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Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.
Wu H, D'Alessio AC, Ito S, Xia K, Wang Z, Cui K, Zhao K, Sun YE, Zhang Y. Wu H, et al. Nature. 2011 May 19;473(7347):389-93. doi: 10.1038/nature09934. Epub 2011 Mar 30. Nature. 2011. PMID: 21451524 Free PMC article.
Using chromatin immunoprecipitation coupled with high-throughput DNA sequencing, here we show in mouse ES cells that Tet1 is preferentially bound to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. ...Thus, our st …
Using chromatin immunoprecipitation coupled with high-throughput DNA sequencing, here we show in mouse ES cells that Tet1 …
TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells.
de la Rica L, Deniz Ö, Cheng KC, Todd CD, Cruz C, Houseley J, Branco MR. de la Rica L, et al. Genome Biol. 2016 Nov 18;17(1):234. doi: 10.1186/s13059-016-1096-8. Genome Biol. 2016. PMID: 27863519 Free PMC article.
Despite extensive research into the role of TETs in genome regulation, little is known about their effect on transposable elements (TEs), which make up nearly half of the mouse and human genomes. ...RESULTS: We performed a detailed investigation of the role of TET e …
Despite extensive research into the role of TETs in genome regulation, little is known about their effect on transposable elements (T …
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.
Wu H, D'Alessio AC, Ito S, Wang Z, Cui K, Zhao K, Sun YE, Zhang Y. Wu H, et al. Genes Dev. 2011 Apr 1;25(7):679-84. doi: 10.1101/gad.2036011. Genes Dev. 2011. PMID: 21460036 Free PMC article.
While 5mC has been studied extensively, little is known about the distribution and function of 5hmC. Here we present a genome-wide profile of 5hmC in mouse embryonic stem (ES) cells. ...Thus, our study reveals the first genome-wide 5hmC distribu …
While 5mC has been studied extensively, little is known about the distribution and function of 5hmC. Here we present a genome-wide pr …
Oct4 and the small molecule inhibitor, SC1, regulates Tet2 expression in mouse embryonic stem cells.
Wu Y, Guo Z, Liu Y, Tang B, Wang Y, Yang L, Du J, Zhang Y. Wu Y, et al. Mol Biol Rep. 2013 Apr;40(4):2897-906. doi: 10.1007/s11033-012-2305-5. Epub 2012 Dec 20. Mol Biol Rep. 2013. PMID: 23254757
Tet1 and Tet2 are highly expressed in undifferentiated embryonic stem cells (ESCs), and this expression decreases upon differentiation. ...Here we report that the pluripotency transcription factor, Oct4, directly regulates the expression …
Tet1 and Tet2 are highly expressed in undifferentiated embryonic stem cells (ESCs), and this expression decrease …