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Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease.

Awoniyi DO, Teuchert A, Sutherland JS, Mayanja-Kizza H, Howe R, Mihret A, Loxton AG, Sheehama J, Kassa D, Crampin AC, Dockrell HM, Kidd M, Rosenkrands I, Geluk A, Ottenhoff TH, Corstjens PL, Chegou NN, Walzl G; AE-TBC Consortium.

J Infect. 2016 Jun 14. pii: S0163-4453(16)30124-4. doi: 10.1016/j.jinf.2016.04.036. [Epub ahead of print]


Human biomarkers: can they help us to develop a new tuberculosis vaccine?

Fletcher HA, Dockrell HM.

Future Microbiol. 2016 Jun;11:781-7. doi: 10.2217/fmb.16.15. Epub 2016 May 20.


Host Immune Responses Differ between M. africanum- and M. tuberculosis-Infected Patients following Standard Anti-tuberculosis Treatment.

Tientcheu LD, Haks MC, Agbla SC, Sutherland JS, Adetifa IM, Donkor S, Quinten E, Daramy M, Antonio M, Kampmann B, Ottenhoff TH, Dockrell HM, Ota MO.

PLoS Negl Trop Dis. 2016 May 18;10(5):e0004701. doi: 10.1371/journal.pntd.0004701. eCollection 2016 May.


Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries.

Mbugi EV, Katale BZ, Streicher EM, Keyyu JD, Kendall SL, Dockrell HM, Michel AL, Rweyemamu MM, Warren RM, Matee MI, van Helden PD, Couvin D, Rastogi N.

PLoS One. 2016 May 5;11(5):e0154571. doi: 10.1371/journal.pone.0154571. eCollection 2016.


Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.

Chegou NN, Sutherland JS, Malherbe S, Crampin AC, Corstjens PL, Geluk A, Mayanja-Kizza H, Loxton AG, van der Spuy G, Stanley K, Kotzé LA, van der Vyver M, Rosenkrands I, Kidd M, van Helden PD, Dockrell HM, Ottenhoff TH, Kaufmann SH, Walzl G; AE-TBC consortium.

Thorax. 2016 May 4. pii: thoraxjnl-2015-207999. doi: 10.1136/thoraxjnl-2015-207999. [Epub ahead of print]


A blood RNA signature for tuberculosis disease risk: a prospective cohort study.

Zak DE, Penn-Nicholson A, Scriba TJ, Thompson E, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Hussey GD, Abrahams D, Kafaar F, Hawkridge T, Verver S, Hughes EJ, Ota M, Sutherland J, Howe R, Dockrell HM, Boom WH, Thiel B, Ottenhoff TH, Mayanja-Kizza H, Crampin AC, Downing K, Hatherill M, Valvo J, Shankar S, Parida SK, Kaufmann SH, Walzl G, Aderem A, Hanekom WA; ACS and GC6-74 cohort study groups.

Lancet. 2016 Jun 4;387(10035):2312-22. doi: 10.1016/S0140-6736(15)01316-1. Epub 2016 Mar 24.


Towards new TB vaccines: what are the challenges?

Dockrell HM.

Pathog Dis. 2016 Mar 9. pii: ftw016. [Epub ahead of print]


The Use of Interferon Gamma Inducible Protein 10 as a Potential Biomarker in the Diagnosis of Latent Tuberculosis Infection in Uganda.

Biraro IA, Kimuda S, Egesa M, Cose S, Webb EL, Joloba M, Smith SG, Elliott AM, Dockrell HM, Katamba A.

PLoS One. 2016 Jan 15;11(1):e0146098. doi: 10.1371/journal.pone.0146098. eCollection 2016.


Mycobacterium tuberculosis-specific CD4(+) T-cell response is increased, and Treg cells decreased, in anthelmintic-treated patients with latent TB.

Toulza F, Tsang L, Ottenhoff TH, Brown M, Dockrell HM.

Eur J Immunol. 2016 Mar;46(3):752-61. doi: 10.1002/eji.201545843. Epub 2016 Jan 11.


Isolation and Potential for Transmission of Mycobacterium bovis at Human-livestock-wildlife Interface of the Serengeti Ecosystem, Northern Tanzania.

Katale BZ, Mbugi EV, Siame KK, Keyyu JD, Kendall S, Kazwala RR, Dockrell HM, Fyumagwa RD, Michel AL, Rweyemamu M, Streicher EM, Warren RM, van Helden P, Matee MI.

Transbound Emerg Dis. 2015 Nov 13. doi: 10.1111/tbed.12445. [Epub ahead of print]


Effect of isoniazid preventive therapy on immune responses to mycobacterium tuberculosis: an open label randomised, controlled, exploratory study.

Biraro IA, Egesa M, Kimuda S, Smith SG, Toulza F, Levin J, Joloba M, Katamba A, Cose S, Dockrell HM, Elliott AM.

BMC Infect Dis. 2015 Oct 22;15:438. doi: 10.1186/s12879-015-1201-8.


Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines.

Smith SG, Smits K, Joosten SA, van Meijgaarden KE, Satti I, Fletcher HA, Caccamo N, Dieli F, Mascart F, McShane H, Dockrell HM, Ottenhoff TH; TBVI TB Biomarker Working Group.

PLoS One. 2015 Sep 14;10(9):e0138042. doi: 10.1371/journal.pone.0138042. eCollection 2015.


PD-1, PD-L1 and PD-L2 Gene Expression on T-Cells and Natural Killer Cells Declines in Conjunction with a Reduction in PD-1 Protein during the Intensive Phase of Tuberculosis Treatment.

Hassan SS, Akram M, King EC, Dockrell HM, Cliff JM.

PLoS One. 2015 Sep 11;10(9):e0137646. doi: 10.1371/journal.pone.0137646. eCollection 2015.


Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment.

Cliff JM, Cho JE, Lee JS, Ronacher K, King EC, van Helden P, Walzl G, Dockrell HM.

J Infect Dis. 2016 Feb 1;213(3):485-95. doi: 10.1093/infdis/jiv447. Epub 2015 Sep 7.


Mycobacterial load affects adenosine deaminase 2 levels of tuberculous pleural effusion.

Kim CH, Lee J, Lee J, Cliff JM, Toulza F, Smith S, Yoo SS, Lee SY, Cha SI, Park JY, Dockrell HM.

J Infect. 2015 Oct;71(4):488-91. doi: 10.1016/j.jinf.2015.05.015. Epub 2015 Jun 3. No abstract available.


Differential transcriptomic and metabolic profiles of M. africanum- and M. tuberculosis-infected patients after, but not before, drug treatment.

Tientcheu LD, Maertzdorf J, Weiner J, Adetifa IM, Mollenkopf HJ, Sutherland JS, Donkor S, Kampmann B, Kaufmann SH, Dockrell HM, Ota MO.

Genes Immun. 2015 Jul-Aug;16(5):347-55. doi: 10.1038/gene.2015.21. Epub 2015 Jun 4.


The impact of maternal infection with Mycobacterium tuberculosis on the infant response to bacille Calmette-Guérin immunization.

Mawa PA, Nkurunungi G, Egesa M, Webb EL, Smith SG, Kizindo R, Akello M, Lule SA, Muwanga M, Dockrell HM, Cose S, Elliott AM.

Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). pii: 20140137. doi: 10.1098/rstb.2014.0137.


Investigating the non-specific effects of BCG vaccination on the innate immune system in Ugandan neonates: study protocol for a randomised controlled trial.

Prentice S, Webb EL, Dockrell HM, Kaleebu P, Elliott AM, Cose S.

Trials. 2015 Apr 11;16:149. doi: 10.1186/s13063-015-0682-5.


Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus.

Ronacher K, Joosten SA, van Crevel R, Dockrell HM, Walzl G, Ottenhoff TH.

Immunol Rev. 2015 Mar;264(1):121-37. doi: 10.1111/imr.12257. Review.


Genetic diversity of Mycobacterium tuberculosis isolated from tuberculosis patients in the Serengeti ecosystem in Tanzania.

Mbugi EV, Katale BZ, Siame KK, Keyyu JD, Kendall SL, Dockrell HM, Streicher EM, Michel AL, Rweyemamu MM, Warren RM, Matee MI, van Helden PD.

Tuberculosis (Edinb). 2015 Mar;95(2):170-8. doi: 10.1016/ Epub 2014 Nov 29.

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