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Structure of the poly-C9 component of the complement membrane attack complex.

Dudkina NV, Spicer BA, Reboul CF, Conroy PJ, Lukoyanova N, Elmlund H, Law RH, Ekkel SM, Kondos SC, Goode RJ, Ramm G, Whisstock JC, Saibil HR, Dunstone MA.

Nat Commun. 2016 Feb 4;7:10588. doi: 10.1038/ncomms10588.


Stonefish toxin defines an ancient branch of the perforin-like superfamily.

Ellisdon AM, Reboul CF, Panjikar S, Huynh K, Oellig CA, Winter KL, Dunstone MA, Hodgson WC, Seymour J, Dearden PK, Tweten RK, Whisstock JC, McGowan S.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15360-5. doi: 10.1073/pnas.1507622112. Epub 2015 Dec 1.


Giant MACPF/CDC pore forming toxins: A class of their own.

Reboul CF, Whisstock JC, Dunstone MA.

Biochim Biophys Acta. 2016 Mar;1858(3):475-86. doi: 10.1016/j.bbamem.2015.11.017. Epub 2015 Nov 26.


Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA.

PLoS Biol. 2015 Feb 5;13(2):e1002049. doi: 10.1371/journal.pbio.1002049. eCollection 2015 Feb.


Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin.

Leung C, Dudkina NV, Lukoyanova N, Hodel AW, Farabella I, Pandurangan AP, Jahan N, Pires Damaso M, Osmanović D, Reboul CF, Dunstone MA, Andrew PW, Lonnen R, Topf M, Saibil HR, Hoogenboom BW.

Elife. 2014 Dec 2;3:e04247. doi: 10.7554/eLife.04247. Erratum in: Elife. 2014;4:e06740.


A new model for pore formation by cholesterol-dependent cytolysins.

Reboul CF, Whisstock JC, Dunstone MA.

PLoS Comput Biol. 2014 Aug 21;10(8):e1003791. doi: 10.1371/journal.pcbi.1003791. eCollection 2014 Aug.


The cellular redox environment alters antigen presentation.

Trujillo JA, Croft NP, Dudek NL, Channappanavar R, Theodossis A, Webb AI, Dunstone MA, Illing PT, Butler NS, Fett C, Tscharke DC, Rossjohn J, Perlman S, Purcell AW.

J Biol Chem. 2014 Oct 3;289(40):27979-91. doi: 10.1074/jbc.M114.573402. Epub 2014 Aug 18.


The perforin pore facilitates the delivery of cationic cargos.

Stewart SE, Kondos SC, Matthews AY, D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI.

J Biol Chem. 2014 Mar 28;289(13):9172-81. doi: 10.1074/jbc.M113.544890. Epub 2014 Feb 20.


Structural biology: Torqueing about pores.

Whisstock JC, Dunstone MA.

Nat Chem Biol. 2013 Oct;9(10):605-6. doi: 10.1038/nchembio.1341.


Screening of 71 P. multocida proteins for protective efficacy in a fowl cholera infection model and characterization of the protective antigen PlpE.

Hatfaludi T, Al-Hasani K, Gong L, Boyce JD, Ford M, Wilkie IW, Quinsey N, Dunstone MA, Hoke DE, Adler B.

PLoS One. 2012;7(7):e39973. doi: 10.1371/journal.pone.0039973. Epub 2012 Jul 5.


Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.

Dunstone MA, Tweten RK.

Curr Opin Struct Biol. 2012 Jun;22(3):342-9. doi: 10.1016/ Epub 2012 May 31. Review.


Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi.

D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI.

BMC Evol Biol. 2012 May 2;12:59. doi: 10.1186/1471-2148-12-59.


Predicting giant transmembrane β-barrel architecture.

Reboul CF, Mahmood K, Whisstock JC, Dunstone MA.

Bioinformatics. 2012 May 15;28(10):1299-302. doi: 10.1093/bioinformatics/bts152. Epub 2012 Mar 30.


Crystallography of serpins and serpin complexes.

Dunstone MA, Whisstock JC.

Methods Enzymol. 2011;501:63-87. doi: 10.1016/B978-0-12-385950-1.00005-5.


The structural basis for membrane binding and pore formation by lymphocyte perforin.

Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC.

Nature. 2010 Nov 18;468(7322):447-51. doi: 10.1038/nature09518. Epub 2010 Oct 31.


The structure and function of mammalian membrane-attack complex/perforin-like proteins.

Kondos SC, Hatfaludi T, Voskoboinik I, Trapani JA, Law RH, Whisstock JC, Dunstone MA.

Tissue Antigens. 2010 Nov;76(5):341-51. doi: 10.1111/j.1399-0039.2010.01566.x. Epub 2010 Sep 22. Review.


Perforin: structure, function, and role in human immunopathology.

Voskoboinik I, Dunstone MA, Baran K, Whisstock JC, Trapani JA.

Immunol Rev. 2010 May;235(1):35-54. doi: 10.1111/j.0105-2896.2010.00896.x. Review.


The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

Newton HJ, Pearson JS, Badea L, Kelly M, Lucas M, Holloway G, Wagstaff KM, Dunstone MA, Sloan J, Whisstock JC, Kaper JB, Robins-Browne RM, Jans DA, Frankel G, Phillips AD, Coulson BS, Hartland EL.

PLoS Pathog. 2010 May 13;6(5):e1000898. doi: 10.1371/journal.ppat.1000898.


Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.

Theodossis A, Guillonneau C, Welland A, Ely LK, Clements CS, Williamson NA, Webb AI, Wilce JA, Mulder RJ, Dunstone MA, Doherty PC, McCluskey J, Purcell AW, Turner SJ, Rossjohn J.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5534-9. doi: 10.1073/pnas.1000032107. Epub 2010 Mar 8.


Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer.

Chia J, Yeo KP, Whisstock JC, Dunstone MA, Trapani JA, Voskoboinik I.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9809-14. doi: 10.1073/pnas.0903815106. Epub 2009 Jun 1.

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