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Results: 1 to 20 of 187

1.

Expanding the Biologist's Toolkit with CRISPR-Cas9.

Sternberg SH, Doudna JA.

Mol Cell. 2015 May 21;58(4):568-574. doi: 10.1016/j.molcel.2015.02.032. Review.

PMID:
26000842
2.

Structural biology. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning.

Taylor DW, Zhu Y, Staals RH, Kornfeld JE, Shinkai A, van der Oost J, Nogales E, Doudna JA.

Science. 2015 May 1;348(6234):581-5. doi: 10.1126/science.aaa4535. Epub 2015 Apr 2.

PMID:
25837515
3.

Biotechnology. A prudent path forward for genomic engineering and germline gene modification.

Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR.

Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19. No abstract available.

PMID:
25791083
4.

The structural biology of CRISPR-Cas systems.

Jiang F, Doudna JA.

Curr Opin Struct Biol. 2015 Feb;30:100-111. doi: 10.1016/j.sbi.2015.02.002. Epub 2015 Feb 24. Review.

PMID:
25723899
5.

Rational design of a split-Cas9 enzyme complex.

Wright AV, Sternberg SH, Taylor DW, Staahl BT, Bardales JA, Kornfeld JE, Doudna JA.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):2984-9. doi: 10.1073/pnas.1501698112. Epub 2015 Feb 23.

6.

Genomic engineering and the future of medicine.

Doudna JA.

JAMA. 2015 Feb 24;313(8):791-2. doi: 10.1001/jama.2015.287. No abstract available.

PMID:
25710652
7.

Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity.

Nuñez JK, Lee AS, Engelman A, Doudna JA.

Nature. 2015 Mar 12;519(7542):193-8. doi: 10.1038/nature14237. Epub 2015 Feb 18.

PMID:
25707795
8.

Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis.

Wilson RC, Tambe A, Kidwell MA, Noland CL, Schneider CP, Doudna JA.

Mol Cell. 2015 Feb 5;57(3):397-407. doi: 10.1016/j.molcel.2014.11.030. Epub 2014 Dec 31.

PMID:
25557550
9.

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery.

Lin S, Staahl BT, Alla RK, Doudna JA.

Elife. 2014 Dec 15;3:e04766. doi: 10.7554/eLife.04766.

10.

Cutting it close: CRISPR-associated endoribonuclease structure and function.

Hochstrasser ML, Doudna JA.

Trends Biochem Sci. 2015 Jan;40(1):58-66. doi: 10.1016/j.tibs.2014.10.007. Epub 2014 Nov 18.

PMID:
25468820
11.

RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus.

Staals RH, Zhu Y, Taylor DW, Kornfeld JE, Sharma K, Barendregt A, Koehorst JJ, Vlot M, Neupane N, Varossieau K, Sakamoto K, Suzuki T, Dohmae N, Yokoyama S, Schaap PJ, Urlaub H, Heck AJ, Nogales E, Doudna JA, Shinkai A, van der Oost J.

Mol Cell. 2014 Nov 20;56(4):518-30. doi: 10.1016/j.molcel.2014.10.005. Epub 2014 Nov 6.

PMID:
25457165
12.

Genome editing. The new frontier of genome engineering with CRISPR-Cas9.

Doudna JA, Charpentier E.

Science. 2014 Nov 28;346(6213):1258096. doi: 10.1126/science.1258096. Review.

PMID:
25430774
13.

Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface.

Doudna JA, Sontheimer EJ.

Methods Enzymol. 2014;546:xix-xx. doi: 10.1016/B978-0-12-801185-0.09983-9. No abstract available.

PMID:
25398356
14.

New tools provide a second look at HDV ribozyme structure, dynamics and cleavage.

Kapral GJ, Jain S, Noeske J, Doudna JA, Richardson DC, Richardson JS.

Nucleic Acids Res. 2014 Nov 10;42(20):12833-46. doi: 10.1093/nar/gku992. Epub 2014 Oct 17.

15.

Programmable RNA recognition and cleavage by CRISPR/Cas9.

O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA.

Nature. 2014 Dec 11;516(7530):263-6. doi: 10.1038/nature13769. Epub 2014 Sep 28.

PMID:
25274302
16.

RNA-guided assembly of Rev-RRE nuclear export complexes.

Bai Y, Tambe A, Zhou K, Doudna JA.

Elife. 2014 Aug 27;3:e03656. doi: 10.7554/eLife.03656.

17.

Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing.

Kidwell MA, Chan JM, Doudna JA.

J Biol Chem. 2014 Oct 10;289(41):28352-62. doi: 10.1074/jbc.M114.589051. Epub 2014 Aug 18.

PMID:
25135636
18.

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.

Kranzusch PJ, Lee AS, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA.

Cell. 2014 Aug 28;158(5):1011-21. doi: 10.1016/j.cell.2014.07.028. Epub 2014 Aug 14.

PMID:
25131990
19.

Insights into RNA structure and function from genome-wide studies.

Mortimer SA, Kidwell MA, Doudna JA.

Nat Rev Genet. 2014 Jul;15(7):469-79. doi: 10.1038/nrg3681. Epub 2014 May 13. Review.

PMID:
24821474
20.

Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity.

Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA.

Nat Struct Mol Biol. 2014 Jun;21(6):528-34. doi: 10.1038/nsmb.2820. Epub 2014 May 4.

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