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Results: 1 to 20 of 35

1.

Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing.

Mennenga SE, Gerson JE, Dunckley T, Bimonte-Nelson HA.

Physiol Behav. 2015 Jan;138:260-5. doi: 10.1016/j.physbeh.2014.09.001. Epub 2014 Sep 22.

PMID:
25250831
2.

SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.

Henderson-Smith A, Chow D, Meechoovet B, Aziz M, Jacobson SA, Shill HA, Sabbagh MN, Caviness JN, Adler CH, Driver-Dunckley ED, Beach TG, Yin H, Dunckley T.

PLoS One. 2013 Oct 30;8(10):e77711. doi: 10.1371/journal.pone.0077711. eCollection 2013.

3.

Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?

Smith B, Medda F, Gokhale V, Dunckley T, Hulme C.

ACS Chem Neurosci. 2012 Nov 21;3(11):857-72. doi: 10.1021/cn300094k. Epub 2012 Aug 28. Review.

4.

β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites.

Frost D, Meechoovet B, Wang T, Gately S, Giorgetti M, Shcherbakova I, Dunckley T.

PLoS One. 2011 May 6;6(5):e19264. doi: 10.1371/journal.pone.0019264.

5.

High-content RNA interference assay: analysis of tau hyperphosphorylation as a generic paradigm.

Robeson RH, Dunckley T.

Methods Mol Biol. 2011;700:221-38. doi: 10.1007/978-1-61737-954-3_15.

PMID:
21204037
6.

Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOEε4 carriers.

Liang WS, Chen K, Lee W, Sidhar K, Corneveaux JJ, Allen AN, Myers A, Villa S, Meechoovet B, Pruzin J, Bandy D, Fleisher AS, Langbaum JB, Huentelman MJ, Jensen K, Dunckley T, Caselli RJ, Kaib S, Reiman EM.

Neuroimage. 2011 Feb 1;54(3):1896-902. doi: 10.1016/j.neuroimage.2010.09.066. Epub 2010 Oct 1. Erratum in: Neuroimage. 2011 Oct 1;58(3):974.

7.

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.

Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, O'Reilly S, Chibnik LB, Shulman JM, Singleton AB, Craig DW, Van Keuren-Jensen KR, Dunckley T, Bennett DA, De Jager PL, Heward C, Hardy J, Reiman EM, Huentelman MJ.

Hum Mol Genet. 2010 Aug 15;19(16):3295-301. doi: 10.1093/hmg/ddq221. Epub 2010 Jun 9.

8.

FUS mutations in sporadic amyotrophic lateral sclerosis.

Lai SL, Abramzon Y, Schymick JC, Stephan DA, Dunckley T, Dillman A, Cookson M, Calvo A, Battistini S, Giannini F, Caponnetto C, Mancardi GL, Spataro R, Monsurro MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Lombardo F; ITALSGEN Consortium, Mora G, Restagno G, Chiò A, Traynor BJ.

Neurobiol Aging. 2011 Mar;32(3):550.e1-4. doi: 10.1016/j.neurobiolaging.2009.12.020. Epub 2010 Feb 6.

9.

High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.

Azorsa DO, Robeson RH, Frost D, Meec hoovet B, Brautigam GR, Dickey C, Beaudry C, Basu GD, Holz DR, Hernandez JA, Bisanz KM, Gwinn L, Grover A, Rogers J, Reiman EM, Hutton M, Stephan DA, Mousses S, Dunckley T.

BMC Genomics. 2010 Jan 12;11:25. doi: 10.1186/1471-2164-11-25.

10.

Evidence for an association between KIBRA and late-onset Alzheimer's disease.

Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ.

Neurobiol Aging. 2010 Jun;31(6):901-9. doi: 10.1016/j.neurobiolaging.2008.07.014. Epub 2008 Sep 13.

11.

Neuronal gene expression correlates of Parkinson's disease with dementia.

Stamper C, Siegel A, Liang WS, Pearson JV, Stephan DA, Shill H, Connor D, Caviness JN, Sabbagh M, Beach TG, Adler CH, Dunckley T.

Mov Disord. 2008 Aug 15;23(11):1588-95. doi: 10.1002/mds.22184.

12.

Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology.

Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA.

Neurobiol Aging. 2010 Apr;31(4):549-66. doi: 10.1016/j.neurobiolaging.2008.05.013. Epub 2008 Jun 24.

13.

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.

Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, Niedzielko TL, Schneider LE, Mastroeni D, Caselli R, Kukull W, Morris JC, Hulette CM, Schmechel D, Rogers J, Stephan DA.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4441-6. doi: 10.1073/pnas.0709259105. Epub 2008 Mar 10.

14.

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA.

Physiol Genomics. 2008 Apr 22;33(2):240-56. doi: 10.1152/physiolgenomics.00242.2007. Epub 2008 Feb 12.

15.

Genomic and Proteomic Biomarker Discovery in Neurological Disease.

Robeson RH, Siegel AM, Dunckley T.

Biomark Insights. 2008 Feb 9;3:73-86.

16.

Whole-genome analysis of sporadic amyotrophic lateral sclerosis.

Dunckley T, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, Halperin RF, Stamper C, Jensen KR, Letizia D, Hesterlee SE, Pestronk A, Levine T, Bertorini T, Graves MC, Mozaffar T, Jackson CE, Bosch P, McVey A, Dick A, Barohn R, Lomen-Hoerth C, Rosenfeld J, O'connor DT, Zhang K, Crook R, Ryberg H, Hutton M, Katz J, Simpson EP, Mitsumoto H, Bowser R, Miller RG, Appel SH, Stephan DA.

N Engl J Med. 2007 Aug 23;357(8):775-88. Epub 2007 Aug 1.

17.

GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.

Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA.

Neuron. 2007 Jun 7;54(5):713-20.

18.
19.

Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.

Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Walker DG, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette C, Schmechel D, Alexander GE, Reiman EM, Rogers J, Stephan DA.

Physiol Genomics. 2007 Feb 12;28(3):311-22. Epub 2006 Oct 31.

20.

Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells.

Dunckley T, Lukas RJ.

Brain Res. 2006 Oct 20;1116(1):39-49. Epub 2006 Sep 1.

PMID:
16949557
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