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Results: 1 to 20 of 66

1.

In vivo evaluation of 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonists: importance of liver selectivity in drug discovery.

Takahashi N, Asano Y, Maeda K, Watanabe N.

Biol Pharm Bull. 2014;37(7):1103-8.

PMID:
24989002
[PubMed - in process]
Free Article
2.

Structural basis for translocation by AddAB helicase-nuclease and its arrest at χ sites.

Krajewski WW, Fu X, Wilkinson M, Cronin NB, Dillingham MS, Wigley DB.

Nature. 2014 Apr 17;508(7496):416-9. doi: 10.1038/nature13037. Epub 2014 Mar 16.

PMID:
24670664
[PubMed - indexed for MEDLINE]
3.

Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP-028--for human safety in clinical study.

Nishizato Y, Imai S, Okahashi N, Yabunaka A, Kunimatsu T, Kikuchi K, Yabuki M.

Toxicol Appl Pharmacol. 2014 May 1;276(3):213-9. doi: 10.1016/j.taap.2014.02.016. Epub 2014 Mar 1.

PMID:
24593921
[PubMed - indexed for MEDLINE]
4.

Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate.

Khanim F, Davies N, Veliça P, Hayden R, Ride J, Pararasa C, Chong MG, Gunther U, Veerapen N, Winn P, Farmer R, Trivier E, Rigoreau L, Drayson M, Bunce C.

Br J Cancer. 2014 Mar 18;110(6):1506-16. doi: 10.1038/bjc.2014.83. Epub 2014 Feb 25.

PMID:
24569460
[PubMed - indexed for MEDLINE]
5.

Pharmacological properties of AC-3933, a novel benzodiazepine receptor partial inverse agonist.

Hashimoto T, Kiyoshi T, Kohayakawa H, Iwamura Y, Yoshida N.

Neuroscience. 2013 Oct 24. pii: S0306-4522(13)00884-1. doi: 10.1016/j.neuroscience.2013.10.031. [Epub ahead of print]

PMID:
24513525
[PubMed - as supplied by publisher]
6.

In vivo pharmacological characterization of AC-3933, a benzodiazepine receptor partial inverse agonist for the treatment of Alzheimer's disease.

Hatayama Y, Hashimoto T, Kohayakawa H, Kiyoshi T, Nakamichi K, Kinoshita T, Yoshida N.

Neuroscience. 2014 Apr 18;265:217-25. doi: 10.1016/j.neuroscience.2014.01.063. Epub 2014 Feb 8.

PMID:
24513386
[PubMed - in process]
7.

Lack of dopamine D4 receptor affinity contributes to the procognitive effect of lurasidone.

Murai T, Nakako T, Ikeda K, Ikejiri M, Ishiyama T, Taiji M.

Behav Brain Res. 2014 Mar 15;261:26-30. doi: 10.1016/j.bbr.2013.11.036. Epub 2013 Dec 1.

PMID:
24304719
[PubMed - in process]
8.

Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonists.

Takahashi N, Maeda K, Asano Y, Watanabe N.

Bioorg Med Chem. 2014 Jan 1;22(1):488-98. doi: 10.1016/j.bmc.2013.11.001. Epub 2013 Nov 13.

PMID:
24290064
[PubMed - in process]
9.

Modulation of inflammatory pain in response to a CCR2/CCR5 antagonist in rodent model.

Okamoto M, Suzuki T, Watanabe N.

J Pharmacol Pharmacother. 2013 Jul;4(3):208-10. doi: 10.4103/0976-500X.114605. No abstract available.

PMID:
23960428
[PubMed]
Free PMC Article
10.

Studying protein-ligand interactions using X-ray crystallography.

Turnbull AP, Emsley P.

Methods Mol Biol. 2013;1008:457-77. doi: 10.1007/978-1-62703-398-5_17.

PMID:
23729263
[PubMed - indexed for MEDLINE]
11.

A pharmacoeconomic analysis of in-hospital costs resulting from reintubation in preterm infants treated with lucinactant, beractant, or poractant alfa.

Guardia CG, Moya FR, Sinha S, Simmons PD, Segal R, Greenspan JS.

J Pediatr Pharmacol Ther. 2012 Jul;17(3):220-7. doi: 10.5863/1551-6776-17.3.220.

PMID:
23258964
[PubMed]
Free PMC Article
12.

Synthesis and pharmacological profile of a new selective G protein-coupled receptor 119 agonist; 6-((2-fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one.

Sakairi M, Kogami M, Torii M, Makino M, Kataoka D, Okamoto R, Miyazawa T, Inoue M, Takahashi N, Harada S, Watanabe N.

Chem Pharm Bull (Tokyo). 2012;60(9):1093-5.

PMID:
22976315
[PubMed - indexed for MEDLINE]
Free Article
13.

Synthesis and biological evaluation of a 6-aminofuro[3,2-c]pyridin-3(2H)-one series of GPR 119 agonists.

Sakairi M, Kogami M, Torii M, Kuno Y, Ohsawa Y, Makino M, Kataoka D, Okamoto R, Miyazawa T, Inoue M, Takahashi N, Harada S, Watanabe N.

Arzneimittelforschung. 2012 Nov;62(11):537-44. doi: 10.1055/s-0032-1323760. Epub 2012 Sep 12.

PMID:
22972470
[PubMed - indexed for MEDLINE]
14.

Synthesis and SAR studies of bicyclic amine series GPR119 agonists.

Sakairi M, Kogami M, Torii M, Kataoka H, Fujieda H, Makino M, Kataoka D, Okamoto R, Miyazawa T, Okabe M, Inoue M, Takahashi N, Harada S, Watanabe N.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5123-8. doi: 10.1016/j.bmcl.2012.05.117. Epub 2012 Jun 17.

PMID:
22765901
[PubMed - indexed for MEDLINE]
15.

Biological and functional characteristics of a novel low-molecular weight antagonist of glucose-dependent insulinotropic polypeptide receptor, SKL-14959, in vitro and in vivo.

Nakamura T, Tanimoto H, Mizuno Y, Tsubamoto Y, Noda H.

Diabetes Obes Metab. 2012 Jun;14(6):511-7. doi: 10.1111/j.1463-1326.2011.01555.x. Epub 2012 Jan 18.

PMID:
22192426
[PubMed - indexed for MEDLINE]
16.

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.

Heikkila T, Wheatley E, Crighton D, Schroder E, Boakes A, Kaye SJ, Mezna M, Pang L, Rushbrooke M, Turnbull A, Olson MF.

PLoS One. 2011;6(9):e24825. doi: 10.1371/journal.pone.0024825. Epub 2011 Sep 20.

PMID:
21949762
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Targeting cancer using fragment based drug discovery.

Turnbull AP, Boyd SM.

Anticancer Agents Med Chem. 2012 Jan;12(1):40-8.

PMID:
21707503
[PubMed - indexed for MEDLINE]
18.

Practical preparation of ethyl 2-methylthiophene-3-carboxylate.

Kogami M, Watanabe N.

Chem Pharm Bull (Tokyo). 2011;59(6):797-8.

PMID:
21628923
[PubMed - indexed for MEDLINE]
Free Article
19.

Evaluation of the searching abilities of HBOP and HBSITE for binding pocket detection.

Oda A, Yamaotsu N, Hirono S.

J Comput Chem. 2009 Dec;30(16):2728-37. doi: 10.1002/jcc.21299.

PMID:
19399761
[PubMed - indexed for MEDLINE]
20.

Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.

Hagio T, Kishikawa K, Kawabata K, Tasaka S, Hashimoto S, Hasegawa N, Ishizaka A.

Pulm Pharmacol Ther. 2008 Dec;21(6):884-91. doi: 10.1016/j.pupt.2008.10.002. Epub 2008 Oct 17.

PMID:
18992355
[PubMed - indexed for MEDLINE]

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