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Int J Radiat Oncol Biol Phys. 2009 Sep 1;75(1):276-84. doi: 10.1016/j.ijrobp.2009.03.051. Epub 2009 Jun 18.

Dynamic MRI of grid-tagged hyperpolarized helium-3 for the assessment of lung motion during breathing.

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  • 1Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.

Abstract

PURPOSE:

To develop a dynamic magnetic resonance imaging (MRI) tagging technique using hyperpolarized helium-3 (HP He-3) to track lung motion.

METHODS AND MATERIALS:

An accelerated non-Cartesian k-space trajectory was used to gain acquisition speed, at the cost of introducing image artifacts, providing a viable strategy for obtaining whole-lung coverage with adequate temporal resolution. Multiple-slice two-dimensional dynamic images of the lung were obtained in three healthy subjects after inhaling He-3 gas polarized to 35%-40%. Displacement, strain, and ventilation maps were computed from the observed motion of the grid peaks.

RESULTS:

Both temporal and spatial variations of pulmonary mechanics were observed in normal subjects, including shear motion between different lobes of the same lung.

CONCLUSION:

These initial results suggest that dynamic imaging of grid-tagged hyperpolarized magnetization may potentially be a powerful tool for observing and quantifying pulmonary biomechanics on a regional basis and for assessing, validating, and improving lung deformable image registration algorithms.

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