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Items: 1 to 20 of 45


Sensory and autonomic deficits in a new humanized mouse model of familial dysautonomia.

Morini E, Dietrich P, Salani M, Downs HM, Wojtkiewicz GR, Alli S, Brenner A, Nilbratt M, LeClair JW, Oaklander AL, Slaugenhaupt SA, Dragatsis I.

Hum Mol Genet. 2016 Mar 15;25(6):1116-28. doi: 10.1093/hmg/ddv634. Epub 2016 Jan 13.


Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice.

Mir H, Meena AS, Chaudhry KK, Shukla PK, Gangwar R, Manda B, Padala MK, Shen L, Turner JR, Dietrich P, Dragatsis I, Rao R.

Biochim Biophys Acta. 2016 Apr;1860(4):765-74. doi: 10.1016/j.bbagen.2015.12.013. Epub 2015 Dec 23.


ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice.

Chaudhry KK, Samak G, Shukla PK, Mir H, Gangwar R, Manda B, Isse T, Kawamoto T, Salaspuro M, Kaihovaara P, Dietrich P, Dragatsis I, Nagy LE, Rao RK.

Alcohol Clin Exp Res. 2015 Aug;39(8):1465-75. doi: 10.1111/acer.12777. Epub 2015 Jul 14.


HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta.

Smeyne M, Sladen P, Jiao Y, Dragatsis I, Smeyne RJ.

Neuroscience. 2015 Jun 4;295:23-38. doi: 10.1016/j.neuroscience.2015.03.015. Epub 2015 Mar 19.


Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.

McKinstry SU, Karadeniz YB, Worthington AK, Hayrapetyan VY, Ozlu MI, Serafin-Molina K, Risher WC, Ustunkaya T, Dragatsis I, Zeitlin S, Yin HH, Eroglu C.

J Neurosci. 2014 Jul 9;34(28):9455-72. doi: 10.1523/JNEUROSCI.4699-13.2014.


IKAP deficiency in an FD mouse model and in oligodendrocyte precursor cells results in downregulation of genes involved in oligodendrocyte differentiation and myelin formation.

Cheishvili D, Dietrich P, Maayan C, Even A, Weil M, Dragatsis I, Razin A.

PLoS One. 2014 Apr 23;9(4):e94612. doi: 10.1371/journal.pone.0094612. eCollection 2014.


Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses.

Archambault AS, Carrero JA, Barnett LG, McGee NG, Sim J, Wright JO, Raabe T, Chen P, Ding H, Allenspach EJ, Dragatsis I, Laufer TM, Wu GF.

J Immunol. 2013 Jul 15;191(2):545-50. doi: 10.4049/jimmunol.1201598. Epub 2013 Jun 14.


IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia.

Dietrich P, Alli S, Shanmugasundaram R, Dragatsis I.

Hum Mol Genet. 2012 Dec 1;21(23):5078-90. doi: 10.1093/hmg/dds354. Epub 2012 Aug 24.


Deletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality.

Dietrich P, Yue J, E S, Dragatsis I.

PLoS One. 2011;6(10):e27015. doi: 10.1371/journal.pone.0027015. Epub 2011 Oct 28.


Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.

Keryer G, Pineda JR, Liot G, Kim J, Dietrich P, Benstaali C, Smith K, Cordelières FP, Spassky N, Ferrante RJ, Dragatsis I, Saudou F.

J Clin Invest. 2011 Nov;121(11):4372-82. doi: 10.1172/JCI57552. Epub 2011 Oct 10.


Genetics and neuropathology of Huntington's disease.

Reiner A, Dragatsis I, Dietrich P.

Int Rev Neurobiol. 2011;98:325-72. doi: 10.1016/B978-0-12-381328-2.00014-6. Review.


Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis.

Godin JD, Colombo K, Molina-Calavita M, Keryer G, Zala D, Charrin BC, Dietrich P, Volvert ML, Guillemot F, Dragatsis I, Bellaiche Y, Saudou F, Nguyen L, Humbert S.

Neuron. 2010 Aug 12;67(3):392-406. doi: 10.1016/j.neuron.2010.06.027.


α8-integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning.

Chan CS, Chen H, Bradley A, Dragatsis I, Rosenmund C, Davis RL.

Genes Brain Behav. 2010 Jun 1;9(4):402-10. doi: 10.1111/j.1601-183X.2010.00569.x. Epub 2010 Jan 30.


Presenilins are essential for regulating neurotransmitter release.

Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J.

Nature. 2009 Jul 30;460(7255):632-6. doi: 10.1038/nature08177.


The hormonal action of IGF1 in postnatal mouse growth.

Stratikopoulos E, Szabolcs M, Dragatsis I, Klinakis A, Efstratiadis A.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19378-83. doi: 10.1073/pnas.0809223105. Epub 2008 Nov 25.


CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse.

Dragatsis I, Goldowitz D, Del Mar N, Deng YP, Meade CA, Liu L, Sun Z, Dietrich P, Yue J, Reiner A.

Neurobiol Dis. 2009 Mar;33(3):315-30. doi: 10.1016/j.nbd.2008.10.009. Epub 2008 Nov 6.


Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages.

Dietrich P, Shanmugasundaram R, Shuyu E, Dragatsis I.

Hum Mol Genet. 2009 Jan 1;18(1):142-50. doi: 10.1093/hmg/ddn324. Epub 2008 Oct 6.


Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts.

Zhang H, Das S, Li QZ, Dragatsis I, Repa J, Zeitlin S, Hajnóczky G, Bezprozvanny I.

BMC Neurosci. 2008 Apr 15;9:38. doi: 10.1186/1471-2202-9-38.


A transgenic mouse class-III beta tubulin reporter using yellow fluorescent protein.

Liu L, Geisert EE, Frankfurter A, Spano AJ, Jiang CX, Yue J, Dragatsis I, Goldowitz D.

Genesis. 2007 Sep;45(9):560-9.


Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia.

Baranova O, Miranda LF, Pichiule P, Dragatsis I, Johnson RS, Chavez JC.

J Neurosci. 2007 Jun 6;27(23):6320-32.

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