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Distinct DNA methylomes of newborns and centenarians.
Heyn H, Li N, Ferreira HJ, Moran S, Pisano DG, Gomez A, Diez J, Sanchez-Mut JV, Setien F, Carmona FJ, Puca AA, Sayols S, Pujana MA, Serra-Musach J, Iglesias-Platas I, Formiga F, Fernandez AF, Fraga MF, Heath SC, Valencia A, Gut IG, Wang J, Esteller M. Heyn H, et al. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10522-7. doi: 10.1073/pnas.1120658109. Epub 2012 Jun 11. Proc Natl Acad Sci U S A. 2012. PMID: 22689993 Free PMC article.
To address this issue, we performed whole-genome bisulfite sequencing (WGBS) of newborn and centenarian genomes. The centenarian DNA had a lower DNA methylation content and a reduced correlation in the methylation status of neighboring cytosine- …
To address this issue, we performed whole-genome bisulfite sequencing (WGBS) of newborn and centenarian genomes. The centen …
Distinct epigenomes in CD4(+) T cells of newborns, middle-ages and centenarians.
Zhao M, Qin J, Yin H, Tan Y, Liao W, Liu Q, Luo S, He M, Liang G, Shi Y, Zhang Q, Cai W, Yin G, Zhou Y, Wang J, Li M, Huang Y, Liu A, Wu H, Zhang Z, Lu Q. Zhao M, et al. Sci Rep. 2016 Dec 5;6:38411. doi: 10.1038/srep38411. Sci Rep. 2016. PMID: 27917918 Free PMC article.
We therefore investigated alterations in the transcriptomes, miRNAomes and DNA methylomes in the same CD4(+)T cells from newborn (NB), middle-aged (MA) and long-lived (LL) individuals to elucidate the molecular changes and their interactions. ...The integrate …
We therefore investigated alterations in the transcriptomes, miRNAomes and DNA methylomes in the same CD4(+)T cells from ne …