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Sizing up the key determinants of the CD8+ T cell response.

Tscharke DC, Croft NP, Doherty PC, La Gruta NL.

Nat Rev Immunol. 2015 Oct 9. doi: 10.1038/nri3905. [Epub ahead of print]


Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8⁺ T cells.

Wang Z, Wan Y, Qiu C, Quiñones-Parra S, Zhu Z, Loh L, Tian D, Ren Y, Hu Y, Zhang X, Thomas PG, Inouye M, Doherty PC, Kedzierska K, Xu J.

Nat Commun. 2015 May 13;6:6833. doi: 10.1038/ncomms7833.


Diverse heterologous primary infections radically alter immunodominance hierarchies and clinical outcomes following H7N9 influenza challenge in mice.

Duan S, Meliopoulos VA, McClaren JL, Guo XZ, Sanders CJ, Smallwood HS, Webby RJ, Schultz-Cherry SL, Doherty PC, Thomas PG.

PLoS Pathog. 2015 Feb 10;11(2):e1004642. doi: 10.1371/journal.ppat.1004642. eCollection 2015 Feb.


Fixed expression of single influenza virus-specific TCR chains demonstrates the capacity for TCR α- and β-chain diversity in the face of peptide-MHC class I specificity.

Clemens EB, Doherty PC, La Gruta NL, Turner SJ.

J Immunol. 2015 Feb 1;194(3):898-910. doi: 10.4049/jimmunol.1401792. Epub 2014 Dec 22.


Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

Olson MR, Seah SG, Cullen J, Greyer M, Edenborough K, Doherty PC, Bedoui S, Lew AM, Turner SJ.

J Immunol. 2014 Dec 1;193(11):5420-33. doi: 10.4049/jimmunol.1303359. Epub 2014 Oct 22.


Open letter to the Hon Tony Abbott MP.

McMichael AJ, Leeder SR, Armstrong BK, Basten A, Doherty PC, Douglas RM, Green AC, Nossal GJ, Shearman DJ, Stanley FJ, Vimpani GV, Wodak AD.

Med J Aust. 2014 Sep 1;201(5):252. No abstract available.


CD154+ CD4+ T-cell dependence for effective memory influenza virus-specific CD8+ T-cell responses.

Olson MR, Seah SG, Edenborough K, Doherty PC, Lew AM, Turner SJ.

Immunol Cell Biol. 2014 Aug;92(7):605-11. doi: 10.1038/icb.2014.28. Epub 2014 Apr 29.


The influenza virus-specific CTL immunodominance hierarchy in mice is determined by the relative frequency of high-avidity T cells.

Cukalac T, Chadderton J, Zeng W, Cullen JG, Kan WT, Doherty PC, Jackson DC, Turner SJ, La Gruta NL.

J Immunol. 2014 May 1;192(9):4061-8. doi: 10.4049/jimmunol.1301403. Epub 2014 Apr 2.


Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.

Harland KL, Day EB, Apte SH, Russ BE, Doherty PC, Turner SJ, Kelso A.

Nat Commun. 2014 Mar 28;5:3547. doi: 10.1038/ncomms4547.


Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection.

Cukalac T, Chadderton J, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1485-90. doi: 10.1073/pnas.1323736111. Epub 2014 Jan 13.


Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities.

Quiñones-Parra S, Grant E, Loh L, Nguyen TH, Campbell KA, Tong SY, Miller A, Doherty PC, Vijaykrishna D, Rossjohn J, Gras S, Kedzierska K.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1049-54. doi: 10.1073/pnas.1322229111. Epub 2014 Jan 6.


Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection.

Wang Z, Zhang A, Wan Y, Liu X, Qiu C, Xi X, Ren Y, Wang J, Dong Y, Bao M, Li L, Zhou M, Yuan S, Sun J, Zhu Z, Chen L, Li Q, Zhang Z, Zhang X, Lu S, Doherty PC, Kedzierska K, Xu J.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):769-74. doi: 10.1073/pnas.1321748111. Epub 2013 Dec 23.


Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells.

Rutigliano JA, Sharma S, Morris MY, Oguin TH 3rd, McClaren JL, Doherty PC, Thomas PG.

J Virol. 2014 Feb;88(3):1636-51. doi: 10.1128/JVI.02851-13. Epub 2013 Nov 20.


Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model.

Rosenberger CM, Podyminogin RL, Askovich PS, Navarro G, Kaiser SM, Sanders CJ, McClaren JL, Tam VC, Dash P, Noonan JG, Jones BG, Surman SL, Peschon JJ, Diercks AH, Hurwitz JL, Doherty PC, Thomas PG, Aderem A.

J Gen Virol. 2014 Feb;95(Pt 2):350-62. doi: 10.1099/vir.0.058438-0. Epub 2013 Nov 16.


Acute emergence and reversion of influenza A virus quasispecies within CD8+ T cell antigenic peptides.

Valkenburg SA, Quiñones-Parra S, Gras S, Komadina N, McVernon J, Wang Z, Halim H, Iannello P, Cole C, Laurie K, Kelso A, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K.

Nat Commun. 2013;4:2663. doi: 10.1038/ncomms3663.


The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.

Keating R, Hertz T, Wehenkel M, Harris TL, Edwards BA, McClaren JL, Brown SA, Surman S, Wilson ZS, Bradley P, Hurwitz J, Chi H, Doherty PC, Thomas PG, McGargill MA.

Nat Immunol. 2013 Dec;14(12):1266-76. doi: 10.1038/ni.2741. Epub 2013 Oct 20.


Differential host response, rather than early viral replication efficiency, correlates with pathogenicity caused by influenza viruses.

Askovich PS, Sanders CJ, Rosenberger CM, Diercks AH, Dash P, Navarro G, Vogel P, Doherty PC, Thomas PG, Aderem A.

PLoS One. 2013 Sep 20;8(9):e74863. doi: 10.1371/journal.pone.0074863. eCollection 2013.


Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.

Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD.

Nat Immunol. 2013 May;14(5):480-8. doi: 10.1038/ni.2563. Epub 2013 Mar 24.


Preemptive priming readily overcomes structure-based mechanisms of virus escape.

Valkenburg SA, Gras S, Guillonneau C, Hatton LA, Bird NA, Twist KA, Halim H, Jackson DC, Purcell AW, Turner SJ, Doherty PC, Rossjohn J, Kedzierska K.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5570-5. doi: 10.1073/pnas.1302935110. Epub 2013 Mar 14.


Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels.

Sanders CJ, Vogel P, McClaren JL, Bajracharya R, Doherty PC, Thomas PG.

Am J Physiol Lung Cell Mol Physiol. 2013 Apr 1;304(7):L481-8. doi: 10.1152/ajplung.00343.2012. Epub 2013 Jan 25.

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