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disease specific alterations i frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder
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Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, andmajor depressive disorder
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Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium.
Mol Psychiatry. 2000 Mar;5(2):142-9. doi: 10.1038/sj.mp.4000696.
Mol Psychiatry. 2000.
PMID: 10822341
Severe psychiatric disorders such as schizophrenia, bipolar disorder and major depressive disorder are brain diseases of unknown origin. ...We identified eight protein species that display disease-specific …
Severe psychiatric disorders such as schizophrenia, bipolar disorder and major depressive disorder …
Diagnostic Specificity and Association With Cognition of Molecular Alterations in Prefrontal Somatostatin Neurons in Schizophrenia.
JAMA Psychiatry. 2023 Dec 1;80(12):1235-1245. doi: 10.1001/jamapsychiatry.2023.2972.
JAMA Psychiatry. 2023.
PMID: 37647039
OBJECTIVE: To quantify mRNA levels of SST and related neuropeptides in the DLPFC in individuals with SZ, bipolar disorder (BPD), or major depressive disorder (MDD) and unaffected comparison individuals. ...In SZ, alterations specifical …
OBJECTIVE: To quantify mRNA levels of SST and related neuropeptides in the DLPFC in individuals with SZ, bipolar disorder (BPD …
Chemokine alterations in the postmortem brains of suicide completers.
J Psychiatr Res. 2020 Jan;120:29-33. doi: 10.1016/j.jpsychires.2019.10.008. Epub 2019 Oct 11.
J Psychiatr Res. 2020.
PMID: 31629996
Immunological disturbances have been reported in psychiatric disorders such as major depressive disorder (MDD), bipolar disorder (BP), and schizophrenia. ...We obtained brain tissue samples of the dorsolateral prefrontal cortex …
Immunological disturbances have been reported in psychiatric disorders such as major depressive disorder (MDD), bipo …
Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder.
Transl Psychiatry. 2019 May 23;9(1):151. doi: 10.1038/s41398-019-0492-8.
Transl Psychiatry. 2019.
PMID: 31123247
Free PMC article.
Psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) arise from complex interactions between genetic and environmental factors. ...SCZ subjects showed a substantial burden of differ …
Psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorde …
Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease.
Cell Signal. 2020 Jun;70:109592. doi: 10.1016/j.cellsig.2020.109592. Epub 2020 Feb 29.
Cell Signal. 2020.
PMID: 32119913
Free PMC article.
Many studies implicate altered cyclic nucleotide signaling in the pathophysiology of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ). As such, we explored how phosphodiesterases 2A (PDE2A) and 10A ( …
Many studies implicate altered cyclic nucleotide signaling in the pathophysiology of major depressive disorder ( …
A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia.
Schizophr Res. 2017 Oct;188:132-140. doi: 10.1016/j.schres.2017.01.022. Epub 2017 Jan 17.
Schizophr Res. 2017.
PMID: 28108228
We here evaluated the transcriptional regulation of ECS components in human peripheral blood mononuclear cells (PBMCs) obtained from subjects suffering from bipolar disorder, major depressive disorder and schizophrenia, focusing in partic …
We here evaluated the transcriptional regulation of ECS components in human peripheral blood mononuclear cells (PBMCs) obtained from subject …
Alterations in cell adhesion molecule L1 and functionally related genes in major depression: a postmortem study.
Biol Psychiatry. 2005 Apr 1;57(7):716-25. doi: 10.1016/j.biopsych.2004.12.016.
Biol Psychiatry. 2005.
PMID: 15820228
Presently we hypothesized that CAM-L1, CREB, and laminin may be altered in post mortem brains of depressed subjects. METHODS: Studies were performed in the prefrontal and in the ventral parieto-occipital cortices, of 59 brains from depressed, bipolar, …
Presently we hypothesized that CAM-L1, CREB, and laminin may be altered in post mortem brains of depressed subjects. METHODS: …
Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients.
Schizophr Res. 2008 Mar;100(1-3):270-80. doi: 10.1016/j.schres.2007.12.474. Epub 2008 Feb 19.
Schizophr Res. 2008.
PMID: 18243664
Free PMC article.
Neuregulin-1 (NRG1) and its receptor, ErbB4, have been implicated in schizophrenia at both gene and transcript levels. The present investigation compared NRG1 and ErbB4 protein levels in prefrontal cortical (PFC) cytoplasmic and nuclear fractions among normal, schiz …
Neuregulin-1 (NRG1) and its receptor, ErbB4, have been implicated in schizophrenia at both gene and transcript levels. The present in …
Mitochondrial complex I subunits expression is altered in schizophrenia: a postmortem study.
Biol Psychiatry. 2004 Apr 1;55(7):676-84. doi: 10.1016/j.biopsych.2003.12.012.
Biol Psychiatry. 2004.
PMID: 15038995
METHODS: In this study, three subunits of mitochondrial complex I were analyzed at the level of mRNA and protein in postmortem brain specimens from the prefrontal and the ventral parietooccipital cortex of patients with schizophrenia, major depr …
METHODS: In this study, three subunits of mitochondrial complex I were analyzed at the level of mRNA and protein in postmortem bra …
Elevated GRIA1 mRNA expression in Layer II/III and V pyramidal cells of the DLPFC in schizophrenia.
Schizophr Res. 2007 Dec;97(1-3):277-88. doi: 10.1016/j.schres.2007.09.022. Epub 2007 Oct 17.
Schizophr Res. 2007.
PMID: 17942280
Free PMC article.
Comparisons were made between individuals diagnosed with schizophrenia, bipolar disorder, major depressive disorder and controls (n=15/group). All subunits were expressed at detectable levels in both cell populations for all diseases …
Comparisons were made between individuals diagnosed with schizophrenia, bipolar disorder, major depressive …
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