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The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury.

Rübig E, Stypmann J, Van Slyke P, Dumont DJ, Spieker T, Buscher K, Reuter S, Goerge T, Pavenstädt H, Kümpers P.

Sci Rep. 2016 Feb 25;6:22111. doi: 10.1038/srep22111.


Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.

Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2472-7. doi: 10.1073/pnas.1519467113. Epub 2016 Feb 16.


The Tie2-agonist Vasculotide rescues mice from influenza virus infection.

Sugiyama MG, Armstrong SM, Wang C, Hwang D, Leong-Poi H, Advani A, Advani S, Zhang H, Szaszi K, Tabuchi A, Kuebler WM, Van Slyke P, Dumont DJ, Lee WL.

Sci Rep. 2015 Jun 5;5:11030. doi: 10.1038/srep11030.


Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model.

Korpela E, Yohan D, Chin LC, Kim A, Huang X, Sade S, Van Slyke P, Dumont DJ, Liu SK.

BMC Cancer. 2014 Aug 26;14:614. doi: 10.1186/1471-2407-14-614.


Perioperative cardiovascular system failure in South Asians undergoing cardiopulmonary bypass is associated with prolonged inflammation and increased Toll-like receptor signaling in inflammatory monocytes.

Trop S, Marshall JC, Mazer CD, Gupta M, Dumont DJ, Bourdeau A, Verma S.

J Surg Res. 2014 Mar;187(1):43-52. doi: 10.1016/j.jss.2013.09.035. Epub 2013 Oct 7.


Cell-cell interactions influence vascular reprogramming by Prox1 during embryonic development.

Kim H, Cruz M, Bourdeau A, Dumont DJ.

PLoS One. 2013;8(1):e52197. doi: 10.1371/journal.pone.0052197. Epub 2013 Jan 14.


Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited.

Plate KH, Scholz A, Dumont DJ.

Acta Neuropathol. 2012 Dec;124(6):763-75. doi: 10.1007/s00401-012-1066-5. Epub 2012 Nov 11. Review.


Inhibition of T cell protein tyrosine phosphatase enhances interleukin-18-dependent hematopoietic stem cell expansion.

Bourdeau A, Trop S, Doody KM, Dumont DJ, Tremblay ML.

Stem Cells. 2013 Feb;31(2):293-304. doi: 10.1002/stem.1276. Erratum in: Stem Cells. 2013 Jun;31(6):1224. Tremblayef, Michel L [corrected to Tremblay, Michel L].


Tie2-dependent neovascularization of the ischemic hindlimb is mediated by angiopoietin-2.

Lekas M, Lekas P, Mei SH, Deng Y, Dumont DJ, Stewart DJ.

PLoS One. 2012;7(9):e43568. doi: 10.1371/journal.pone.0043568. Epub 2012 Sep 25.


Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation.

Cai Q, Brissova M, Reinert RB, Pan FC, Brahmachary P, Jeansson M, Shostak A, Radhika A, Poffenberger G, Quaggin SE, Jerome WG, Dumont DJ, Powers AC.

Dev Biol. 2012 Jul 1;367(1):40-54. doi: 10.1016/j.ydbio.2012.04.022. Epub 2012 Apr 24.


Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling.

Chang L, Noseda M, Higginson M, Ly M, Patenaude A, Fuller M, Kyle AH, Minchinton AI, Puri MC, Dumont DJ, Karsan A.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):6993-8. doi: 10.1073/pnas.1118512109. Epub 2012 Apr 16.


The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.

Kumpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park JK, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, Shushakova N.

Crit Care. 2011;15(5):R261. Epub 2011 Oct 31.


Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent manner.

Scholz A, Lang V, Henschler R, Czabanka M, Vajkoczy P, Chavakis E, Drynski J, Harter PN, Mittelbronn M, Dumont DJ, Plate KH, Reiss Y.

Blood. 2011 Nov 3;118(18):5050-9. doi: 10.1182/blood-2011-03-343293. Epub 2011 Aug 25.


Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats.

Jalali S, Huang Y, Dumont DJ, Hynynen K.

BMC Neurol. 2010 Nov 15;10:114. doi: 10.1186/1471-2377-10-114.


25-Hydroxycholesterol exerts both a cox-2-dependent transient proliferative effect and cox-2-independent cytotoxic effect on bovine endothelial cells in a time- and cell-type-dependent manner.

Nguyen VP, Chen SH, Pizzuto K, Cantarutti A, Terminesi A, Mendonca C, Dumont DJ.

J Angiogenes Res. 2010 Nov 11;2:24. doi: 10.1186/2040-2384-2-24.


Tyrosine phosphorylation of Grb14 by Tie2.

Sturk C, Dumont DJ.

Cell Commun Signal. 2010 Oct 25;8:30. doi: 10.1186/1478-811X-8-30.


Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature.

Kim H, Nguyen VP, Petrova TV, Cruz M, Alitalo K, Dumont DJ.

BMC Dev Biol. 2010 Jun 28;10:72. doi: 10.1186/1471-213X-10-72.


Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections.

Tuer A, Tokarz D, Prent N, Cisek R, Alami J, Dumont DJ, Bakueva L, Rowlands J, Barzda V.

J Biomed Opt. 2010 Mar-Apr;15(2):026018. doi: 10.1117/1.3382908.


The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis.

Lakhanpal GK, Vecchiarelli-Federico LM, Li YJ, Cui JW, Bailey ML, Spaner DE, Dumont DJ, Barber DL, Ben-David Y.

Blood. 2010 Jul 22;116(3):428-36. doi: 10.1182/blood-2009-10-250217. Epub 2010 May 5.


Differential proteomic analysis of lymphatic, venous, and arterial endothelial cells extracted from bovine mesenteric vessels.

Nguyen VP, Hanna G, Rodrigues N, Pizzuto K, Yang E, Van Slyke P, Kim H, Chen SH, Dumont DJ.

Proteomics. 2010 Apr;10(8):1658-72. doi: 10.1002/pmic.200900594.

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