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Results: 1 to 20 of 169

1.

Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma.

Allen-Rhoades W, Kurenbekova L, Satterfield L, Parikh N, Fuja D, Shuck RL, Rainusso N, Trucco M, Barkauskas DA, Jo E, Ahern C, Hilsenbeck S, Donehower LA, Yustein JT.

Cancer Med. 2015 Mar 17. doi: 10.1002/cam4.438. [Epub ahead of print]

2.

WIP1 phosphatase as a potential therapeutic target in neuroblastoma.

Richter M, Dayaram T, Gilmartin AG, Ganji G, Pemmasani SK, Van Der Key H, Shohet JM, Donehower LA, Kumar R.

PLoS One. 2015 Feb 6;10(2):e0115635. doi: 10.1371/journal.pone.0115635. eCollection 2015.

3.

NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma.

Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, Jones SN, Lazar AJ, Ingram D, Lev D, Donehower LA, Yustein JT.

Oncogene. 2015 Jan 12. doi: 10.1038/onc.2014.429. [Epub ahead of print]

PMID:
25579177
4.

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.

Xia Z, Donehower LA, Cooper TA, Neilson JR, Wheeler DA, Wagner EJ, Li W.

Nat Commun. 2014 Nov 20;5:5274. doi: 10.1038/ncomms6274.

PMID:
25409906
5.

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.

Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, Tsuji S, Donehower LA, Slagle BL, Nakamura H, Yamamoto S, Shinbrot E, Hama N, Lehmkuhl M, Hosoda F, Arai Y, Walker K, Dahdouli M, Gotoh K, Nagae G, Gingras MC, Muzny DM, Ojima H, Shimada K, Midorikawa Y, Goss JA, Cotton R, Hayashi A, Shibahara J, Ishikawa S, Guiteau J, Tanaka M, Urushidate T, Ohashi S, Okada N, Doddapaneni H, Wang M, Zhu Y, Dinh H, Okusaka T, Kokudo N, Kosuge T, Takayama T, Fukayama M, Gibbs RA, Wheeler DA, Aburatani H, Shibata T.

Nat Genet. 2014 Dec;46(12):1267-73. doi: 10.1038/ng.3126. Epub 2014 Nov 2.

PMID:
25362482
6.

Notch activation as a driver of osteogenic sarcoma.

Tao J, Jiang MM, Jiang L, Salvo JS, Zeng HC, Dawson B, Bertin TK, Rao PH, Chen R, Donehower LA, Gannon F, Lee BH.

Cancer Cell. 2014 Sep 8;26(3):390-401. doi: 10.1016/j.ccr.2014.07.023.

PMID:
25203324
7.

The somatic genomic landscape of chromophobe renal cell carcinoma.

Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, Biehl M, Seth S, Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P, Reuter V, Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA; Cancer Genome Atlas Research Network, Chin L, Meyerson M, Kucherlapati R, Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M, Shuch B, Muzny D, Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, Creighton CJ.

Cancer Cell. 2014 Sep 8;26(3):319-30. doi: 10.1016/j.ccr.2014.07.014. Epub 2014 Aug 21.

PMID:
25155756
8.

Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.

Xiong S, Tu H, Kollareddy M, Pant V, Li Q, Zhang Y, Jackson JG, Suh YA, Elizondo-Fraire AC, Yang P, Chau G, Tashakori M, Wasylishen AR, Ju Z, Solomon H, Rotter V, Liu B, El-Naggar AK, Donehower LA, Martinez LA, Lozano G.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11145-50. doi: 10.1073/pnas.1404139111. Epub 2014 Jul 14.

9.

Phosphatases reverse p53-mediated cell cycle checkpoints.

Donehower LA.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7172-3. doi: 10.1073/pnas.1405663111. Epub 2014 May 7. No abstract available.

10.

Combinatorial therapy discovery using mixed integer linear programming.

Pang K, Wan YW, Choi WT, Donehower LA, Sun J, Pant D, Liu Z.

Bioinformatics. 2014 May 15;30(10):1456-63. doi: 10.1093/bioinformatics/btu046. Epub 2014 Jan 24.

PMID:
24463180
11.

Insights into wild-type and mutant p53 functions provided by genetically engineered mice.

Donehower LA.

Hum Mutat. 2014 Jun;35(6):715-27. doi: 10.1002/humu.22507. Epub 2014 Feb 5.

PMID:
24415648
12.

Effects of TP53 mutational status on gene expression patterns across 10 human cancer types.

Parikh N, Hilsenbeck S, Creighton CJ, Dayaram T, Shuck R, Shinbrot E, Xi L, Gibbs RA, Wheeler DA, Donehower LA.

J Pathol. 2014 Apr;232(5):522-33. doi: 10.1002/path.4321. Epub 2014 Jan 29.

13.

REG╬│ deficiency promotes premature aging via the casein kinase 1 pathway.

Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J, O'Malley BW, Li X.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11005-10. doi: 10.1073/pnas.1308497110. Epub 2013 Jun 13.

14.

Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage.

Dayaram T, Lemoine FJ, Donehower LA, Marriott SJ.

PLoS One. 2013;8(2):e55989. doi: 10.1371/journal.pone.0055989. Epub 2013 Feb 6.

15.
16.

Comprehensive molecular portraits of human breast tumours.

Cancer Genome Atlas Network.

Nature. 2012 Oct 4;490(7418):61-70. doi: 10.1038/nature11412. Epub 2012 Sep 23.

17.

MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.

Donehower LA, Creighton CJ, Schultz N, Shinbrot E, Chang K, Gunaratne PH, Muzny D, Sander C, Hamilton SR, Gibbs RA, Wheeler D.

J Pathol. 2013 Jan;229(1):99-110. doi: 10.1002/path.4087.

18.

Comprehensive molecular characterization of human colon and rectal cancer.

Cancer Genome Atlas Network.

Nature. 2012 Jul 18;487(7407):330-7. doi: 10.1038/nature11252.

19.

Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.

Parikh N, Shuck RL, Nguyen TA, Herron A, Donehower LA.

Mol Cancer Res. 2012 Jun;10(6):845-55. doi: 10.1158/1541-7786.MCR-12-0089. Epub 2012 Apr 24.

20.

Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.

Darlington Y, Nguyen TA, Moon SH, Herron A, Rao P, Zhu C, Lu X, Donehower LA.

Oncogene. 2012 Mar 1;31(9):1155-65. doi: 10.1038/onc.2011.303. Epub 2011 Jul 18.

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