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Results: 1 to 20 of 191

1.

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.

Fontaine SN, Martin MD, Akoury E, Assimon VA, Borysov S, Nordhues BA, Sabbagh JJ, Cockman M, Gestwicki JE, Zweckstetter M, Dickey CA.

Hum Mol Genet. 2015 Apr 16. pii: ddv135. [Epub ahead of print]

PMID:
25882706
2.

Isoform Selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.

Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM Jr, Zuiderweg ER, Gestwicki JE, Dickey CA.

J Biol Chem. 2015 Apr 11. pii: jbc.M115.637595. [Epub ahead of print]

3.

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy.

Blair LJ, Frauen HD, Zhang B, Nordhues BA, Bijan S, Lin YC, Zamudio F, Hernandez LD, Sabbagh JJ, Selenica ML, Dickey CA.

Acta Neuropathol Commun. 2015 Jan 31;3:8. doi: 10.1186/s40478-015-0186-2.

4.

Cellular factors modulating the mechanism of tau protein aggregation.

Fontaine SN, Sabbagh JJ, Baker J, Martinez-Licha CR, Darling A, Dickey CA.

Cell Mol Life Sci. 2015 Feb 11. [Epub ahead of print]

PMID:
25666877
5.

The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease.

Blair LJ, Baker JD, Sabbagh JJ, Dickey CA.

J Neurochem. 2015 Apr;133(1):1-13. doi: 10.1111/jnc.13033. Epub 2015 Feb 24.

PMID:
25628064
6.

Synthesis, Stereochemical Analysis, and Derivatization of Myricanol Provide New Probes That Promote Autophagic Tau Clearance.

Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki JE, Smith GR, Reitz AB, Baker BJ, Dickey CA.

ACS Chem Biol. 2015 Jan 30. [Epub ahead of print]

PMID:
25588114
7.

Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.

Sabbagh JJ, O'Leary JC 3rd, Blair LJ, Klengel T, Nordhues BA, Fontaine SN, Binder EB, Dickey CA.

PLoS One. 2014 Sep 5;9(9):e107241. doi: 10.1371/journal.pone.0107241. eCollection 2014.

8.

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.

Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA.

J Neuroinflammation. 2014 Sep 3;11:152. doi: 10.1186/s12974-014-0152-0.

9.

Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease.

Blair LJ, Sabbagh JJ, Dickey CA.

Expert Opin Ther Targets. 2014 Oct;18(10):1219-32. doi: 10.1517/14728222.2014.943185. Epub 2014 Jul 29. Review.

PMID:
25069659
10.

Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.

Stothert AR, Suntharalingam A, Huard DJ, Fontaine SN, Crowley VM, Mishra S, Blagg BS, Lieberman RL, Dickey CA.

Hum Mol Genet. 2014 Dec 15;23(24):6470-80. doi: 10.1093/hmg/ddu367. Epub 2014 Jul 15.

PMID:
25027323
11.

Decreasing bullying behaviors in middle school: expect respect.

Nese RN, Horner RH, Dickey CR, Stiller B, Tomlanovich A.

Sch Psychol Q. 2014 Sep;29(3):272-86. doi: 10.1037/spq0000070. Epub 2014 May 12.

PMID:
24820010
12.

Creating Opportunities for Organizational Leadership (COOL): Creating a culture and curriculum that fosters psychiatric leadership development and quality improvement.

Dickey C, Dismukes R, Topor D.

Acad Psychiatry. 2014 Jun;38(3):383-7. doi: 10.1007/s40596-014-0082-2. Epub 2014 Mar 25.

PMID:
24664604
13.

Neuropsychiatry and neuroscience education of psychiatry trainees: attitudes and barriers.

Benjamin S, Travis MJ, Cooper JJ, Dickey CC, Reardon CL.

Acad Psychiatry. 2014 Apr;38(2):135-40. doi: 10.1007/s40596-014-0051-9. Epub 2014 Mar 19.

PMID:
24643397
14.

Hsp90-Tau complex reveals molecular basis for specificity in chaperone action.

Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SG.

Cell. 2014 Feb 27;156(5):963-74. doi: 10.1016/j.cell.2014.01.037.

15.

Decreasing inter-resident conflict by using computer-generated on-call schedules.

Dickey CC, Tarnavsky T, Khan I, Panych LP.

Acad Psychiatry. 2014 Apr;38(2):213-6. doi: 10.1007/s40596-014-0060-8. Epub 2014 Feb 12.

PMID:
24519802
16.

Ligands for glaucoma-associated myocilin discovered by a generic binding assay.

Orwig SD, Chi PV, Du Y, Hill SE, Cavitt MA, Suntharalingam A, Turnage KC, Dickey CA, France S, Fu H, Lieberman RL.

ACS Chem Biol. 2014 Feb 21;9(2):517-25. doi: 10.1021/cb4007776. Epub 2013 Dec 9.

17.

Resident/faculty collaboration for systems-based quality improvement.

Benzer JK, Bauer MS, Charns MP, Topor DR, Dickey CC.

Acad Psychiatry. 2013 Nov;37(6):433-5. doi: 10.1176/appi.ap.12090169. No abstract available.

PMID:
24185294
18.

Working memory in schizotypal personality disorder: fMRI activation and deactivation differences.

Vu MA, Thermenos HW, Terry DP, Wolfe DJ, Voglmaier MM, Niznikiewicz MA, McCarley RW, Seidman LJ, Dickey CC.

Schizophr Res. 2013 Dec;151(1-3):113-23. doi: 10.1016/j.schres.2013.09.013. Epub 2013 Oct 23.

PMID:
24161536
19.

Potential synergy between tau aggregation inhibitors and tau chaperone modulators.

Blair LJ, Zhang B, Dickey CA.

Alzheimers Res Ther. 2013 Sep 16;5(5):41. doi: 10.1186/alzrt207. eCollection 2013. Review.

20.

The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance.

O'Leary JC 3rd, Zhang B, Koren J 3rd, Blair L, Dickey CA.

CNS Neurol Disord Drug Targets. 2013 Dec;12(8):1157-62. Review.

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