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Items: 1 to 20 of 188

1.

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis.

Proctor EA, Fee L, Tao Y, Redler RL, Fay JM, Zhang Y, Lv Z, Mercer IP, Deshmukh M, Lyubchenko YL, Dokholyan NV.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):614-9. doi: 10.1073/pnas.1516725113. Epub 2015 Dec 30.

PMID:
26719414
2.

Gain-of-function mutation W493R in the epithelial sodium channel allosterically reconfigures intersubunit coupling.

Shobair M, Dagliyan O, Kota P, Dang YL, He H, Stutts MJ, Dokholyan NV.

J Biol Chem. 2015 Dec 14. pii: jbc.M115.678052. [Epub ahead of print]

3.

Structural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signaling.

Samoshkin A, Convertino M, Viet CT, Wieskopf JS, Kambur O, Marcovitz J, Patel P, Stone LS, Kalso E, Mogil JS, Schmidt BL, Maixner W, Dokholyan NV, Diatchenko L.

Sci Rep. 2015 Dec 11;5:18198. doi: 10.1038/srep18198.

4.

Applications of Discrete Molecular Dynamics in biology and medicine.

Proctor EA, Dokholyan NV.

Curr Opin Struct Biol. 2015 Nov 27;37:9-13. doi: 10.1016/j.sbi.2015.11.001. [Epub ahead of print] Review.

PMID:
26638022
5.

Protein Destabilization as a Common Factor in Diverse Inherited Disorders.

Redler RL, Das J, Diaz JR, Dokholyan NV.

J Mol Evol. 2016 Jan;82(1):11-6. doi: 10.1007/s00239-015-9717-5. Epub 2015 Nov 19.

PMID:
26584803
6.

Dynamic Docking of Conformationally Constrained Macrocycles: Methods and Applications.

Allen SE, Dokholyan NV, Bowers AA.

ACS Chem Biol. 2016 Jan 15;11(1):10-24. doi: 10.1021/acschembio.5b00663. Epub 2015 Dec 4.

PMID:
26575401
7.

Differential Regulation of 6- and 7-Transmembrane Helix Variants of μ-Opioid Receptor in Response to Morphine Stimulation.

Convertino M, Samoshkin A, Viet CT, Gauthier J, Li Fraine SP, Sharif-Naeini R, Schmidt BL, Maixner W, Diatchenko L, Dokholyan NV.

PLoS One. 2015 Nov 10;10(11):e0142826. doi: 10.1371/journal.pone.0142826. eCollection 2015.

8.

ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.

Williams B 2nd, Convertino M, Das J, Dokholyan NV.

PLoS Comput Biol. 2015 Oct 27;11(10):e1004359. doi: 10.1371/journal.pcbi.1004359. eCollection 2015 Oct.

9.

Differences in the Antinociceptive Effects and Binding Properties of Propranolol and Bupranolol Enantiomers.

Martin LJ, Piltonen MH, Gauthier J, Convertino M, Acland EL, Dokholyan NV, Mogil JS, Diatchenko L, Maixner W.

J Pain. 2015 Dec;16(12):1321-33. doi: 10.1016/j.jpain.2015.09.004. Epub 2015 Oct 9.

PMID:
26456674
10.

COMT gene locus: new functional variants.

Meloto CB, Segall SK, Smith S, Parisien M, Shabalina SA, Rizzatti-Barbosa CM, Gauthier J, Tsao D, Convertino M, Piltonen MH, Slade GD, Fillingim RB, Greenspan JD, Ohrbach R, Knott C, Maixner W, Zaykin D, Dokholyan NV, Reenilä I, Männistö PT, Diatchenko L.

Pain. 2015 Oct;156(10):2072-83. doi: 10.1097/j.pain.0000000000000273.

PMID:
26207649
11.

Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX.

Wang L, Xie L, Ramachandran S, Lee Y, Yan Z, Zhou L, Krajewski K, Liu F, Zhu C, Chen DJ, Strahl BD, Jin J, Dokholyan NV, Chen X.

Chem Biol. 2015 Jul 23;22(7):849-61. doi: 10.1016/j.chembiol.2015.05.014. Epub 2015 Jun 25.

PMID:
26119999
12.

Channel Gating Dependence on Pore Lining Helix Glycine Residues in Skeletal Muscle Ryanodine Receptor.

Mei Y, Xu L, Mowrey DD, Mendez Giraldez R, Wang Y, Pasek DA, Dokholyan NV, Meissner G.

J Biol Chem. 2015 Jul 10;290(28):17535-45. doi: 10.1074/jbc.M115.659672. Epub 2015 May 21.

PMID:
25998124
13.

iFoldRNA v2: folding RNA with constraints.

Krokhotin A, Houlihan K, Dokholyan NV.

Bioinformatics. 2015 Sep 1;31(17):2891-3. doi: 10.1093/bioinformatics/btv221. Epub 2015 Apr 24.

PMID:
25910700
14.

RNA-Puzzles Round II: assessment of RNA structure prediction programs applied to three large RNA structures.

Miao Z, Adamiak RW, Blanchet MF, Boniecki M, Bujnicki JM, Chen SJ, Cheng C, Chojnowski G, Chou FC, Cordero P, Cruz JA, Ferré-D'Amaré AR, Das R, Ding F, Dokholyan NV, Dunin-Horkawicz S, Kladwang W, Krokhotin A, Lach G, Magnus M, Major F, Mann TH, Masquida B, Matelska D, Meyer M, Peselis A, Popenda M, Purzycka KJ, Serganov A, Stasiewicz J, Szachniuk M, Tandon A, Tian S, Wang J, Xiao Y, Xu X, Zhang J, Zhao P, Zok T, Westhof E.

RNA. 2015 Jun;21(6):1066-84. doi: 10.1261/rna.049502.114. Epub 2015 Apr 16.

15.

Computational methods toward accurate RNA structure prediction using coarse-grained and all-atom models.

Krokhotin A, Dokholyan NV.

Methods Enzymol. 2015;553:65-89. doi: 10.1016/bs.mie.2014.10.052. Epub 2015 Feb 3.

PMID:
25726461
16.

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization.

Brown KA, Zou Y, Shirvanyants D, Zhang J, Samanta S, Mantravadi PK, Dokholyan NV, Deiters A.

Chem Commun (Camb). 2015 Apr 4;51(26):5702-5. doi: 10.1039/c4cc09442e.

PMID:
25716548
17.

Rational Coupled Dynamics Network Manipulation Rescues Disease-Relevant Mutant Cystic Fibrosis Transmembrane Conductance Regulator.

Proctor EA, Kota P, Aleksandrov AA, He L, Riordan JR, Dokholyan NV.

Chem Sci. 2015 Feb;6(2):1237-1246.

18.

μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids.

Convertino M, Samoshkin A, Gauthier J, Gold MS, Maixner W, Dokholyan NV, Diatchenko L.

Prog Neuropsychopharmacol Biol Psychiatry. 2015 Oct 1;62:61-7. doi: 10.1016/j.pnpbp.2014.11.009. Epub 2014 Dec 6.

PMID:
25485963
19.

RNA tertiary structure analysis by 2'-hydroxyl molecular interference.

Homan PJ, Tandon A, Rice GM, Ding F, Dokholyan NV, Weeks KM.

Biochemistry. 2014 Nov 4;53(43):6825-33. doi: 10.1021/bi501218g. Epub 2014 Oct 23.

PMID:
25341083
20.

Traffic within the cytochrome b6f lipoprotein complex: gating of the quinone portal.

Hasan SS, Proctor EA, Yamashita E, Dokholyan NV, Cramer WA.

Biophys J. 2014 Oct 7;107(7):1620-8. doi: 10.1016/j.bpj.2014.08.003.

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