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Age-stratified risk of unexpected uterine sarcoma following surgery for presumed benign leiomyoma.

Brohl AS, Li L, Andikyan V, Običan SG, Cioffi A, Hao K, Dudley JT, Ascher-Walsh C, Kasarskis A, Maki RG.

Oncologist. 2015 Apr;20(4):433-9. doi: 10.1634/theoncologist.2014-0361. Epub 2015 Mar 12.


Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders.

Björkegren JL, Kovacic JC, Dudley JT, Schadt EE.

J Am Coll Cardiol. 2015 Mar 3;65(8):830-45. doi: 10.1016/j.jacc.2014.12.033. Review.


Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions.

Xu K, Schadt EE, Pollard KS, Roussos P, Dudley JT.

Mol Biol Evol. 2015 May;32(5):1148-60. doi: 10.1093/molbev/msv031. Epub 2015 Feb 12.


A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer.

Vidal SJ, Rodriguez-Bravo V, Quinn SA, Rodriguez-Barrueco R, Lujambio A, Williams E, Sun X, de la Iglesia-Vicente J, Lee A, Readhead B, Chen X, Galsky M, Esteve B, Petrylak DP, Dudley JT, Rabadan R, Silva JM, Hoshida Y, Lowe SW, Cordon-Cardo C, Domingo-Domenech J.

Cancer Cell. 2015 Feb 9;27(2):223-39. doi: 10.1016/j.ccell.2014.11.013.


An integrative pipeline for multi-modal discovery of disease relationships.

Glicksberg BS, Li L, Cheng WY, Shameer K, Hakenberg J, Castellanos R, Ma M, Shi L, Shah H, Dudley JT, Chen R.

Pac Symp Biocomput. 2015:407-18.


Personalized medicine: from genotypes, molecular phenotypes and the quantified self, towards improved medicine.

Dudley JT, Listgarten J, Stegle O, Brenner SE, Parts L.

Pac Symp Biocomput. 2015:342-6.


Computational and experimental advances in drug repositioning for accelerated therapeutic stratification.

Shameer K, Readhead B, Dudley JT.

Curr Top Med Chem. 2015;15(1):5-20.


REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids.

Baida G, Bhalla P, Kirsanov K, Lesovaya E, Yakubovskaya M, Yuen K, Guo S, Lavker RM, Readhead B, Dudley JT, Budunova I.

EMBO Mol Med. 2014 Dec 11;7(1):42-58. doi: 10.15252/emmm.201404601.


Overcoming obstacles to repurposing for neurodegenerative disease.

Shineman DW, Alam J, Anderson M, Black SE, Carman AJ, Cummings JL, Dacks PA, Dudley JT, Frail DE, Green A, Lane RF, Lappin D, Simuni T, Stefanacci RG, Sherer T, Fillit HM.

Ann Clin Transl Neurol. 2014 Jul;1(7):512-8. doi: 10.1002/acn3.76. Epub 2014 Jun 24.


Disease risk factors identified through shared genetic architecture and electronic medical records.

Li L, Ruau DJ, Patel CJ, Weber SC, Chen R, Tatonetti NP, Dudley JT, Butte AJ.

Sci Transl Med. 2014 Apr 30;6(234):234ra57. doi: 10.1126/scitranslmed.3007191.


Automated detection of off-label drug use.

Jung K, LePendu P, Chen WS, Iyer SV, Readhead B, Dudley JT, Shah NH.

PLoS One. 2014 Feb 19;9(2):e89324. doi: 10.1371/journal.pone.0089324. eCollection 2014.


STORMSeq: an open-source, user-friendly pipeline for processing personal genomics data in the cloud.

Karczewski KJ, Fernald GH, Martin AR, Snyder M, Tatonetti NP, Dudley JT.

PLoS One. 2014 Jan 15;9(1):e84860. doi: 10.1371/journal.pone.0084860. eCollection 2014.


Unifying immunology with informatics and multiscale biology.

Kidd BA, Peters LA, Schadt EE, Dudley JT.

Nat Immunol. 2014 Feb;15(2):118-27. doi: 10.1038/ni.2787. Review. Erratum in: Nat Immunol. 2014 Sep;15(9):894.


A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

Jahchan NS, Dudley JT, Mazur PK, Flores N, Yang D, Palmerton A, Zmoos AF, Vaka D, Tran KQ, Zhou M, Krasinska K, Riess JW, Neal JW, Khatri P, Park KS, Butte AJ, Sage J.

Cancer Discov. 2013 Dec;3(12):1364-77. doi: 10.1158/2159-8290.CD-13-0183. Epub 2013 Sep 26.


Systematic functional regulatory assessment of disease-associated variants.

Karczewski KJ, Dudley JT, Kukurba KR, Chen R, Butte AJ, Montgomery SB, Snyder M.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9607-12. doi: 10.1073/pnas.1219099110. Epub 2013 May 20.


Identification of cell surface targets through meta-analysis of microarray data.

Haeberle H, Dudley JT, Liu JT, Butte AJ, Contag CH.

Neoplasia. 2012 Jul;14(7):666-9.


Quantifying multi-ethnic representation in genetic studies of high mortality diseases.

Chen R, Dudley JT, Ruau D, Butte AJ.

AMIA Jt Summits Transl Sci Proc. 2012;2012:11-8. Epub 2012 Mar 19.


Integrative approach to pain genetics identifies pain sensitivity loci across diseases.

Ruau D, Dudley JT, Chen R, Phillips NG, Swan GE, Lazzeroni LC, Clark JD, Butte AJ, Angst MS.

PLoS Comput Biol. 2012;8(6):e1002538. doi: 10.1371/journal.pcbi.1002538. Epub 2012 Jun 7.


Human genomic disease variants: a neutral evolutionary explanation.

Dudley JT, Kim Y, Liu L, Markov GJ, Gerold K, Chen R, Butte AJ, Kumar S.

Genome Res. 2012 Aug;22(8):1383-94. doi: 10.1101/gr.133702.111. Epub 2012 Jun 4. Review.


Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.

Chen R, Corona E, Sikora M, Dudley JT, Morgan AA, Moreno-Estrada A, Nilsen GB, Ruau D, Lincoln SE, Bustamante CD, Butte AJ.

PLoS Genet. 2012;8(4):e1002621. doi: 10.1371/journal.pgen.1002621. Epub 2012 Apr 12.

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