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Results: 1 to 20 of 42

1.

Overcoming obstacles to repurposing for neurodegenerative disease.

Shineman DW, Alam J, Anderson M, Black SE, Carman AJ, Cummings JL, Dacks PA, Dudley JT, Frail DE, Green A, Lane RF, Lappin D, Simuni T, Stefanacci RG, Sherer T, Fillit HM.

Ann Clin Transl Neurol. 2014 Jul;1(7):512-8. doi: 10.1002/acn3.76. Epub 2014 Jun 24.

PMID:
25356422
[PubMed]
Free PMC Article
2.

Disease risk factors identified through shared genetic architecture and electronic medical records.

Li L, Ruau DJ, Patel CJ, Weber SC, Chen R, Tatonetti NP, Dudley JT, Butte AJ.

Sci Transl Med. 2014 Apr 30;6(234):234ra57. doi: 10.1126/scitranslmed.3007191.

PMID:
24786325
[PubMed - in process]
3.

Automated detection of off-label drug use.

Jung K, LePendu P, Chen WS, Iyer SV, Readhead B, Dudley JT, Shah NH.

PLoS One. 2014 Feb 19;9(2):e89324. doi: 10.1371/journal.pone.0089324. eCollection 2014.

PMID:
24586689
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

STORMSeq: an open-source, user-friendly pipeline for processing personal genomics data in the cloud.

Karczewski KJ, Fernald GH, Martin AR, Snyder M, Tatonetti NP, Dudley JT.

PLoS One. 2014 Jan 15;9(1):e84860. doi: 10.1371/journal.pone.0084860. eCollection 2014.

PMID:
24454756
[PubMed - in process]
Free PMC Article
5.

Unifying immunology with informatics and multiscale biology.

Kidd BA, Peters LA, Schadt EE, Dudley JT.

Nat Immunol. 2014 Feb;15(2):118-27. doi: 10.1038/ni.2787. Review.

PMID:
24448569
[PubMed - indexed for MEDLINE]
6.

A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

Jahchan NS, Dudley JT, Mazur PK, Flores N, Yang D, Palmerton A, Zmoos AF, Vaka D, Tran KQ, Zhou M, Krasinska K, Riess JW, Neal JW, Khatri P, Park KS, Butte AJ, Sage J.

Cancer Discov. 2013 Dec;3(12):1364-77. doi: 10.1158/2159-8290.CD-13-0183. Epub 2013 Sep 26.

PMID:
24078773
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Systematic functional regulatory assessment of disease-associated variants.

Karczewski KJ, Dudley JT, Kukurba KR, Chen R, Butte AJ, Montgomery SB, Snyder M.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9607-12. doi: 10.1073/pnas.1219099110. Epub 2013 May 20.

PMID:
23690573
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Identification of cell surface targets through meta-analysis of microarray data.

Haeberle H, Dudley JT, Liu JT, Butte AJ, Contag CH.

Neoplasia. 2012 Jul;14(7):666-9.

PMID:
22904683
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Quantifying multi-ethnic representation in genetic studies of high mortality diseases.

Chen R, Dudley JT, Ruau D, Butte AJ.

AMIA Jt Summits Transl Sci Proc. 2012;2012:11-8. Epub 2012 Mar 19.

PMID:
22779041
[PubMed]
Free PMC Article
10.

Integrative approach to pain genetics identifies pain sensitivity loci across diseases.

Ruau D, Dudley JT, Chen R, Phillips NG, Swan GE, Lazzeroni LC, Clark JD, Butte AJ, Angst MS.

PLoS Comput Biol. 2012;8(6):e1002538. doi: 10.1371/journal.pcbi.1002538. Epub 2012 Jun 7.

PMID:
22685391
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Human genomic disease variants: a neutral evolutionary explanation.

Dudley JT, Kim Y, Liu L, Markov GJ, Gerold K, Chen R, Butte AJ, Kumar S.

Genome Res. 2012 Aug;22(8):1383-94. doi: 10.1101/gr.133702.111. Epub 2012 Jun 4. Review.

PMID:
22665443
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.

Chen R, Corona E, Sikora M, Dudley JT, Morgan AA, Moreno-Estrada A, Nilsen GB, Ruau D, Lincoln SE, Bustamante CD, Butte AJ.

PLoS Genet. 2012;8(4):e1002621. doi: 10.1371/journal.pgen.1002621. Epub 2012 Apr 12.

PMID:
22511877
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Personal omics profiling reveals dynamic molecular and medical phenotypes.

Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M.

Cell. 2012 Mar 16;148(6):1293-307. doi: 10.1016/j.cell.2012.02.009.

PMID:
22424236
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Evolutionary meta-analysis of association studies reveals ancient constraints affecting disease marker discovery.

Dudley JT, Chen R, Sanderford M, Butte AJ, Kumar S.

Mol Biol Evol. 2012 Sep;29(9):2087-94. doi: 10.1093/molbev/mss079. Epub 2012 Mar 1.

PMID:
22389448
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Interpretome: a freely available, modular, and secure personal genome interpretation engine.

Karczewski KJ, Tirrell RP, Cordero P, Tatonetti NP, Dudley JT, Salari K, Snyder M, Altman RB, Kim SK.

Pac Symp Biocomput. 2012:339-50.

PMID:
22174289
[PubMed - indexed for MEDLINE]
Free Article
16.

ProfileChaser: searching microarray repositories based on genome-wide patterns of differential expression.

Engreitz JM, Chen R, Morgan AA, Dudley JT, Mallelwar R, Butte AJ.

Bioinformatics. 2011 Dec 1;27(23):3317-8. doi: 10.1093/bioinformatics/btr548. Epub 2011 Oct 3.

PMID:
21967760
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Phased whole-genome genetic risk in a family quartet using a major allele reference sequence.

Dewey FE, Chen R, Cordero SP, Ormond KE, Caleshu C, Karczewski KJ, Whirl-Carrillo M, Wheeler MT, Dudley JT, Byrnes JK, Cornejo OE, Knowles JW, Woon M, Sangkuhl K, Gong L, Thorn CF, Hebert JM, Capriotti E, David SP, Pavlovic A, West A, Thakuria JV, Ball MP, Zaranek AW, Rehm HL, Church GM, West JS, Bustamante CD, Snyder M, Altman RB, Klein TE, Butte AJ, Ashley EA.

PLoS Genet. 2011 Sep;7(9):e1002280. doi: 10.1371/journal.pgen.1002280. Epub 2011 Sep 15.

PMID:
21935354
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Discovery and preclinical validation of drug indications using compendia of public gene expression data.

Sirota M, Dudley JT, Kim J, Chiang AP, Morgan AA, Sweet-Cordero A, Sage J, Butte AJ.

Sci Transl Med. 2011 Aug 17;3(96):96ra77. doi: 10.1126/scitranslmed.3001318. Erratum in: Sci Transl Med. 2011 Sep 28;3(102):102er7.

PMID:
21849665
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease.

Dudley JT, Sirota M, Shenoy M, Pai RK, Roedder S, Chiang AP, Morgan AA, Sarwal MM, Pasricha PJ, Butte AJ.

Sci Transl Med. 2011 Aug 17;3(96):96ra76. doi: 10.1126/scitranslmed.3002648.

PMID:
21849664
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations.

Kumar S, Dudley JT, Filipski A, Liu L.

Trends Genet. 2011 Sep;27(9):377-86. doi: 10.1016/j.tig.2011.06.004. Epub 2011 Jul 20. Review.

PMID:
21764165
[PubMed - indexed for MEDLINE]
Free PMC Article
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