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Targeting ETV1 in gastrointestinal stromal tumors: tripping the circuit breaker in GIST?

Duensing A.

Cancer Discov. 2015 Mar;5(3):231-3. doi: 10.1158/2159-8290.CD-15-0116.


The DREAM complex in antitumor activity of imatinib mesylate in gastrointestinal stromal tumors.

DeCaprio JA, Duensing A.

Curr Opin Oncol. 2014 Jul;26(4):415-21. doi: 10.1097/CCO.0000000000000090. Review.


Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors.

Boichuk S, Lee DJ, Mehalek KR, Makielski KR, Wozniak A, Seneviratne DS, Korzeniewski N, Cuevas R, Parry JA, Brown MF, Zewe J, Taguchi T, Kuan SF, Schöffski P, Debiec-Rychter M, Duensing A.

Cancer Res. 2014 Feb 15;74(4):1200-13. doi: 10.1158/0008-5472.CAN-13-1955. Epub 2014 Jan 2.


The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis.

Boichuk S, Parry JA, Makielski KR, Litovchick L, Baron JL, Zewe JP, Wozniak A, Mehalek KR, Korzeniewski N, Seneviratne DS, Schöffski P, Debiec-Rychter M, DeCaprio JA, Duensing A.

Cancer Res. 2013 Aug 15;73(16):5120-9. doi: 10.1158/0008-5472.CAN-13-0579. Epub 2013 Jun 20.


Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST].

Kelly L, Bryan K, Kim SY, Janeway KA, Killian JK, Schildhaus HU, Miettinen M, Helman L, Meltzer PS, van de Rijn M, Debiec-Rychter M, O'Sullivan M; NIH Pediatric and Wild-Type GIST Clinic.

PLoS One. 2013 May 24;8(5):e64102. doi: 10.1371/journal.pone.0064102. Print 2013.


Closing in on accurate risk prediction and disease management for patients with operable GIST.

Duensing A.

Lancet Oncol. 2012 Mar;13(3):220-1. doi: 10.1016/S1470-2045(11)70344-8. Epub 2011 Dec 6. No abstract available.


Tripeptidyl Peptidase II Is Required for c-MYC-Induced Centriole Overduplication and a Novel Therapeutic Target in c-MYC-Associated Neoplasms.

Duensing S, Darr S, Cuevas R, Melquiot N, Brickner AG, Duensing A, Münger K.

Genes Cancer. 2010 Sep;1(9):883-92. doi: 10.1177/1947601910389605.


Bortezomib: killing two birds with one stone in gastrointestinal stromal tumors.

Duensing S, Duensing A.

Oncotarget. 2010 May;1(1):6-8. Review. No abstract available.


Synergistic induction of apoptosis by the Bcl-2 inhibitor ABT-737 and imatinib mesylate in gastrointestinal stromal tumor cells.

Reynoso D, Nolden LK, Yang D, Dumont SN, Conley AP, Dumont AG, Zhou K, Duensing A, Trent JC.

Mol Oncol. 2011 Feb;5(1):93-104. doi: 10.1016/j.molonc.2010.10.003. Epub 2010 Oct 16.


Genomic instability and cancer: lessons learned from human papillomaviruses.

Korzeniewski N, Spardy N, Duensing A, Duensing S.

Cancer Lett. 2011 Jun 28;305(2):113-22. doi: 10.1016/j.canlet.2010.10.013. Epub 2010 Nov 13. Review.


Daughter centriole elongation is controlled by proteolysis.

Korzeniewski N, Cuevas R, Duensing A, Duensing S.

Mol Biol Cell. 2010 Nov 15;21(22):3942-51. doi: 10.1091/mbc.E09-12-1049. Epub 2010 Sep 22.


Centrosomes, polyploidy and cancer.

Duensing A, Duensing S.

Adv Exp Med Biol. 2010;676:93-103. Review.


A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention.

Korzeniewski N, Wheeler S, Chatterjee P, Duensing A, Duensing S.

Mol Cancer. 2010 Jun 17;9:153. doi: 10.1186/1476-4598-9-153.


Targeted therapies of gastrointestinal stromal tumors (GIST)--the next frontiers.

Duensing S, Duensing A.

Biochem Pharmacol. 2010 Sep 1;80(5):575-83. doi: 10.1016/j.bcp.2010.04.006. Epub 2010 Apr 10. Review.


Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells.

Bauer S, Parry JA, Mühlenberg T, Brown MF, Seneviratne D, Chatterjee P, Chin A, Rubin BP, Kuan SF, Fletcher JA, Duensing S, Duensing A.

Cancer Res. 2010 Jan 1;70(1):150-9. doi: 10.1158/0008-5472.CAN-09-1449. Epub 2009 Dec 22.


Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin.

Spardy N, Covella K, Cha E, Hoskins EE, Wells SI, Duensing A, Duensing S.

Cancer Res. 2009 Sep 1;69(17):7022-9. doi: 10.1158/0008-5472.CAN-09-0925. Epub 2009 Aug 25.


Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.

Korzeniewski N, Zheng L, Cuevas R, Parry J, Chatterjee P, Anderton B, Duensing A, Münger K, Duensing S.

Cancer Res. 2009 Aug 15;69(16):6668-75. doi: 10.1158/0008-5472.CAN-09-1284.


Centrosome overduplication, chromosomal instability, and human papillomavirus oncoproteins.

Duensing A, Spardy N, Chatterjee P, Zheng L, Parry J, Cuevas R, Korzeniewski N, Duensing S.

Environ Mol Mutagen. 2009 Oct;50(8):741-7. doi: 10.1002/em.20478. Review.


HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies.

Spardy N, Duensing A, Hoskins EE, Wells SI, Duensing S.

Cancer Res. 2008 Dec 1;68(23):9954-63. doi: 10.1158/0008-5472.CAN-08-0224.


Imatinib mesylate induces quiescence in gastrointestinal stromal tumor cells through the CDH1-SKP2-p27Kip1 signaling axis.

Liu Y, Perdreau SA, Chatterjee P, Wang L, Kuan SF, Duensing A.

Cancer Res. 2008 Nov 1;68(21):9015-23. doi: 10.1158/0008-5472.CAN-08-1935.

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