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Items: 1 to 20 of 87

1.

Histopathological characteristics of renal changes in human renin-angiotensinogen double transgenic rats.

Tochitani T, Mori M, Matsuda K, Kouchi M, Fujii Y, Matsumoto I.

J Toxicol Pathol. 2016 Apr;29(2):125-9. doi: 10.1293/tox.2015-0055. Epub 2015 Dec 12.

2.

EGFR inhibitors Identified as a Potential Treatment for Chordoma in a Focused Compound Screen.

Scheipl S, Barnard M, Cottone L, Jorgensen M, Drewry DH, Zuercher WJ, Turlais F, Ye H, Leite AP, Smith JA, Leithner A, Möller P, Brüderlein S, Guppy N, Amary F, Tirabosco R, Strauss SJ, Pillay N, Flanagan AM.

J Pathol. 2016 Apr 22. doi: 10.1002/path.4729. [Epub ahead of print]

PMID:
27102572
3.

Parental preferences regarding administration of an animal-derived versus a synthetic medication to newborn infants.

Sherman TI, Moya F, Simmons PD, Kurtz D, Shaffer TH.

J Neonatal Perinatal Med. 2016 Mar 17;9(1):7-14. doi: 10.3233/NPM-16915062.

PMID:
27002267
4.

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.

Lochhead PA, Clark J, Wang LZ, Gilmour L, Squires M, Gilley R, Foxton C, Newell DR, Wedge SR, Cook SJ.

Cell Cycle. 2016 Feb 16;15(4):506-18. doi: 10.1080/15384101.2015.1120915.

PMID:
26959608
5.

Therapeutic targeting of casein kinase 1δ in breast cancer.

Rosenberg LH, Lafitte M, Quereda V, Grant W, Chen W, Bibian M, Noguchi Y, Fallahi M, Yang C, Chang JC, Roush WR, Cleveland JL, Duckett DR.

Sci Transl Med. 2015 Dec 16;7(318):318ra202. doi: 10.1126/scitranslmed.aac8773.

PMID:
26676609
6.

Characterization of a nose-only inhaled phosgene acute lung injury mouse model.

Plahovinsak JL, Perry MR, Knostman KA, Segal R, Babin MC.

Inhal Toxicol. 2015;27(14):832-40. doi: 10.3109/08958378.2015.1117549.

7.

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

Hino K, Ikeya M, Horigome K, Matsumoto Y, Ebise H, Nishio M, Sekiguchi K, Shibata M, Nagata S, Matsuda S, Toguchida J.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15438-43. doi: 10.1073/pnas.1510540112. Epub 2015 Nov 30.

8.

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.

Mardilovich K, Baugh M, Crighton D, Kowalczyk D, Gabrielsen M, Munro J, Croft DR, Lourenco F, James D, Kalna G, McGarry L, Rath O, Shanks E, Garnett MJ, McDermott U, Brookfield J, Charles M, Hammonds T, Olson MF.

Oncotarget. 2015 Nov 17;6(36):38469-86. doi: 10.18632/oncotarget.6288.

9.

Identification of an EGFRvIII-JNK2-HGF/c-Met-Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion.

Saunders VC, Lafitte M, Adrados I, Quereda V, Feurstein D, Ling Y, Fallahi M, Rosenberg LH, Duckett DR.

Mol Pharmacol. 2015 Dec;88(6):962-9. doi: 10.1124/mol.115.097774. Epub 2015 Oct 9.

PMID:
26452771
10.

Academic-Pharma drug discovery alliances: seeking ways to eliminate the valley of death.

Hammonds T.

Future Med Chem. 2015;7(14):1891-9. doi: 10.4155/fmc.15.111. Epub 2015 Sep 22.

PMID:
26393391
11.

One-Step Synthesis of 2-Chloropyrimidin-4-ol Derivatives: An Unusual Reactivity of Thiophosgene.

Callingham M, Blum F, Pavé G.

Org Lett. 2015 Oct 2;17(19):4930-2. doi: 10.1021/acs.orglett.5b02375. Epub 2015 Sep 11.

PMID:
26360817
12.

Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties.

Charles MD, Brookfield JL, Ekwuru TC, Stockley M, Dunn J, Riddick M, Hammonds T, Trivier E, Greenland G, Wong AC, Cheasty A, Boyd S, Crighton D, Olson MF.

J Med Chem. 2015 Oct 22;58(20):8309-13. doi: 10.1021/acs.jmedchem.5b01242. Epub 2015 Sep 30.

PMID:
26356364
13.

DSP-1053, a novel serotonin reuptake inhibitor with 5-HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats.

Kato T, Matsumoto Y, Yamamoto M, Matsumoto K, Baba S, Nakamichi K, Matsuda H, Nishimuta H, Yabuuchi K.

Pharmacol Res Perspect. 2015 Jun;3(3):e00142. doi: 10.1002/prp2.142. Epub 2015 May 8.

14.

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.

Sadaie M, Dillon C, Narita M, Young AR, Cairney CJ, Godwin LS, Torrance CJ, Bennett DC, Keith WN, Narita M.

Mol Biol Cell. 2015 Sep 1;26(17):2971-85. doi: 10.1091/mbc.E15-01-0003. Epub 2015 Jul 1. Erratum in: Mol Biol Cell. 2015 Oct 1;26(19):3556. Narita, Masashi [Corrected to Narita, Masako].

15.

Characterisation of liver-specific distribution of a novel 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonist, SKL-13784: comparison with GC-1.

Takahashi N, Izuchi T.

Xenobiotica. 2016;46(2):108-16. doi: 10.3109/00498254.2015.1052862. Epub 2015 Jun 15.

PMID:
26075834
16.

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.

Boyd S, Brookfield JL, Critchlow SE, Cumming IA, Curtis NJ, Debreczeni J, Degorce SL, Donald C, Evans NJ, Groombridge S, Hopcroft P, Jones NP, Kettle JG, Lamont S, Lewis HJ, MacFaull P, McLoughlin SB, Rigoreau LJ, Smith JM, St-Gallay S, Stock JK, Turnbull AP, Wheatley ER, Winter J, Wingfield J.

J Med Chem. 2015 Apr 23;58(8):3611-25. doi: 10.1021/acs.jmedchem.5b00352. Epub 2015 Apr 13.

PMID:
25849762
17.

DSR-98776, a novel selective mGlu5 receptor negative allosteric modulator with potent antidepressant and antimanic activity.

Kato T, Takata M, Kitaichi M, Kassai M, Inoue M, Ishikawa C, Hirose W, Yoshida K, Shimizu I.

Eur J Pharmacol. 2015 Jun 15;757:11-20. doi: 10.1016/j.ejphar.2015.03.024. Epub 2015 Mar 28.

PMID:
25823809
18.

The serotonin 5-HT₁A receptor agonist tandospirone improves executive function in common marmosets.

Baba S, Murai T, Nakako T, Enomoto T, Ono M, Shimizu I, Ikeda K.

Behav Brain Res. 2015;287:120-6. doi: 10.1016/j.bbr.2015.03.025. Epub 2015 Mar 21.

PMID:
25804359
19.

New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva.

Matsumoto Y, Ikeya M, Hino K, Horigome K, Fukuta M, Watanabe M, Nagata S, Yamamoto T, Otsuka T, Toguchida J.

Stem Cells. 2015 Jun;33(6):1730-42. doi: 10.1002/stem.1981.

PMID:
25773749
20.

Addressing the right targets in oncology: challenges and alternative approaches.

Stock JK, Jones NP, Hammonds T, Roffey J, Dillon C.

J Biomol Screen. 2015 Mar;20(3):305-17. doi: 10.1177/1087057114564349. Epub 2015 Jan 22. Review.

PMID:
25614505
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