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Items: 1 to 20 of 186


Dynamic Clamp: Insights From State-of-the-Art Experimentation.

Duff HJ.

Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1012-3. doi: 10.1161/CIRCEP.115.003298. No abstract available.


In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".

Lees-Miller JP, Guo J, Wang Y, Perissinotti LL, Noskov SY, Duff HJ.

J Mol Cell Cardiol. 2015 Oct;87:192-3. doi: 10.1016/j.yjmcc.2015.08.003. Epub 2015 Aug 20. No abstract available.


Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.

Lees-Miller JP, Guo J, Wang Y, Perissinotti LL, Noskov SY, Duff HJ.

J Mol Cell Cardiol. 2015 Aug;85:71-8. doi: 10.1016/j.yjmcc.2015.05.009. Epub 2015 May 16.


Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis.

Teng G, Svystonyuk D, Mewhort HE, Turnbull JD, Belke DD, Duff HJ, Fedak PW.

Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1564-74. doi: 10.1152/ajpheart.00126.2015. Epub 2015 Apr 10.


Ketones prevent oxidative impairment of hippocampal synaptic integrity through KATP channels.

Kim do Y, Abdelwahab MG, Lee SH, O'Neill D, Thompson RJ, Duff HJ, Sullivan PG, Rho JM.

PLoS One. 2015 Apr 7;10(4):e0119316. doi: 10.1371/journal.pone.0119316. eCollection 2015.


Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.

Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY.

Biophys J. 2015 Mar 24;108(6):1414-24. doi: 10.1016/j.bpj.2014.12.056.


NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.

Guo J, Cheng YM, Lees-Miller JP, Perissinotti LL, Claydon TW, Hull CM, Thouta S, Roach DE, Durdagi S, Noskov SY, Duff HJ.

Biophys J. 2015 Mar 24;108(6):1400-13. doi: 10.1016/j.bpj.2014.12.055.


Role of mutation and pharmacologic block of human KCNH2 in vasculogenesis and fetal mortality: partial rescue by transforming growth factor-β.

Teng G, Zhao X, Lees-Miller JP, Belke D, Shi C, Chen Y, O'Brien ER, Fedak PW, Bracey N, Cross JC, Duff HJ.

Circ Arrhythm Electrophysiol. 2015 Apr;8(2):420-8. doi: 10.1161/CIRCEP.114.001837. Epub 2015 Feb 3.


Phenotypic analysis of arrhythmogenic cardiomyopathy in the Hutterite population: role of electrocardiogram in identifying high-risk desmocollin-2 carriers.

Wong JA, Duff HJ, Yuen T, Kolman L, Exner DV, Weeks SG, Gerull B.

J Am Heart Assoc. 2014 Dec 11;3(6):e001407. doi: 10.1161/JAHA.114.001407.


Hierarchical regulation of wound healing by NOD-like receptors in cardiovascular disease.

Bracey NA, Duff HJ, Muruve DA.

Antioxid Redox Signal. 2015 May 1;22(13):1176-87. doi: 10.1089/ars.2014.6125. Epub 2014 Nov 10. Review.


Structure driven design of novel human ether-a-go-go-related-gene channel (hERG1) activators.

Guo J, Durdagi S, Changalov M, Perissinotti LL, Hargreaves JM, Back TG, Noskov SY, Duff HJ.

PLoS One. 2014 Sep 5;9(9):e105553. doi: 10.1371/journal.pone.0105553. eCollection 2014.


The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study.

Ezekowitz JA, Becher H, Belenkie I, Clark AM, Duff HJ, Friedrich MG, Haykowsky MJ, Howlett JG, Kassiri Z, Kaul P, Kim DH, Knudtson ML, Light PE, Lopaschuk GD, McAlister FA, Noga ML, Oudit GY, Paterson DI, Quan H, Schulz R, Thompson RB, Weeks SG, Anderson TJ, Dyck JR.

BMC Cardiovasc Disord. 2014 Jul 25;14:91. doi: 10.1186/1471-2261-14-91.


Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.

Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR Jr, Fedak PW, Beck PL, Muruve DA, Duff HJ.

J Biol Chem. 2014 Jul 11;289(28):19571-84. doi: 10.1074/jbc.M114.550624. Epub 2014 May 19.


Rehabilitating drug-induced long-QT promoters: in-silico design of hERG-neutral cisapride analogues with retained pharmacological activity.

Durdagi S, Randall T, Duff HJ, Chamberlin A, Noskov SY.

BMC Pharmacol Toxicol. 2014 Mar 8;15:14. doi: 10.1186/2050-6511-15-14.


Beyond doctrine and dogma: one gene--multisystem effects.

Duff HJ.

Circ Cardiovasc Genet. 2014 Feb;7(1):4. doi: 10.1161/CIRCGENETICS.114.000508. No abstract available.


The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.

Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR.

Nat Med. 2014 Feb;20(2):184-92. doi: 10.1038/nm.3440. Epub 2014 Jan 19.


Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.

Gerull B, Kirchner F, Chong JX, Tagoe J, Chandrasekharan K, Strohm O, Waggoner D, Ober C, Duff HJ.

Circ Cardiovasc Genet. 2013 Aug;6(4):327-36. doi: 10.1161/CIRCGENETICS.113.000097. Epub 2013 Jul 17.


Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.

Bai Y, Jones PP, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song LS, Duff HJ, Chen SR.

Circ Res. 2013 Aug 16;113(5):517-26. doi: 10.1161/CIRCRESAHA.113.301678. Epub 2013 Jul 15.


Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium.

Wang W, Wang X, Chun J, Vilaysane A, Clark S, French G, Bracey NA, Trpkov K, Bonni S, Duff HJ, Beck PL, Muruve DA.

J Immunol. 2013 Feb 1;190(3):1239-49. doi: 10.4049/jimmunol.1201959. Epub 2012 Dec 21.


Auto-entrainment risk assessment in heart failure.

Roach DE, Morck ML, Sheldon RS, Duff HJ.

Circ Arrhythm Electrophysiol. 2013 Feb;6(1):129-36. doi: 10.1161/CIRCEP.112.971986. Epub 2012 Dec 22.

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