, van Tinteren H, van den Heuvel-Eibrink MM, Meese E, Vokuhl C, Leuschner I, Graf N, Eils R, Pfister SM, Kool M, Gessler M.

Cancer Cell. 2015 Feb 9;27(2):298-311. doi: 10.1016/j.ccell.2015.01.002.

PMID:
25670083
6.

Large-scale tracking and classification for automatic analysis of cell migration and proliferation, and experimental optimization of high-throughput screens of neuroblastoma cells.

Harder N, Batra R, Diessl N, Gogolin S, Eils R, Westermann F, König R, Rohr K.

Cytometry A. 2015 Jan 28. doi: 10.1002/cyto.a.22632. [Epub ahead of print]

PMID:
25630981
7.

BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence.

Gu L, Frommel SC, Oakes CC, Simon R, Grupp K, Gerig CY, Bär D, Robinson MD, Baer C, Weiss M, Gu Z, Schapira M, Kuner R, Sültmann H, Provenzano M; ICGC Project on Early Onset Prostate Cancer, Yaspo ML, Brors B, Korbel J, Schlomm T, Sauter G, Eils R, Plass C, Santoro R.

Nat Genet. 2015 Jan;47(1):22-30. doi: 10.1038/ng.3165. Epub 2014 Dec 8.

PMID:
25485837
8.

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing.

Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wünsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C.

Cell Cycle. 2014;13(22):3476-87. doi: 10.4161/15384101.2014.973334.

PMID:
25483069
9.

A framework for modelling gene regulation which accommodates non-equilibrium mechanisms.

Ahsendorf T, Wong F, Eils R, Gunawardena J.

BMC Biol. 2014 Dec 5;12(1):102. [Epub ahead of print]

10.

Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions.

Betts MJ, Lu Q, Jiang Y, Drusko A, Wichmann O, Utz M, Valtierra-Gutiérrez IA, Schlesner M, Jaeger N, Jones DT, Pfister S, Lichter P, Eils R, Siebert R, Bork P, Apic G, Gavin AC, Russell RB.

Nucleic Acids Res. 2015 Jan;43(2):e10. doi: 10.1093/nar/gku1094. Epub 2014 Nov 11.

11.

Characterizing protein interactions employing a genome-wide siRNA cellular phenotyping screen.

Suratanee A, Schaefer MH, Betts MJ, Soons Z, Mannsperger H, Harder N, Oswald M, Gipp M, Ramminger E, Marcus G, Männer R, Rohr K, Wanker E, Russell RB, Andrade-Navarro MA, Eils R, König R.

PLoS Comput Biol. 2014 Sep 25;10(9):e1003814. doi: 10.1371/journal.pcbi.1003814. eCollection 2014 Sep.

12.

Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers.

Oberthuer A, Juraeva D, Hero B, Volland R, Carolina S, Schmidt R, Faldum A, Kahlert Y, Engesser A, Asgharzadeh S, Seeger RC, Ohira M, Nakagawara A, Scaruffi P, Tonini GP, Janoueix-Lerosey I, Delattre O, Schleiermacher G, Vandesompele J, Speleman F, Noguera R, Piqueras M, Benard J, Valent A, Avigad S, Yaniv I, Grundy RG, Ortmann M, Shao C, Schwab M, Eils R, Simon T, Theissen J, Berthold F, Westermann F, Brors B, Fischer M.

Clin Cancer Res. 2014 Sep 17. pii: clincanres.0817.2014. [Epub ahead of print]

PMID:
25231397
13.

The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing.

Vater I, Montesinos-Rongen M, Schlesner M, Haake A, Purschke F, Sprute R, Mettenmeyer N, Nazzal I, Nagel I, Gutwein J, Richter J, Buchhalter I, Russell RB, Wiestler OD, Eils R, Deckert M, Siebert R.

Leukemia. 2015 Mar;29(3):677-85. doi: 10.1038/leu.2014.264. Epub 2014 Sep 5.

PMID:
25189415
14.

Data-derived modeling characterizes plasticity of MAPK signaling in melanoma.

Bernardo-Faura M, Massen S, Falk CS, Brady NR, Eils R.

PLoS Comput Biol. 2014 Sep 4;10(9):e1003795. doi: 10.1371/journal.pcbi.1003795. eCollection 2014 Sep.

15.

Non-rigid multi-frame registration of cell nuclei in live cell fluorescence microscopy image data.

Tektonidis M, Kim IH, Chen YC, Eils R, Spector DL, Rohr K.

Med Image Anal. 2015 Jan;19(1):1-14. doi: 10.1016/j.media.2014.07.006. Epub 2014 Aug 11.

PMID:
25181702
16.

Estimating the activity of transcription factors by the effect on their target genes.

Schacht T, Oswald M, Eils R, Eichmüller SB, König R.

Bioinformatics. 2014 Sep 1;30(17):i401-7. doi: 10.1093/bioinformatics/btu446.

17.

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA Methylome analysis.

Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A.

Cell Stem Cell. 2014 Oct 2;15(4):507-22. doi: 10.1016/j.stem.2014.07.005. Epub 2014 Aug 21.

PMID:
25158935
18.

Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols.

Rohde M, Richter J, Schlesner M, Betts MJ, Claviez A, Bonn BR, Zimmermann M, Damm-Welk C, Russell RB, Borkhardt A, Eils R, Hoell JI, Szczepanowski M, Oschlies I, Klapper W, Burkhardt B, Siebert R; German ICGC MMML-Seq-Project; NHL-BFM Study Group.

Genes Chromosomes Cancer. 2014 Nov;53(11):911-6. doi: 10.1002/gcc.22202. Epub 2014 Jul 8.

PMID:
25044415
19.

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Northcott PA, Lee C, Zichner T, Stütz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, Bader GD, VandenBerg S, Esparza LA, Ryzhova M, Wang W, Wittmann A, Stark S, Sieber L, Seker-Cin H, Linke L, Kratochwil F, Jäger N, Buchhalter I, Imbusch CD, Zipprich G, Raeder B, Schmidt S, Diessl N, Wolf S, Wiemann S, Brors B, Lawerenz C, Eils J, Warnatz HJ, Risch T, Yaspo ML, Weber UD, Bartholomae CC, von Kalle C, Turányi E, Hauser P, Sanden E, Darabi A, Siesjö P, Sterba J, Zitterbart K, Sumerauer D, van Sluis P, Versteeg R, Volckmann R, Koster J, Schuhmann MU, Ebinger M, Grimes HL, Robinson GW, Gajjar A, Mynarek M, von Hoff K, Rutkowski S, Pietsch T, Scheurlen W, Felsberg J, Reifenberger G, Kulozik AE, von Deimling A, Witt O, Eils R, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Korbel JO, Wechsler-Reya RJ, Pfister SM.

Nature. 2014 Jul 24;511(7510):428-34. doi: 10.1038/nature13379. Epub 2014 Jun 22.

PMID:
25043047
20.

Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells.

Niopek D, Benzinger D, Roensch J, Draebing T, Wehler P, Eils R, Di Ventura B.

Nat Commun. 2014 Jul 14;5:4404. doi: 10.1038/ncomms5404.

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