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Results: 1 to 20 of 176

1.

Structure Driven Design of Novel Human Ether-A-Go-Go-Related-Gene Channel (hERG1) Activators.

Guo J, Durdagi S, Changalov M, Perissinotti LL, Hargreaves JM, Back TG, Noskov SY, Duff HJ.

PLoS One. 2014 Sep 5;9(9):e105553. doi: 10.1371/journal.pone.0105553. eCollection 2014.

PMID:
25191697
[PubMed - in process]
Free PMC Article
2.

The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study.

Ezekowitz JA, Becher H, Belenkie I, Clark AM, Duff HJ, Friedrich MG, Haykowsky MJ, Howlett JG, Kassiri Z, Kaul P, Kim DH, Knudtson ML, Light PE, Lopaschuk GD, McAlister FA, Noga ML, Oudit GY, Paterson DI, Quan H, Schulz R, Thompson RB, Weeks SG, Anderson TJ, Dyck JR.

BMC Cardiovasc Disord. 2014 Jul 25;14(1):91. [Epub ahead of print]

PMID:
25063541
[PubMed - as supplied by publisher]
Free Article
3.

Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.

Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR Jr, Fedak PW, Beck PL, Muruve DA, Duff HJ.

J Biol Chem. 2014 Jul 11;289(28):19571-84. doi: 10.1074/jbc.M114.550624. Epub 2014 May 19.

PMID:
24841199
[PubMed - in process]
4.

Rehabilitating drug-induced long-QT promoters: in-silico design of hERG-neutral cisapride analogues with retained pharmacological activity.

Durdagi S, Randall T, Duff HJ, Chamberlin A, Noskov SY.

BMC Pharmacol Toxicol. 2014 Mar 8;15(1):14. doi: 10.1186/2050-6511-15-14.

PMID:
24606761
[PubMed - in process]
Free PMC Article
5.

Beyond doctrine and dogma: one gene--multisystem effects.

Duff HJ.

Circ Cardiovasc Genet. 2014 Feb;7(1):4. doi: 10.1161/CIRCGENETICS.114.000508. No abstract available.

PMID:
24550429
[PubMed - in process]
6.

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.

Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR.

Nat Med. 2014 Feb;20(2):184-92. doi: 10.1038/nm.3440. Epub 2014 Jan 19.

PMID:
24441828
[PubMed - indexed for MEDLINE]
7.

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.

Gerull B, Kirchner F, Chong JX, Tagoe J, Chandrasekharan K, Strohm O, Waggoner D, Ober C, Duff HJ.

Circ Cardiovasc Genet. 2013 Aug;6(4):327-36. doi: 10.1161/CIRCGENETICS.113.000097. Epub 2013 Jul 17.

PMID:
23863954
[PubMed - indexed for MEDLINE]
Free Article
8.

Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.

Bai Y, Jones PP, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song LS, Duff HJ, Chen SR.

Circ Res. 2013 Aug 16;113(5):517-26. doi: 10.1161/CIRCRESAHA.113.301678. Epub 2013 Jul 15.

PMID:
23856523
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium.

Wang W, Wang X, Chun J, Vilaysane A, Clark S, French G, Bracey NA, Trpkov K, Bonni S, Duff HJ, Beck PL, Muruve DA.

J Immunol. 2013 Feb 1;190(3):1239-49. doi: 10.4049/jimmunol.1201959. Epub 2012 Dec 21.

PMID:
23264657
[PubMed - indexed for MEDLINE]
Free Article
10.

Auto-entrainment risk assessment in heart failure.

Roach DE, Morck ML, Sheldon RS, Duff HJ.

Circ Arrhythm Electrophysiol. 2013 Feb;6(1):129-36. doi: 10.1161/CIRCEP.112.971986. Epub 2012 Dec 22.

PMID:
23264372
[PubMed - indexed for MEDLINE]
Free Article
11.

Modeling of open, closed, and open-inactivated states of the hERG1 channel: structural mechanisms of the state-dependent drug binding.

Durdagi S, Deshpande S, Duff HJ, Noskov SY.

J Chem Inf Model. 2012 Oct 22;52(10):2760-74. doi: 10.1021/ci300353u. Epub 2012 Oct 2.

PMID:
22989185
[PubMed - indexed for MEDLINE]
12.

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.

Bracey NA, Beck PL, Muruve DA, Hirota SA, Guo J, Jabagi H, Wright JR Jr, Macdonald JA, Lees-Miller JP, Roach D, Semeniuk LM, Duff HJ.

Exp Physiol. 2013 Feb;98(2):462-72. doi: 10.1113/expphysiol.2012.068338. Epub 2012 Jul 30.

PMID:
22848083
[PubMed - indexed for MEDLINE]
Free Article
13.

Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.

Durdagi S, Guo J, Lees-Miller JP, Noskov SY, Duff HJ.

J Pharmacol Exp Ther. 2012 Aug;342(2):441-52. doi: 10.1124/jpet.111.189159. Epub 2012 May 9.

PMID:
22573844
[PubMed - indexed for MEDLINE]
Free Article
14.

Cell therapy limits myofibroblast differentiation and structural cardiac remodeling: basic fibroblast growth factor-mediated paracrine mechanism.

Fedak PW, Bai L, Turnbull J, Ngu J, Narine K, Duff HJ.

Circ Heart Fail. 2012 May 1;5(3):349-56. doi: 10.1161/CIRCHEARTFAILURE.111.965889. Epub 2012 Apr 16.

PMID:
22508775
[PubMed - indexed for MEDLINE]
Free Article
15.

Impact of stirred suspension bioreactor culture on the differentiation of murine embryonic stem cells into cardiomyocytes.

Shafa M, Krawetz R, Zhang Y, Rattner JB, Godollei A, Duff HJ, Rancourt DE.

BMC Cell Biol. 2011 Dec 14;12:53. doi: 10.1186/1471-2121-12-53.

PMID:
22168552
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.

Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song LS, Fill M, Back TG, Chen SR.

Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406.

PMID:
21743453
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Combined receptor and ligand-based approach to the universal pharmacophore model development for studies of drug blockade to the hERG1 pore domain.

Durdagi S, Duff HJ, Noskov SY.

J Chem Inf Model. 2011 Feb 28;51(2):463-74. doi: 10.1021/ci100409y. Epub 2011 Jan 11.

PMID:
21241063
[PubMed - indexed for MEDLINE]
18.

Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations.

Subbotina J, Yarov-Yarovoy V, Lees-Miller J, Durdagi S, Guo J, Duff HJ, Noskov SY.

Proteins. 2010 Nov 1;78(14):2922-34. doi: 10.1002/prot.22815.

PMID:
20740484
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Insights into the molecular mechanism of hERG1 channel activation and blockade by drugs.

Durdagi S, Subbotina J, Lees-Miller J, Guo J, Duff HJ, Noskov SY.

Curr Med Chem. 2010;17(30):3514-32. Review.

PMID:
20738248
[PubMed - indexed for MEDLINE]
20.

Impact of atrial antitachycardia pacing and atrial pace prevention therapies on atrial fibrillation burden over long-term follow-up.

Gillis AM, Morck M, Exner DV, Sheldon RS, Duff HJ, Mitchell BL, Wyse GD.

Europace. 2009 Aug;11(8):1041-7. doi: 10.1093/europace/eup115. Epub 2009 May 21.

PMID:
19460849
[PubMed - indexed for MEDLINE]
Free Article

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