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Results: 1 to 20 of 29

1.

The perforin pore facilitates the delivery of cationic cargos.

Stewart SE, Kondos SC, Matthews AY, D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI.

J Biol Chem. 2014 Mar 28;289(13):9172-81. doi: 10.1074/jbc.M113.544890. Epub 2014 Feb 20.

PMID:
24558045
[PubMed - indexed for MEDLINE]
2.

Structural biology: Torqueing about pores.

Whisstock JC, Dunstone MA.

Nat Chem Biol. 2013 Oct;9(10):605-6. doi: 10.1038/nchembio.1341.

PMID:
24045807
[PubMed - indexed for MEDLINE]
3.

Screening of 71 P. multocida proteins for protective efficacy in a fowl cholera infection model and characterization of the protective antigen PlpE.

Hatfaludi T, Al-Hasani K, Gong L, Boyce JD, Ford M, Wilkie IW, Quinsey N, Dunstone MA, Hoke DE, Adler B.

PLoS One. 2012;7(7):e39973. doi: 10.1371/journal.pone.0039973. Epub 2012 Jul 5.

PMID:
22792202
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.

Dunstone MA, Tweten RK.

Curr Opin Struct Biol. 2012 Jun;22(3):342-9. doi: 10.1016/j.sbi.2012.04.008. Epub 2012 May 31. Review.

PMID:
22658510
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi.

D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI.

BMC Evol Biol. 2012 May 2;12:59. doi: 10.1186/1471-2148-12-59.

PMID:
22551122
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Predicting giant transmembrane β-barrel architecture.

Reboul CF, Mahmood K, Whisstock JC, Dunstone MA.

Bioinformatics. 2012 May 15;28(10):1299-302. doi: 10.1093/bioinformatics/bts152. Epub 2012 Mar 30.

PMID:
22467914
[PubMed - indexed for MEDLINE]
Free Article
7.

Crystallography of serpins and serpin complexes.

Dunstone MA, Whisstock JC.

Methods Enzymol. 2011;501:63-87. doi: 10.1016/B978-0-12-385950-1.00005-5.

PMID:
22078531
[PubMed - indexed for MEDLINE]
8.

The structural basis for membrane binding and pore formation by lymphocyte perforin.

Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC.

Nature. 2010 Nov 18;468(7322):447-51. doi: 10.1038/nature09518. Epub 2010 Oct 31.

PMID:
21037563
[PubMed - indexed for MEDLINE]
9.

The structure and function of mammalian membrane-attack complex/perforin-like proteins.

Kondos SC, Hatfaludi T, Voskoboinik I, Trapani JA, Law RH, Whisstock JC, Dunstone MA.

Tissue Antigens. 2010 Nov;76(5):341-51. doi: 10.1111/j.1399-0039.2010.01566.x. Epub 2010 Sep 22. Review.

PMID:
20860583
[PubMed - indexed for MEDLINE]
10.

Perforin: structure, function, and role in human immunopathology.

Voskoboinik I, Dunstone MA, Baran K, Whisstock JC, Trapani JA.

Immunol Rev. 2010 May;235(1):35-54. doi: 10.1111/j.0105-2896.2010.00896.x. Review.

PMID:
20536554
[PubMed - indexed for MEDLINE]
11.

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

Newton HJ, Pearson JS, Badea L, Kelly M, Lucas M, Holloway G, Wagstaff KM, Dunstone MA, Sloan J, Whisstock JC, Kaper JB, Robins-Browne RM, Jans DA, Frankel G, Phillips AD, Coulson BS, Hartland EL.

PLoS Pathog. 2010 May 13;6(5):e1000898. doi: 10.1371/journal.ppat.1000898.

PMID:
20485572
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.

Theodossis A, Guillonneau C, Welland A, Ely LK, Clements CS, Williamson NA, Webb AI, Wilce JA, Mulder RJ, Dunstone MA, Doherty PC, McCluskey J, Purcell AW, Turner SJ, Rossjohn J.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5534-9. doi: 10.1073/pnas.1000032107. Epub 2010 Mar 8.

PMID:
20212169
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer.

Chia J, Yeo KP, Whisstock JC, Dunstone MA, Trapani JA, Voskoboinik I.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9809-14. doi: 10.1073/pnas.0903815106. Epub 2009 Jun 1.

PMID:
19487666
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.

Beddoe T, Chen Z, Clements CS, Ely LK, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu YC, Macdonald WA, Perugini MA, Wilce MC, Burrows SR, Purcell AW, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J.

Immunity. 2009 Jun 19;30(6):777-88. doi: 10.1016/j.immuni.2009.03.018. Epub 2009 May 21.

PMID:
19464197
[PubMed - indexed for MEDLINE]
Free Article
15.

Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant.

Butler NS, Theodossis A, Webb AI, Nastovska R, Ramarathinam SH, Dunstone MA, Rossjohn J, Purcell AW, Perlman S.

PLoS Pathog. 2008 Oct;4(10):e1000186. doi: 10.1371/journal.ppat.1000186. Epub 2008 Oct 24.

PMID:
18949029
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The MACPF/CDC family of pore-forming toxins.

Rosado CJ, Kondos S, Bull TE, Kuiper MJ, Law RH, Buckle AM, Voskoboinik I, Bird PI, Trapani JA, Whisstock JC, Dunstone MA.

Cell Microbiol. 2008 Sep;10(9):1765-74. doi: 10.1111/j.1462-5822.2008.01191.x. Epub 2008 Jun 28. Review.

PMID:
18564372
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.

Sansom FM, Riedmaier P, Newton HJ, Dunstone MA, Müller CE, Stephan H, Byres E, Beddoe T, Rossjohn J, Cowan PJ, d'Apice AJ, Robson SC, Hartland EL.

J Biol Chem. 2008 May 9;283(19):12909-18. doi: 10.1074/jbc.M801006200. Epub 2008 Mar 12.

PMID:
18337253
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Structural and biological basis of CTL escape in coronavirus-infected mice.

Butler NS, Theodossis A, Webb AI, Dunstone MA, Nastovska R, Ramarathinam SH, Rossjohn J, Purcell AW, Perlman S.

J Immunol. 2008 Mar 15;180(6):3926-37.

PMID:
18322201
[PubMed - indexed for MEDLINE]
Free Article
19.

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides.

La Gruta NL, Thomas PG, Webb AI, Dunstone MA, Cukalac T, Doherty PC, Purcell AW, Rossjohn J, Turner SJ.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2034-9. doi: 10.1073/pnas.0711682102. Epub 2008 Jan 31.

PMID:
18238896
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A common fold mediates vertebrate defense and bacterial attack.

Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC.

Science. 2007 Sep 14;317(5844):1548-51. Epub 2007 Aug 23.

PMID:
17717151
[PubMed - indexed for MEDLINE]
Free Article

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