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Items: 11


Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease.

Raththagala M, Brewer MK, Parker MW, Sherwood AR, Wong BK, Hsu S, Bridges TM, Paasch BC, Hellman LM, Husodo S, Meekins DA, Taylor AO, Turner BD, Auger KD, Dukhande VV, Chakravarthy S, Sanz P, Woods VL Jr, Li S, Vander Kooi CW, Gentry MS.

Mol Cell. 2015 Jan 22;57(2):261-72. doi: 10.1016/j.molcel.2014.11.020. Epub 2014 Dec 24.


Expression, purification and characterization of soluble red rooster laforin as a fusion protein in Escherichia coli.

Brewer MK, Husodo S, Dukhande VV, Johnson MB, Gentry MS.

BMC Biochem. 2014 Apr 2;15:8. doi: 10.1186/1471-2091-15-8.


Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione.

Dukhande VV, Kawikova I, Bothwell AL, Lai JC.

Apoptosis. 2013 Jun;18(6):702-12. doi: 10.1007/s10495-013-0836-4.


Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity.

Dukhande VV, Rogers DM, Romá-Mateo C, Donderis J, Marina A, Taylor AO, Sanz P, Gentry MS.

PLoS One. 2011;6(8):e24040. doi: 10.1371/journal.pone.0024040. Epub 2011 Aug 26.


Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase.

Romá-Mateo C, Solaz-Fuster Mdel C, Gimeno-Alcañiz JV, Dukhande VV, Donderis J, Worby CA, Marina A, Criado O, Koller A, Rodriguez De Cordoba S, Gentry MS, Sanz P.

Biochem J. 2011 Oct 15;439(2):265-75. doi: 10.1042/BJ20110150.


Chronic hypoxia-induced alterations of key enzymes of glucose oxidative metabolism in developing mouse liver are mTOR dependent.

Dukhande VV, Sharma GC, Lai JC, Farahani R.

Mol Cell Biochem. 2011 Nov;357(1-2):189-97. doi: 10.1007/s11010-011-0889-z. Epub 2011 May 28.


Treatment of human astrocytoma U87 cells with silicon dioxide nanoparticles lowers their survival and alters their expression of mitochondrial and cell signaling proteins.

Lai JC, Ananthakrishnan G, Jandhyam S, Dukhande VV, Bhushan A, Gokhale M, Daniels CK, Leung SW.

Int J Nanomedicine. 2010 Oct 5;5:715-23. doi: 10.2147/IJN.S5238. Erratum in: Int J Nanomedicine. 2011;6:33.


Reduced glutathione regenerating enzymes undergo developmental decline and sexual dimorphism in the rat cerebral cortex.

Dukhande VV, Isaac AO, Chatterji T, Lai JC.

Brain Res. 2009 Aug 25;1286:19-24. doi: 10.1016/j.brainres.2009.05.029. Epub 2009 May 18.


Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts.

Lai JC, Lai MB, Jandhyam S, Dukhande VV, Bhushan A, Daniels CK, Leung SW.

Int J Nanomedicine. 2008;3(4):533-45.


Metabolic and antioxidant system alterations in an astrocytoma cell line challenged with mitochondrial DNA deletion.

Isaac AO, Dukhande VV, Lai JC.

Neurochem Res. 2007 Nov;32(11):1906-18. Epub 2007 Jun 12.


Manganese-induced neurotoxicity is differentially enhanced by glutathione depletion in astrocytoma and neuroblastoma cells.

Dukhande VV, Malthankar-Phatak GH, Hugus JJ, Daniels CK, Lai JC.

Neurochem Res. 2006 Nov;31(11):1349-57. Epub 2006 Oct 20.

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