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Year Number of Results
1982 3
1983 1
1984 6
1985 3
1986 1
1987 4
1988 4
1989 4
1990 4
1991 2
1992 3
1994 1
1996 1
2002 1
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2005 1
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2010 2
2024 0

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44 results

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Page 1
Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues.
Banerjee A, Schepmann D, Wünsch B. Banerjee A, et al. Bioorg Med Chem. 2010 Jun 1;18(11):4095-102. doi: 10.1016/j.bmc.2010.04.002. Epub 2010 Apr 4. Bioorg Med Chem. 2010. PMID: 20451396
A series of dioxadrol analogues with fluorine substituents in position 4 of the piperidine ring has been synthesized and pharmacologically evaluated. ...The NMDA receptor affinity of 8c (WMS-2513) with an additional fluorine atom in equatorial 4-position was slightly reduc …
A series of dioxadrol analogues with fluorine substituents in position 4 of the piperidine ring has been synthesized and pharmacologi …
Enantiomeric and diastereomeric dioxadrols: behavioral, biochemical and chemical determination of the configuration necessary for phencyclidine-like properties.
Jacobson AE, Harrison EA Jr, Mattson MV, Rafferty MF, Rice KC, Woods JH, Winger G, Solomon RE, Lessor RA, Silverton JV. Jacobson AE, et al. J Pharmacol Exp Ther. 1987 Oct;243(1):110-7. J Pharmacol Exp Ther. 1987. PMID: 2822892
Dioxadrol exists in four isomeric forms. alpha-(+)-Dioxadrol (dexoxadrol) showed phencyclidine (PCP)-like activity in rhesus monkeys trained to discriminate s.c. administration of ketamine, but neither alpha-(-)-dioxadrol (levoxadrol) nor beta-(+/-)-dioxad …
Dioxadrol exists in four isomeric forms. alpha-(+)-Dioxadrol (dexoxadrol) showed phencyclidine (PCP)-like activity in rhesus m …
Phencyclidine-like discriminative stimulus properties of the stereoisomers of dioxadrol.
Slifer BL, Balster RL. Slifer BL, et al. Subst Alcohol Actions Misuse. 1984-1985;5(6):273-80. Subst Alcohol Actions Misuse. 1984. PMID: 6545061
Generalization tests were conducted with other doses of PCP as well as with various doses of the stereoisomers of dioxadrol. Dose-dependent PCP-like discriminative stimulus effects were obtained with dexoxadrol but not with levoxadrol, however overall rates of responding w …
Generalization tests were conducted with other doses of PCP as well as with various doses of the stereoisomers of dioxadrol. Dose-dep …
The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord.
Berry SC, Anis NA, Lodge D. Berry SC, et al. Brain Res. 1984 Jul 30;307(1-2):85-90. doi: 10.1016/0006-8993(84)90463-3. Brain Res. 1984. PMID: 6147179
The effects of the dissociative anaesthetic, etoxadrol, and the stereoisomers of dioxadrol, dexoxadrol and levoxadrol, were examined on the excitation of spinal neurones by electrophoretically administered amino acids in pentobarbitone- or urethane-anaesthetized rats, or p …
The effects of the dissociative anaesthetic, etoxadrol, and the stereoisomers of dioxadrol, dexoxadrol and levoxadrol, were examined …
Phencyclidine-induced catalepsy in pigeons: specificity and stereoselectivity.
Koek W, Woods JH, Rice KC, Jacobson AE, Huguenin PN, Burke TR Jr. Koek W, et al. Eur J Pharmacol. 1984 Nov 27;106(3):635-8. doi: 10.1016/0014-2999(84)90070-0. Eur J Pharmacol. 1984. PMID: 6542865 Free article.
Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and alpha-dioxadrol. The procedure is suitable for studying compounds which may interact with phencyclidine receptors....
Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and alpha-dioxadrol. The pr …
Phencyclidine receptors in rat brain cortex.
Mendelsohn LG, Kerchner GA, Kalra V, Zimmerman DM, Leander JD. Mendelsohn LG, et al. Biochem Pharmacol. 1984 Nov 15;33(22):3529-35. doi: 10.1016/0006-2952(84)90133-3. Biochem Pharmacol. 1984. PMID: 6095851
Stereoselective displacement of PCP at the high affinity receptor was observed with the isomers of cyclazocine, cyclorphan, SKF-10,047 and dioxadrol (dexoxadrol and levoxadrol). Naloxone, 4,5,6,7-tetrahydroisoxazolo(S,4-C)pyridin-3-ol (THIP) hydrate and haloperidol inhibit …
Stereoselective displacement of PCP at the high affinity receptor was observed with the isomers of cyclazocine, cyclorphan, SKF-10,047 and …
Neuroendocrine responses produced by enantiomeric pairs of drugs that interact with phencyclidine and sigma receptors.
Pechnick RN, Poland RE. Pechnick RN, et al. Eur J Pharmacol. 1994 Sep 22;263(1-2):115-20. doi: 10.1016/0014-2999(94)90531-2. Eur J Pharmacol. 1994. PMID: 7821343
Rats were injected with the enantiomers of 1-(1-phenylcyclohexyl)-3-methylpiperidine (PCMP), N-allylnormetazocine (SKF 10,047), dioxadrol (dexoxadrol and levoxadrol) or pentazocine, and plasma levels of adrenocorticotropin (ACTH) and corticosterone were determined by radio …
Rats were injected with the enantiomers of 1-(1-phenylcyclohexyl)-3-methylpiperidine (PCMP), N-allylnormetazocine (SKF 10,047), dioxadrol …
44 results