Survival and quantitative organ culture of mice infected intranasally with 54 spores of C. posadasii and treated for 19 days with 20 mg/kg or 50 mg/kg of KOSN-2079 or KOSN-2089. (A) Survival curve for treated mice. All treatments provide prolonged survival compared to the vehicle alone (P < 0.01), and KOSN-2089 at 50 mg/kg results in significantly improved survival compared to KOSN-2079 at either dose (P < 0.05). KOSN-2089 at 20 mg/kg was not significantly different from the KOSN-2079 doses. Solid triangles, KOSN-2079 at 20 mg/kg (n = 9); open triangles, KOSN-2079 at 50 mg/kg (n = 10); solid squares, KOSN-2089 at 20 mg/kg (n = 9); open squares, KOSN-2089 at 50 mg/kg (n = 7); solid circles, vehicle only (n = 6). (B) Quantitative lung cultures for treated mice. KOSN-2089 at 50 mg/kg yielded significantly lower lung fungal burdens than all other treatments (P ≤ 0.006). All treatments reduced lung fungal burdens compared to the vehicle control (HPBC) (P < 0.01).